Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms
Recent data on the association between growth hormone (GH) and male and female reproductive processes, as well as the effects of GH on these processes and on some reproductive and non-reproductive disorders, and possible extra- and intracellular mediators of its action are reviewed. The available da...
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| Veröffentlicht in: | The veterinary journal (1997) 2005-11, Vol.170 (3), p.307-317 |
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| creator | Sirotkin, A.V. |
| description | Recent data on the association between growth hormone (GH) and male and female reproductive processes, as well as the effects of GH on these processes and on some reproductive and non-reproductive disorders, and possible extra- and intracellular mediators of its action are reviewed. The available data suggest that GH is an important endocrine and autocrine/paracrine regulator of reproduction. It controls proliferation, apoptosis, growth and differentiation and the secretory and generative activities of different reproductive organs. It also regulates their response to gonadotrophin-releasing hormone (GnRH) and gonadotropins.
Despite the effects of GH on the IGF/IGFBP (insulin-like growth factor binding protein) system, oxytocin, steroids, activin, gonadotropin and gonadotropin receptors, the majority of GH’s actions on the reproductive processes are probably mediated not by these substances but by specific GH receptors acting through cAMP/protein kinase A, protein kinase G, tyrosine kinase-, MAP kinase and CDC2 kinase-dependent intracellular mechanisms. Although GH treatments can increase the risk of some reproductive and non-reproductive disorders, they may be useful in improving gonadal function, inducing superovulation and in embryo production. |
| doi_str_mv | 10.1016/j.tvjl.2004.05.014 |
| format | Article |
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Despite the effects of GH on the IGF/IGFBP (insulin-like growth factor binding protein) system, oxytocin, steroids, activin, gonadotropin and gonadotropin receptors, the majority of GH’s actions on the reproductive processes are probably mediated not by these substances but by specific GH receptors acting through cAMP/protein kinase A, protein kinase G, tyrosine kinase-, MAP kinase and CDC2 kinase-dependent intracellular mechanisms. Although GH treatments can increase the risk of some reproductive and non-reproductive disorders, they may be useful in improving gonadal function, inducing superovulation and in embryo production.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2004.05.014</identifier><identifier>PMID: 16266845</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>activins ; animal reproduction ; Animals ; Apoptosis - drug effects ; Apoptosis - physiology ; biochemical pathways ; cAMP ; CDC2 kinase ; Cell Division - drug effects ; Cell Division - physiology ; cell physiology ; cyclic AMP ; Cyclic AMP - metabolism ; Cyclic AMP-Dependent Protein Kinases - metabolism ; Enzyme Activation ; Female ; females ; gonadotropin-releasing hormone ; gonadotropins ; Growth hormone ; Growth Hormone - pharmacology ; Growth Hormone - physiology ; human reproduction ; Insulin-like growth factor binding protein 3 ; insulin-like growth factor binding proteins ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - metabolism ; kinases ; literature reviews ; Male ; males ; MAP kinase ; Oxytocin ; Oxytocin - metabolism ; Protein kinase A ; Protein kinase G ; Reproduction - drug effects ; Reproduction - physiology ; reproductive disorders ; somatotropin ; steroids ; Tyrosine kinase</subject><ispartof>The veterinary journal (1997), 2005-11, Vol.170 (3), p.307-317</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-537555fe641bce1a401a4970b7ed693655a4ee46330f23a967059b0453a235253</citedby><cites>FETCH-LOGICAL-c444t-537555fe641bce1a401a4970b7ed693655a4ee46330f23a967059b0453a235253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2004.05.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16266845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sirotkin, A.V.</creatorcontrib><title>Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Recent data on the association between growth hormone (GH) and male and female reproductive processes, as well as the effects of GH on these processes and on some reproductive and non-reproductive disorders, and possible extra- and intracellular mediators of its action are reviewed. The available data suggest that GH is an important endocrine and autocrine/paracrine regulator of reproduction. It controls proliferation, apoptosis, growth and differentiation and the secretory and generative activities of different reproductive organs. It also regulates their response to gonadotrophin-releasing hormone (GnRH) and gonadotropins.
