Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells

Ag presentation by dendritic cells (DC) is essential to effective antitumor T cell responses in cancer patients. Depending on their origin, maturation state, and the ambient cytokine milieu, DC can differentiate into distinct subpopulations, which preferentially either induce Th1 cell activation (CD...

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Veröffentlicht in:	Journal of Immunology 2006-09, Vol.177 (5), p.3448-3460
Hauptverfasser:	Bellone, Graziella, Carbone, Anna, Smirne, Carlo, Scirelli, Tiziana, Buffolino, Alessandra, Novarino, Anna, Stacchini, Alessandra, Bertetto, Oscar, Palestro, Giorgio, Sorio, Claudio, Scarpa, Aldo, Emanuelli, Giorgio, Rodeck, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Cell Differentiation Cell Line, Tumor Culture Media Cytokines - genetics Cytokines - metabolism Dendritic Cells - cytology Dendritic Cells - immunology Female Gene Expression Humans Immune Tolerance - immunology Male Mice Middle Aged Monocytes - cytology Monocytes - metabolism Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Phenotype RNA, Messenger - genetics Xenograft Model Antitumor Assays
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