T cells targeted against a single minor histocompatibility antigen can cure solid tumors
T cells responsive to minor histocompatibility (H) antigens are extremely effective in curing leukemia but it remains unknown whether they can eradicate solid tumors. We report that injection of CD8 + T cells primed against the immunodominant H7 a minor H antigen can cure established melanomas in mi...
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| Veröffentlicht in: | Nature medicine 2005-11, Vol.11 (11), p.1222-1229 |
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| creator | Perreault, Claude Meunier, Marie-Christine Delisle, Jean-Sébastien Bergeron, Julie Rineau, Vincent Baron, Chantal |
| description | T cells responsive to minor histocompatibility (H) antigens are extremely effective in curing leukemia but it remains unknown whether they can eradicate solid tumors. We report that injection of CD8
+
T cells primed against the immunodominant H7
a
minor H antigen can cure established melanomas in mice. Tumor rejection was initiated by preferential extravasation at the tumor site of interferon (IFN)-γ–producing H7
a
-specific T cells. Intratumoral release of IFN-γ had two crucial effects: inhibition of tumor angiogenesis and upregulation of major histocompatibility complex (MHC) class I expression on tumor cells. Despite ubiquitous expression of H7
a
, dissemination of a few H7
a
-specific T cells in extralymphoid organs caused neither graft-versus-host disease (GVHD) nor vitiligo because host nonhematopoietic cells were protected by their low expression of MHC class I. Our preclinical model yields unique insights into how minor H antigen–based immunotherapy could be used to treat human solid tumors. |
| doi_str_mv | 10.1038/nm1311 |
| format | Article |
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+
T cells primed against the immunodominant H7
a
minor H antigen can cure established melanomas in mice. Tumor rejection was initiated by preferential extravasation at the tumor site of interferon (IFN)-γ–producing H7
a
-specific T cells. Intratumoral release of IFN-γ had two crucial effects: inhibition of tumor angiogenesis and upregulation of major histocompatibility complex (MHC) class I expression on tumor cells. Despite ubiquitous expression of H7
a
, dissemination of a few H7
a
-specific T cells in extralymphoid organs caused neither graft-versus-host disease (GVHD) nor vitiligo because host nonhematopoietic cells were protected by their low expression of MHC class I. Our preclinical model yields unique insights into how minor H antigen–based immunotherapy could be used to treat human solid tumors.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm1311</identifier><identifier>PMID: 16227989</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Curing ; Cytotoxicity, Immunologic - genetics ; Female ; Flow Cytometry ; Immunohistochemistry ; Immunotherapy ; Infectious Diseases ; Injection ; Interferon-gamma - biosynthesis ; Leukemia ; Metabolic Diseases ; Mice ; Mice, Congenic ; Minor Histocompatibility Antigens - immunology ; Molecular Medicine ; Neoplasm Transplantation ; Neoplasms - immunology ; Neoplasms - therapy ; Neoplasms, Experimental - therapy ; Neurosciences ; Skin diseases ; T-Lymphocytes - immunology ; Transplantation, Homologous ; Tumors</subject><ispartof>Nature medicine, 2005-11, Vol.11 (11), p.1222-1229</ispartof><rights>Springer Nature America, Inc. 2005</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-e7993dbf2336a040f2fe1d92cda7a76b74a4381d45f00b53d59268f15fd936693</citedby><cites>FETCH-LOGICAL-c564t-e7993dbf2336a040f2fe1d92cda7a76b74a4381d45f00b53d59268f15fd936693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm1311$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm1311$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2727,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16227989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perreault, Claude</creatorcontrib><creatorcontrib>Meunier, Marie-Christine</creatorcontrib><creatorcontrib>Delisle, Jean-Sébastien</creatorcontrib><creatorcontrib>Bergeron, Julie</creatorcontrib><creatorcontrib>Rineau, Vincent</creatorcontrib><creatorcontrib>Baron, Chantal</creatorcontrib><title>T cells targeted against a single minor histocompatibility antigen can cure solid tumors</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>T cells responsive to minor histocompatibility (H) antigens are extremely effective in curing leukemia but it remains unknown whether they can eradicate solid tumors. We report that injection of CD8
+
T cells primed against the immunodominant H7
a
minor H antigen can cure established melanomas in mice. Tumor rejection was initiated by preferential extravasation at the tumor site of interferon (IFN)-γ–producing H7
