Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic dilated cardiomyopathy
Nonischemic dilated cardiomyopathy (NIDCM) is associated with left ventricular remodeling, hypertrophy, and mitochondrial metabolic abnormalities in vitro. We evaluated the hypothesis that energy supply, as judged by the rate of myocardial oxidative metabolism, is inadequate to meet oxygen demand in...
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| Veröffentlicht in: | Journal of nuclear cardiology 2006-07, Vol.13 (4), p.544-553 |
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| creator | Kronenberg, Marvin W. Cohen, Gerald I. Leonen, Marlo F. Mladsi, Thomas A. Di Carli, Marcelo F. |
| description | Nonischemic dilated cardiomyopathy (NIDCM) is associated with left ventricular remodeling, hypertrophy, and mitochondrial metabolic abnormalities in vitro. We evaluated the hypothesis that energy supply, as judged by the rate of myocardial oxidative metabolism, is inadequate to meet oxygen demand in patients with NIDCM compared with normal subjects.
We used positron emission tomography to determine the myocardial carbon 11 acetate decay rate (k
mono) as an index of energy supply, and we compared k
mono with the rate-pressure product (RPP) as an index of metabolic demand in 7 patients with NIDCM and 7 normal subjects. The mean k
mono value (SEM) was 0.060 ± 0.006 min
−1 in NIDCM patients versus 0.054 ± 0.002 in normal subjects (
P = not significant). The RPP was 9949 ± 931 beats/min
·
mm Hg in NIDCM patients and 6521 ± 476 in normal subjects (
P = .007). The relationship of k
mono to this index of demand (k
mono/RPP) was 6.2 × 10
−6 in NIDCM patients but was 8.5 × 10
−6 in normal subjects (
P = .003). Thus RPP, as an index of myocardial oxygen demand, was poorly matched by the rate of oxidative metabolism in those patients with NIDCM. The k
mono was closely related to RPP in normal subjects (
r = 0.83,
P = .02) but not in NIDCM patients. Furthermore, there was no significant relationship between k
mono and wall stress as another index of oxygen demand.
These results are consistent with a mitochondrial metabolic abnormality in heart failure. This metabolic mismatch detected by positron emission tomography may contribute to the pathophysiology of congestive heart failure and left ventricular remodeling. |
| doi_str_mv | 10.1016/j.nuclcard.2006.04.002 |
| format | Article |
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We used positron emission tomography to determine the myocardial carbon 11 acetate decay rate (k
mono) as an index of energy supply, and we compared k
mono with the rate-pressure product (RPP) as an index of metabolic demand in 7 patients with NIDCM and 7 normal subjects. The mean k
mono value (SEM) was 0.060 ± 0.006 min
−1 in NIDCM patients versus 0.054 ± 0.002 in normal subjects (
P = not significant). The RPP was 9949 ± 931 beats/min
·
mm Hg in NIDCM patients and 6521 ± 476 in normal subjects (
P = .007). The relationship of k
mono to this index of demand (k
mono/RPP) was 6.2 × 10
−6 in NIDCM patients but was 8.5 × 10
−6 in normal subjects (
P = .003). Thus RPP, as an index of myocardial oxygen demand, was poorly matched by the rate of oxidative metabolism in those patients with NIDCM. The k
mono was closely related to RPP in normal subjects (
r = 0.83,
P = .02) but not in NIDCM patients. Furthermore, there was no significant relationship between k
mono and wall stress as another index of oxygen demand.
