Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice
In this study, we demonstrated that Withania somnifera L. extract (WSE) protects mice from a lethal dose of Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenome...
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| Veröffentlicht in: | International immunopharmacology 2006-10, Vol.6 (10), p.1535-1542 |
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| creator | Teixeira, Silvia T. Valadares, Marize C. Gonçalves, Shirley A. de Melo, Adriana Queiroz, Mary L.S. |
| description | In this study, we demonstrated that
Withania somnifera L. extract (WSE) protects mice from a lethal dose of
Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with
L. monocytogenes, due to increased numbers of granulocyte–macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-γ) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-γ in mice infected with
L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages
Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-γ levels. |
| doi_str_mv | 10.1016/j.intimp.2006.03.016 |
| format | Article |
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Withania somnifera L. extract (WSE) protects mice from a lethal dose of
Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with
L. monocytogenes, due to increased numbers of granulocyte–macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-γ) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-γ in mice infected with
L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages
Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-γ levels.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2006.03.016</identifier><identifier>PMID: 16919825</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cell Proliferation - drug effects ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor - immunology ; Haematopoiesis ; Interferon-gamma ; Interferon-gamma - immunology ; Listeria monocytogenes ; Listeria monocytogenes - growth & development ; Listeriosis - immunology ; Listeriosis - microbiology ; Listeriosis - pathology ; Listeriosis - prevention & control ; Lymphocytes - cytology ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Male ; Mice ; Mice, Inbred BALB C ; Plant Extracts - isolation & purification ; Plant Extracts - therapeutic use ; Spleen - cytology ; Spleen - drug effects ; Spleen - immunology ; Withania - chemistry ; Withania somnifera L</subject><ispartof>International immunopharmacology, 2006-10, Vol.6 (10), p.1535-1542</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-d83033ec5206cf645be46b0cf2b619a71ab6aba36deb95041dbb9d2b668fc09d3</citedby><cites>FETCH-LOGICAL-c391t-d83033ec5206cf645be46b0cf2b619a71ab6aba36deb95041dbb9d2b668fc09d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2006.03.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16919825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teixeira, Silvia T.</creatorcontrib><creatorcontrib>Valadares, Marize C.</creatorcontrib><creatorcontrib>Gonçalves, Shirley A.</creatorcontrib><creatorcontrib>de Melo, Adriana</creatorcontrib><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><title>Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>In this study, we demonstrated that
Withania somnifera L. extract (WSE) protects mice from a lethal dose of
Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with
L. monocytogenes, due to increased numbers of granulocyte–macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-γ) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-γ in mice infected with
L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages
Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-γ levels.</description><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>Disease Models, Animal</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - immunology</subject><subject>Haematopoiesis</subject><subject>Interferon-gamma</subject><subject>Interferon-gamma - immunology</subject><subject>Listeria monocytogenes</subject><subject>Listeria monocytogenes - growth & development</subject><subject>Listeriosis - immunology</subject><subject>Listeriosis - microbiology</subject><subject>Listeriosis - pathology</subject><subject>Listeriosis - prevention & control</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - therapeutic use</subject><subject>Spleen - cytology</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>Withania - chemistry</subject><subject>Withania somnifera L</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2LFDEQDaK46-o_EMnJW7dJZzrdfRFkcdeFgfWgeAz5qHZqmE7GJCM7-OetZQa8uacU76OSvMfYWylaKaT-sG0xVlz2bSeEboVqCXzGLuU4jI0cRP-c5l4PTT_o6YK9KmUrBOEr-ZJdSD3Jaez6S_bna077zXFnfUXPbVgwYqnZVkyRp5n_wLqxES0vaYk4Q7YcHoj3lWP0GWyBwjepVJ6hkNNGD8TwNc2QybekmPyxpp8QSYlxBl8h8AU9vGYvZrsr8OZ8XrHvN5-_XX9p1ve3d9ef1o1Xk6xNGJVQCnzfCe1nveodrLQTfu6clpMdpHXaOqt0ADf19MHg3BSI1OPsxRTUFXt_2rvP6dcBSjULFg-7nY2QDsXocdBKdeOTQjnRSwatSbg6CX1OpWSYzT7jYvPRSGEe2zFbc2rHPLZjhDIEku3def_BLRD-mc51kODjSQAUx2-EbIpHoEgDZsrNhIT_v-EvDyqmvA</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Teixeira, Silvia T.