a
-specific T cells. Intratumoral release of IFN-γ had two crucial effects: inhibition of tumor angiogenesis and upregulation of major histocompatibility complex (MHC) class I expression on tumor cells. Despite ubiquitous expression of H7
a
, dissemination of a few H7
a
-specific T cells in extralymphoid organs caused neither graft-versus-host disease (GVHD) nor vitiligo because host nonhematopoietic cells were protected by their low expression of MHC class I. Our preclinical model yields unique insights into how minor H antigen–based immunotherapy could be used to treat human solid tumors.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Curing</subject><subject>Cytotoxicity, Immunologic - genetics</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Infectious Diseases</subject><subject>Injection</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Leukemia</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Congenic</subject><subject>Minor Histocompatibility Antigens - immunology</subject><subject>Molecular Medicine</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Neurosciences</subject><subject>Skin diseases</subject><subject>T-Lymphocytes - 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genetics</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Immunohistochemistry</topic><topic>Immunotherapy</topic><topic>Infectious Diseases</topic><topic>Injection</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Leukemia</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Congenic</topic><topic>Minor Histocompatibility Antigens - immunology</topic><topic>Molecular Medicine</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Neoplasms, Experimental - therapy</topic><topic>Neurosciences</topic><topic>Skin diseases</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplantation, Homologous</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perreault, Claude</creatorcontrib><creatorcontrib>Meunier, Marie-Christine</creatorcontrib><creatorcontrib>Delisle, Jean-Sébastien</creatorcontrib><creatorcontrib>Bergeron, Julie</creatorcontrib><creatorcontrib>Rineau, Vincent</creatorcontrib><creatorcontrib>Baron, Chantal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perreault, Claude</au><au>Meunier, Marie-Christine</au><au>Delisle, Jean-Sébastien</au><au>Bergeron, Julie</au><au>Rineau, Vincent</au><au>Baron, Chantal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T cells targeted against a single minor histocompatibility antigen can cure solid tumors</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>11</volume><issue>11</issue><spage>1222</spage><epage>1229</epage><pages>1222-1229</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>T cells responsive to minor histocompatibility (H) antigens are extremely effective in curing leukemia but it remains unknown whether they can eradicate solid tumors. We report that injection of CD8
+
T cells primed against the immunodominant H7
a
minor H antigen can cure established melanomas in mice. Tumor rejection was initiated by preferential extravasation at the tumor site of interferon (IFN)-γ–producing H7
a
-specific T cells. Intratumoral release of IFN-γ had two crucial effects: inhibition of tumor angiogenesis and upregulation of major histocompatibility complex (MHC) class I expression on tumor cells. Despite ubiquitous expression of H7
a
, dissemination of a few H7
a
-specific T cells in extralymphoid organs caused neither graft-versus-host disease (GVHD) nor vitiligo because host nonhematopoietic cells were protected by their low expression of MHC class I. Our preclinical model yields unique insights into how minor H antigen–based immunotherapy could be used to treat human solid tumors.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16227989</pmid><doi>10.1038/nm1311</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2005-11, Vol.11 (11), p.1222-1229 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68764692 |
| source | MEDLINE; Nature; SpringerNature Journals |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer Research Curing Cytotoxicity, Immunologic - genetics Female Flow Cytometry Immunohistochemistry Immunotherapy Infectious Diseases Injection Interferon-gamma - biosynthesis Leukemia Metabolic Diseases Mice Mice, Congenic Minor Histocompatibility Antigens - immunology Molecular Medicine Neoplasm Transplantation Neoplasms - immunology Neoplasms - therapy Neoplasms, Experimental - therapy Neurosciences Skin diseases T-Lymphocytes - immunology Transplantation, Homologous Tumors |
| title | T cells targeted against a single minor histocompatibility antigen can cure solid tumors |
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