These results are consistent with a mitochondrial metabolic abnormality in heart failure. This metabolic mismatch detected by positron emission tomography may contribute to the pathophysiology of congestive heart failure and left ventricular remodeling.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1016/j.nuclcard.2006.04.002</identifier><identifier>PMID: 16919578</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Cardiomyopathy, Dilated - complications ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - metabolism ; Heart failure ; Heart Ventricles - metabolism ; Humans ; Metabolic Clearance Rate ; Metabolic Diseases - diagnostic imaging ; Metabolic Diseases - metabolism ; metabolism ; Middle Aged ; Myocardial Ischemia - complications ; Myocardial Ischemia - diagnostic imaging ; Myocardial Ischemia - metabolism ; Myocardium - metabolism ; Oxygen - metabolism ; Oxygen Consumption ; positron emission tomography ; Radionuclide Imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - metabolism ; Ventricular Remodeling</subject><ispartof>Journal of nuclear cardiology, 2006-07, Vol.13 (4), p.544-553</ispartof><rights>2006 American Society of Nuclear Cardiology</rights><rights>American Society of Nuclear Cardiology 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-73b136ea6e1f3af7bbc5be1bbefe4770c36fa579b5345b20f3e9c1e32cf4a10b3</citedby><cites>FETCH-LOGICAL-c393t-73b136ea6e1f3af7bbc5be1bbefe4770c36fa579b5345b20f3e9c1e32cf4a10b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16919578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kronenberg, Marvin W.</creatorcontrib><creatorcontrib>Cohen, Gerald I.</creatorcontrib><creatorcontrib>Leonen, Marlo F.</creatorcontrib><creatorcontrib>Mladsi, Thomas A.</creatorcontrib><creatorcontrib>Di Carli, Marcelo F.</creatorcontrib><title>Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic dilated cardiomyopathy</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description>Nonischemic dilated cardiomyopathy (NIDCM) is associated with left ventricular remodeling, hypertrophy, and mitochondrial metabolic abnormalities in vitro. We evaluated the hypothesis that energy supply, as judged by the rate of myocardial oxidative metabolism, is inadequate to meet oxygen demand in patients with NIDCM compared with normal subjects.
We used positron emission tomography to determine the myocardial carbon 11 acetate decay rate (k
mono) as an index of energy supply, and we compared k
mono with the rate-pressure product (RPP) as an index of metabolic demand in 7 patients with NIDCM and 7 normal subjects. The mean k
mono value (SEM) was 0.060 ± 0.006 min
−1 in NIDCM patients versus 0.054 ± 0.002 in normal subjects (
P = not significant). The RPP was 9949 ± 931 beats/min
·
mm Hg in NIDCM patients and 6521 ± 476 in normal subjects (
P = .007). The relationship of k
mono to this index of demand (k
mono/RPP) was 6.2 × 10
−6 in NIDCM patients but was 8.5 × 10
−6 in normal subjects (
P = .003). Thus RPP, as an index of myocardial oxygen demand, was poorly matched by the rate of oxidative metabolism in those patients with NIDCM. The k
mono was closely related to RPP in normal subjects (
r = 0.83,
P = .02) but not in NIDCM patients. Furthermore, there was no significant relationship between k
mono and wall stress as another index of oxygen demand.
These results are consistent with a mitochondrial metabolic abnormality in heart failure. This metabolic mismatch detected by positron emission tomography may contribute to the pathophysiology of congestive heart failure and left ventricular remodeling.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiomyopathy, Dilated - complications</subject><subject>Cardiomyopathy, Dilated - diagnostic imaging</subject><subject>Cardiomyopathy, Dilated - metabolism</subject><subject>Heart failure</subject><subject>Heart Ventricles - metabolism</subject><subject>Humans</subject><subject>Metabolic Clearance Rate</subject><subject>Metabolic Diseases - diagnostic imaging</subject><subject>Metabolic Diseases - metabolism</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardium - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Consumption</subject><subject>positron emission tomography</subject><subject>Radionuclide Imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - metabolism</subject><subject>Ventricular Remodeling</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1u1DAUhS0EoqXwCpXFgl2CHcf2eAeqaEFq1Q2sLf_caDxK7GAnhbw9HmYQEhtWvpa-c-7VOQhdU9JSQsX7QxtXNzqTfdsRIlrSt4R0z9Al5axrBOf0eZ2JpA3jO3qBXpVyIIQoptRLdEGFoorL3SWKD1s6ugQz4vQzeLOEJ8ATLMamMThc1nket8bDZKLHGcYKpFj2YS44RDzXL8Sl4B9h2eOYYihuD1MV-lBR8Pi3eZq2VNH99hq9GMxY4M35vULfbj99vfnc3D_efbn5eN84ptjSSGYpE2AE0IGZQVrruAVqLQzQS0kcE4PhUlnOem47MjBQjgLr3NAbSiy7Qu9OvnNO31coi57qZTCOJkJaixY7KfpOdRV8-w94SGuO9TYte6LUTlJVIXGCXE6lZBj0nMNk8qYp0cc69EH_qUMf69Ck17WOKrw-u692Av9Xds6_Ah9OANQwngJkXVwN1IEPGdyifQr_2_ELbqui3g</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Kronenberg, Marvin W.