RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila

The mitochondrial iron chaperone, frataxin, plays a critical role in cellular iron homeostasis and the synthesis and regeneration of Fe–S centers. Genetic insufficiency for frataxin is associated with Friedreich's Ataxia in humans and confers loss of function of Fe-containing proteins including...

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Veröffentlicht in:	Human molecular genetics 2005-11, Vol.14 (22), p.3397-3405
Hauptverfasser:	Anderson, Peter R., Kirby, Kim, Hilliker, Arthur J., Phillips, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Body Size - genetics Catalase - physiology Cytosol - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - genetics Female Frataxin Fundamental and applied biological sciences. Psychology Gene Silencing Genetics of eukaryotes. Biological and molecular evolution Humans Iron - metabolism Iron-Binding Proteins - antagonists & inhibitors Iron-Binding Proteins - genetics Iron-Sulfur Proteins - metabolism Larva - genetics Larva - growth & development Larva - metabolism Male Mitochondria - metabolism Molecular and cellular biology Molecular Sequence Data Neurons - metabolism Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - genetics Pupa - genetics Pupa - growth & development Pupa - metabolism RNA Interference - physiology Superoxide Dismutase - physiology Superoxide Dismutase-1 Transgenes
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