Sedating effects of Humulus lupulus L. extracts
It was the aim of the study to check ethanolic and CO 2 extracts from Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications o...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2006-09, Vol.13 (8), p.535-541 |
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| creator | Schiller, H. Forster, A. Vonhoff, C. Hegger, M. Biller, A. Winterhoff, H. |
| description | It was the aim of the study to check ethanolic and CO
2 extracts from
Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations.
This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the
α-bitter acids proved to the be most active constituents, the
β-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic
Humulus extracts. |
| doi_str_mv | 10.1016/j.phymed.2006.05.010 |
| format | Article |
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2 extracts from
Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations.
This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the
α-bitter acids proved to the be most active constituents, the
β-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic
Humulus extracts.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2006.05.010</identifier><identifier>PMID: 16860977</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; Anti-Anxiety Agents - analysis ; Body Temperature - drug effects ; Dosage and administration ; Drug therapy ; Female ; Hop oil ; Hops ; Humulus - chemistry ; Humulus lupulus L ; Hypnotics and Sedatives - pharmacology ; Mice ; Motor Activity - drug effects ; Muscle relaxation ; Plant Extracts - pharmacology ; Sedation ; Sleep - drug effects ; α-bitter acids ; β-bitter acids</subject><ispartof>Phytomedicine (Stuttgart), 2006-09, Vol.13 (8), p.535-541</ispartof><rights>2006 Elsevier GmbH</rights><rights>COPYRIGHT 2006 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-60d628a48b225f2e6bc25be81fa4711d6e5ed03d0508f421c1427833c3ba3de3</citedby><cites>FETCH-LOGICAL-c531t-60d628a48b225f2e6bc25be81fa4711d6e5ed03d0508f421c1427833c3ba3de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711306001000$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16860977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiller, H.</creatorcontrib><creatorcontrib>Forster, A.</creatorcontrib><creatorcontrib>Vonhoff, C.</creatorcontrib><creatorcontrib>Hegger, M.</creatorcontrib><creatorcontrib>Biller, A.</creatorcontrib><creatorcontrib>Winterhoff, H.</creatorcontrib><title>Sedating effects of Humulus lupulus L. extracts</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>It was the aim of the study to check ethanolic and CO
2 extracts from
Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations.
This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the
α-bitter acids proved to the be most active constituents, the
β-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic
Humulus extracts.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - analysis</subject><subject>Body Temperature - drug effects</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Hop oil</subject><subject>Hops</subject><subject>Humulus - chemistry</subject><subject>Humulus lupulus L</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Muscle relaxation</subject><subject>Plant Extracts - pharmacology</subject><subject>Sedation</subject><subject>Sleep - drug effects</subject><subject>α-bitter acids</subject><subject>β-bitter acids</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoNY7Fr9ByIDgnczPfmc2RuhFLXCQi_aC-9CJjlZs8zHmsyI_fdmnEUQlpKLQM7zJufkIeQdhYoCVdeH6vjjqUdXMQBVgayAwguyoYo2JWzl95dkA1shyppSfklep3QAoGJbwytySVWjYFvXG3L9gM5MYdgX6D3aKRWjL-7mfu7mVHTz8e--qwr8PUWTy2_IhTddwren_Yo8fvn8eHtX7u6_fru92ZVWcjqVCpxijRFNy5j0DFVrmWyxod6I3JBTKNEBdyCh8YJRSwWrG84tbw13yK_Ix_XaYxx_zpgm3YdksevMgOOctGpqlWeRGfywgnvToQ6DH5c-F1jfUMkFsFrVmSrPUHscMJpuHNCHfPwfX53h83LYB3s2INaAjWNKEb0-xtCb-KQp6EWXPuhVl150aZA668qx96cx53ap_Qud_GTg0wpg_utfAaNONuBg0YWYbWk3hudf-AP0K6TN</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Schiller, H.</creator><creator>Forster, A.</creator><creator>Vonhoff, C.</creator><creator>Hegger, M.</creator><creator>Biller, A.</creator><creator>Winterhoff, H.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Sedating effects of Humulus lupulus L. extracts</title><author>Schiller, H. ; Forster, A. ; Vonhoff, C. ; Hegger, M. ; Biller, A. ; Winterhoff, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-60d628a48b225f2e6bc25be81fa4711d6e5ed03d0508f421c1427833c3ba3de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - analysis</topic><topic>Body Temperature - drug effects</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Hop oil</topic><topic>Hops</topic><topic>Humulus - chemistry</topic><topic>Humulus lupulus L</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Muscle relaxation</topic><topic>Plant Extracts - pharmacology</topic><topic>Sedation</topic><topic>Sleep - drug effects</topic><topic>α-bitter acids</topic><topic>β-bitter acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiller, H.</creatorcontrib><creatorcontrib>Forster, A.</creatorcontrib><creatorcontrib>Vonhoff, C.</creatorcontrib><creatorcontrib>Hegger, M.</creatorcontrib><creatorcontrib>Biller, A.</creatorcontrib><creatorcontrib>Winterhoff, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiller, H.</au><au>Forster, A.</au><au>Vonhoff, C.</au><au>Hegger, M.</au><au>Biller, A.</au><au>Winterhoff, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sedating effects of Humulus lupulus L. extracts</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>13</volume><issue>8</issue><spage>535</spage><epage>541</epage><pages>535-541</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>It was the aim of the study to check ethanolic and CO
2 extracts from
Humulus lupulus for sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the ketamine-induced sleeping time and reduced body temperature, confirming a central sedating effect. No indications of anxiolytic activity were found in the elevated plus maze test for any of the test preparations.
This sedating activity could be attributed to three categories of constituents of lipophilic hops extracts. Though the
α-bitter acids proved to the be most active constituents, the
β-bitter acids and the hop oil clearly contributed to the sedating activity of lipophilic
Humulus extracts.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>16860977</pmid><doi>10.1016/j.phymed.2006.05.010</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2006-09, Vol.13 (8), p.535-541 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Anti-Anxiety Agents - analysis Body Temperature - drug effects Dosage and administration Drug therapy Female Hop oil Hops Humulus - chemistry Humulus lupulus L Hypnotics and Sedatives - pharmacology Mice Motor Activity - drug effects Muscle relaxation Plant Extracts - pharmacology Sedation Sleep - drug effects α-bitter acids β-bitter acids |
| title | Sedating effects of Humulus lupulus L. extracts |
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