</creator><creator>Cohen, Gerald I.</creator><creator>Leonen, Marlo F.</creator><creator>Mladsi, Thomas A.</creator><creator>Di Carli, Marcelo F.</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic dilated cardiomyopathy</title><author>Kronenberg, Marvin W. ; Cohen, Gerald I. ; Leonen, Marlo F. ; Mladsi, Thomas A. ; Di Carli, Marcelo F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-73b136ea6e1f3af7bbc5be1bbefe4770c36fa579b5345b20f3e9c1e32cf4a10b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiomyopathy, Dilated - complications</topic><topic>Cardiomyopathy, Dilated - diagnostic imaging</topic><topic>Cardiomyopathy, Dilated - metabolism</topic><topic>Heart failure</topic><topic>Heart Ventricles - metabolism</topic><topic>Humans</topic><topic>Metabolic Clearance Rate</topic><topic>Metabolic Diseases - diagnostic imaging</topic><topic>Metabolic Diseases - metabolism</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - complications</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardium - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Oxygen Consumption</topic><topic>positron emission tomography</topic><topic>Radionuclide Imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - metabolism</topic><topic>Ventricular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kronenberg, Marvin W.</creatorcontrib><creatorcontrib>Cohen, Gerald I.</creatorcontrib><creatorcontrib>Leonen, Marlo F.</creatorcontrib><creatorcontrib>Mladsi, Thomas A.</creatorcontrib><creatorcontrib>Di Carli, Marcelo F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kronenberg, Marvin W.</au><au>Cohen, Gerald I.</au><au>Leonen, Marlo F.</au><au>Mladsi, Thomas A.</au><au>Di Carli, Marcelo F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic dilated cardiomyopathy</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>13</volume><issue>4</issue><spage>544</spage><epage>553</epage><pages>544-553</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Nonischemic dilated cardiomyopathy (NIDCM) is associated with left ventricular remodeling, hypertrophy, and mitochondrial metabolic abnormalities in vitro. We evaluated the hypothesis that energy supply, as judged by the rate of myocardial oxidative metabolism, is inadequate to meet oxygen demand in patients with NIDCM compared with normal subjects.
We used positron emission tomography to determine the myocardial carbon 11 acetate decay rate (k
mono) as an index of energy supply, and we compared k
mono with the rate-pressure product (RPP) as an index of metabolic demand in 7 patients with NIDCM and 7 normal subjects. The mean k
mono value (SEM) was 0.060 ± 0.006 min
−1 in NIDCM patients versus 0.054 ± 0.002 in normal subjects (
P = not significant). The RPP was 9949 ± 931 beats/min
·
mm Hg in NIDCM patients and 6521 ± 476 in normal subjects (
P = .007). The relationship of k
mono to this index of demand (k
mono/RPP) was 6.2 × 10
−6 in NIDCM patients but was 8.5 × 10
−6 in normal subjects (
P = .003). Thus RPP, as an index of myocardial oxygen demand, was poorly matched by the rate of oxidative metabolism in those patients with NIDCM. The k
mono was closely related to RPP in normal subjects (
r = 0.83,
P = .02) but not in NIDCM patients. Furthermore, there was no significant relationship between k
mono and wall stress as another index of oxygen demand.
These results are consistent with a mitochondrial metabolic abnormality in heart failure. This metabolic mismatch detected by positron emission tomography may contribute to the pathophysiology of congestive heart failure and left ventricular remodeling.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16919578</pmid><doi>10.1016/j.nuclcard.2006.04.002</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - metabolism Heart failure Heart Ventricles - metabolism Humans Metabolic Clearance Rate Metabolic Diseases - diagnostic imaging Metabolic Diseases - metabolism metabolism Middle Aged Myocardial Ischemia - complications Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - metabolism Myocardium - metabolism Oxygen - metabolism Oxygen Consumption positron emission tomography Radionuclide Imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - metabolism Ventricular Remodeling |
| title | Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic dilated cardiomyopathy |
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