Despite the effects of GH on the IGF/IGFBP (insulin-like growth factor binding protein) system, oxytocin, steroids, activin, gonadotropin and gonadotropin receptors, the majority of GH’s actions on the reproductive processes are probably mediated not by these substances but by specific GH receptors acting through cAMP/protein kinase A, protein kinase G, tyrosine kinase-, MAP kinase and CDC2 kinase-dependent intracellular mechanisms. Although GH treatments can increase the risk of some reproductive and non-reproductive disorders, they may be useful in improving gonadal function, inducing superovulation and in embryo production.</description><subject>activins</subject><subject>animal reproduction</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>biochemical pathways</subject><subject>cAMP</subject><subject>CDC2 kinase</subject><subject>Cell Division - drug effects</subject><subject>Cell Division - physiology</subject><subject>cell physiology</subject><subject>cyclic AMP</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic AMP-Dependent Protein Kinases - metabolism</subject><subject>Enzyme Activation</subject><subject>Female</subject><subject>females</subject><subject>gonadotropin-releasing hormone</subject><subject>gonadotropins</subject><subject>Growth hormone</subject><subject>Growth Hormone - pharmacology</subject><subject>Growth Hormone - physiology</subject><subject>human reproduction</subject><subject>Insulin-like growth factor binding protein 3</subject><subject>insulin-like growth factor binding proteins</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>kinases</subject><subject>literature reviews</subject><subject>Male</subject><subject>males</subject><subject>MAP kinase</subject><subject>Oxytocin</subject><subject>Oxytocin - metabolism</subject><subject>Protein kinase A</subject><subject>Protein kinase G</subject><subject>Reproduction - drug effects</subject><subject>Reproduction - physiology</subject><subject>reproductive disorders</subject><subject>somatotropin</subject><subject>steroids</subject><subject>Tyrosine kinase</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAUhS1ExfsPsACvukt6_Qyp2FQjHpWQumiR2FmOc8N4lMRgJ9Py7_EwI3XHwvJdfOfo6CPknEHJgOlvq3Jar_qSA8gSVAlM7pEjpgQveF2x_XxDDQVwIQ7JcUorAKil5AfkkGmu9ZVUR-RpEcYphp6GjkZ8iaGd3eTXSPPpMCVMtHmjzzH8nZZ0GeIQRvxOb_5N0RbUji31OW4d9v3c20gHdEs7-jSkU_Kls33Cs91_Qh5vb_4s7ouHX3c_Fz8eCielnAolKqVUh1qyxiGzEvKrK2gqbHUttFJWIkotBHRc2FpXoOoGpBKWC8WVOCFft7158OuMaTKDT5s9dsQwJ6OvqtzNZAb5FnQxpBSxMy_RDza-GQZm49OszMan2fg0oAx8hC527XMzYPs_shOYgcst0Nlg7HP0yTz-5sAEMJCi5joT11sCs4W1x2iS8zg6bH1EN5k2-M8WvANYl4_B</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Sirotkin, A.V.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms</title><author>Sirotkin, A.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-537555fe641bce1a401a4970b7ed693655a4ee46330f23a967059b0453a235253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>activins</topic><topic>animal reproduction</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>biochemical pathways</topic><topic>cAMP</topic><topic>CDC2 kinase</topic><topic>Cell Division - drug effects</topic><topic>Cell Division - physiology</topic><topic>cell physiology</topic><topic>cyclic AMP</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic AMP-Dependent Protein Kinases - metabolism</topic><topic>Enzyme Activation</topic><topic>Female</topic><topic>females</topic><topic>gonadotropin-releasing hormone</topic><topic>gonadotropins</topic><topic>Growth hormone</topic><topic>Growth Hormone - pharmacology</topic><topic>Growth Hormone - physiology</topic><topic>human reproduction</topic><topic>Insulin-like growth factor binding protein 3</topic><topic>insulin-like growth factor binding proteins</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>kinases</topic><topic>literature reviews</topic><topic>Male</topic><topic>males</topic><topic>MAP kinase</topic><topic>Oxytocin</topic><topic>Oxytocin - metabolism</topic><topic>Protein kinase A</topic><topic>Protein kinase G</topic><topic>Reproduction - drug effects</topic><topic>Reproduction - physiology</topic><topic>reproductive disorders</topic><topic>somatotropin</topic><topic>steroids</topic><topic>Tyrosine kinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirotkin, A.V.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sirotkin, A.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>170</volume><issue>3</issue><spage>307</spage><epage>317</epage><pages>307-317</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>Recent data on the association between growth hormone (GH) and male and female reproductive processes, as well as the effects of GH on these processes and on some reproductive and non-reproductive disorders, and possible extra- and intracellular mediators of its action are reviewed. The available data suggest that GH is an important endocrine and autocrine/paracrine regulator of reproduction. It controls proliferation, apoptosis, growth and differentiation and the secretory and generative activities of different reproductive organs. It also regulates their response to gonadotrophin-releasing hormone (GnRH) and gonadotropins.
Despite the effects of GH on the IGF/IGFBP (insulin-like growth factor binding protein) system, oxytocin, steroids, activin, gonadotropin and gonadotropin receptors, the majority of GH’s actions on the reproductive processes are probably mediated not by these substances but by specific GH receptors acting through cAMP/protein kinase A, protein kinase G, tyrosine kinase-, MAP kinase and CDC2 kinase-dependent intracellular mechanisms. Although GH treatments can increase the risk of some reproductive and non-reproductive disorders, they may be useful in improving gonadal function, inducing superovulation and in embryo production.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16266845</pmid><doi>10.1016/j.tvjl.2004.05.014</doi><tpages>11</tpages></addata></record> |
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| subjects | activins animal reproduction Animals Apoptosis - drug effects Apoptosis - physiology biochemical pathways cAMP CDC2 kinase Cell Division - drug effects Cell Division - physiology cell physiology cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation Female females gonadotropin-releasing hormone gonadotropins Growth hormone Growth Hormone - pharmacology Growth Hormone - physiology human reproduction Insulin-like growth factor binding protein 3 insulin-like growth factor binding proteins Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism kinases literature reviews Male males MAP kinase Oxytocin Oxytocin - metabolism Protein kinase A Protein kinase G Reproduction - drug effects Reproduction - physiology reproductive disorders somatotropin steroids Tyrosine kinase |
| title | Control of reproductive processes by growth hormone: Extra- and intracellular mechanisms |
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