</creator><creator>Valadares, Marize C.</creator><creator>Gonçalves, Shirley A.</creator><creator>de Melo, Adriana</creator><creator>Queiroz, Mary L.S.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice</title><author>Teixeira, Silvia T. ; Valadares, Marize C. ; Gonçalves, Shirley A. ; de Melo, Adriana ; Queiroz, Mary L.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-d83033ec5206cf645be46b0cf2b619a71ab6aba36deb95041dbb9d2b668fc09d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Cell Proliferation - drug effects</topic><topic>Disease Models, Animal</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - immunology</topic><topic>Haematopoiesis</topic><topic>Interferon-gamma</topic><topic>Interferon-gamma - immunology</topic><topic>Listeria monocytogenes</topic><topic>Listeria monocytogenes - growth & development</topic><topic>Listeriosis - immunology</topic><topic>Listeriosis - microbiology</topic><topic>Listeriosis - pathology</topic><topic>Listeriosis - prevention & control</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - therapeutic use</topic><topic>Spleen - cytology</topic><topic>Spleen - drug effects</topic><topic>Spleen - immunology</topic><topic>Withania - chemistry</topic><topic>Withania somnifera L</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teixeira, Silvia T.</creatorcontrib><creatorcontrib>Valadares, Marize C.</creatorcontrib><creatorcontrib>Gonçalves, Shirley A.</creatorcontrib><creatorcontrib>de Melo, Adriana</creatorcontrib><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teixeira, Silvia T.</au><au>Valadares, Marize C.</au><au>Gonçalves, Shirley A.</au><au>de Melo, Adriana</au><au>Queiroz, Mary L.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>6</volume><issue>10</issue><spage>1535</spage><epage>1542</epage><pages>1535-1542</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>In this study, we demonstrated that
Withania somnifera L. extract (WSE) protects mice from a lethal dose of
Listeria monocytogenes when administered prophylactically at 100, 250 and 500 mg/kg for 10 days, with survival rates up to 30%. These doses also prevented the myelosuppression and the splenomegaly caused by a sublethal infection with
L. monocytogenes, due to increased numbers of granulocyte–macrophage progenitors (CFU-GM) in the bone marrow. Investigation of the production of colony-stimulating factors (CSFs) revealed increased colony-stimulating activity (CSA) in the serum of normal and infected mice pre-treated with WSE. Further studies to investigate the levels of interferon-gamma (INF-γ) and lymphocyte cell proliferation were undertaken. We observed dose-dependent increases in cell proliferation and in the levels of INF-γ in mice infected with
L. monocytogenes and treated with WSE. All together, our results suggest that WSE indirectly modulates immune activity and probably disengages
Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow, proliferation of lymphocytes and increased INF-γ levels.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16919825</pmid><doi>10.1016/j.intimp.2006.03.016</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Cell Proliferation - drug effects Disease Models, Animal Granulocyte-Macrophage Colony-Stimulating Factor - immunology Haematopoiesis Interferon-gamma Interferon-gamma - immunology Listeria monocytogenes Listeria monocytogenes - growth & development Listeriosis - immunology Listeriosis - microbiology Listeriosis - pathology Listeriosis - prevention & control Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - immunology Male Mice Mice, Inbred BALB C Plant Extracts - isolation & purification Plant Extracts - therapeutic use Spleen - cytology Spleen - drug effects Spleen - immunology Withania - chemistry Withania somnifera L |
| title | Prophylactic administration of Withania somnifera extract increases host resistance in Listeria monocytogenes infected mice |
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