Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography
As a chromatographic column, the high‐speed counter‐current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two‐phase solvent system was composed of...
Gespeichert in:
| Veröffentlicht in: | Journal of separation science 2006-07, Vol.29 (11), p.1653-1657 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1657 |
|---|---|
| container_issue | 11 |
| container_start_page | 1653 |
| container_title | Journal of separation science |
| container_volume | 29 |
| creator | Han, Quanbin Song, Jingzheng Qiao, Chunfeng Wong, Lina Xu, Hongxi |
| description | As a chromatographic column, the high‐speed counter‐current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two‐phase solvent system was composed of n‐hexane‐ethyl acetate‐methanol‐water (1 : 20 : 1 : 20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively. The chemical structures were identified by their MS and 1H NMR spectra. |
| doi_str_mv | 10.1002/jssc.200600089 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68762993</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68762993</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3279-3da112d182ab2fde4ea3027c8b44a3b2e7a08e3424d18e5c596aa39c9d8e0b133</originalsourceid><addsrcrecordid>eNpFkU1v1DAQhiNERUvhyhH5ArcUf2QT-wgrugVV_VCL4GZNnMnGxXGCnUDzR_p7yWo_evJ45nnmMG-SvGP0jFHKPz3EaM44pTmlVKoXyQnL2SJVgmUvDzXNj5PXMT5Qygqp6KvkmOWKcy6zk-TpJmAPAQb7F4mNnZurzpOuJs1Uhc5NEUqHZADvrY_ENFiODtbWEDC2IuCrXc_6fa8OXUvuMbTWg7Owd0g5kcaumzT2iLPVjX7AkJoxBPTDTM0aDN06QN9Mb5KjGlzEt7v3NPlx_vV-eZFeXq--LT9fplbwQqWiAsZ4xSSHktcVZgiC8sLIMstAlBwLoBJFxrOZwYVZqBxAKKMqibRkQpwmH7d7-9D9GTEOurXRoHPgsRujzmWRc6U24PsdOJYtVroPtoUw6f0lZ-DDDoBowNUBvLHxmStUoVi-WaS23D_rcHqeU73JU2_y1Ic89fe7u-XhN7vp1rVxwMeDC-G3zgtRLPTPq5WWF6svV7fLX_pc_AdicqcH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68762993</pqid></control><display><type>article</type><title>Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Han, Quanbin ; Song, Jingzheng ; Qiao, Chunfeng ; Wong, Lina ; Xu, Hongxi</creator><creatorcontrib>Han, Quanbin ; Song, Jingzheng ; Qiao, Chunfeng ; Wong, Lina ; Xu, Hongxi</creatorcontrib><description>As a chromatographic column, the high‐speed counter‐current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two‐phase solvent system was composed of n‐hexane‐ethyl acetate‐methanol‐water (1 : 20 : 1 : 20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively. The chemical structures were identified by their MS and 1H NMR spectra.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.200600089</identifier><identifier>PMID: 16922284</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Analytical chemistry ; Benzopyrans - chemistry ; Benzopyrans - isolation & purification ; Biological and medical sciences ; Chebulagic acid ; Chebulinic acid ; Chemistry ; Chromatographic methods and physical methods associated with chromatography ; Chromatography, High Pressure Liquid ; Counter-current chromatography ; Countercurrent Distribution - methods ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - isolation & purification ; Exact sciences and technology ; General pharmacology ; Glucosides - chemistry ; Glucosides - isolation & purification ; Hydrolyzable tannin ; Hydrolyzable Tannins - chemistry ; Hydrolyzable Tannins - isolation & purification ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Other chromatographic methods ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Solvents ; Spectrometry, Mass, Fast Atom Bombardment ; Terminalia - chemistry ; Terminalia chebula</subject><ispartof>Journal of separation science, 2006-07, Vol.29 (11), p.1653-1657</ispartof><rights>Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.200600089$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.200600089$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17979163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16922284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Quanbin</creatorcontrib><creatorcontrib>Song, Jingzheng</creatorcontrib><creatorcontrib>Qiao, Chunfeng</creatorcontrib><creatorcontrib>Wong, Lina</creatorcontrib><creatorcontrib>Xu, Hongxi</creatorcontrib><title>Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography</title><title>Journal of separation science</title><addtitle>J. Sep. Science</addtitle><description>As a chromatographic column, the high‐speed counter‐current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two‐phase solvent system was composed of n‐hexane‐ethyl acetate‐methanol‐water (1 : 20 : 1 : 20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively. The chemical structures were identified by their MS and 1H NMR spectra.</description><subject>Analytical chemistry</subject><subject>Benzopyrans - chemistry</subject><subject>Benzopyrans - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Chebulagic acid</subject><subject>Chebulinic acid</subject><subject>Chemistry</subject><subject>Chromatographic methods and physical methods associated with chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Counter-current chromatography</subject><subject>Countercurrent Distribution - methods</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - isolation & purification</subject><subject>Hydrolyzable tannin</subject><subject>Hydrolyzable Tannins - chemistry</subject><subject>Hydrolyzable Tannins - isolation & purification</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Other chromatographic methods</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Solvents</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><subject>Terminalia - chemistry</subject><subject>Terminalia chebula</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhiNERUvhyhH5ArcUf2QT-wgrugVV_VCL4GZNnMnGxXGCnUDzR_p7yWo_evJ45nnmMG-SvGP0jFHKPz3EaM44pTmlVKoXyQnL2SJVgmUvDzXNj5PXMT5Qygqp6KvkmOWKcy6zk-TpJmAPAQb7F4mNnZurzpOuJs1Uhc5NEUqHZADvrY_ENFiODtbWEDC2IuCrXc_6fa8OXUvuMbTWg7Owd0g5kcaumzT2iLPVjX7AkJoxBPTDTM0aDN06QN9Mb5KjGlzEt7v3NPlx_vV-eZFeXq--LT9fplbwQqWiAsZ4xSSHktcVZgiC8sLIMstAlBwLoBJFxrOZwYVZqBxAKKMqibRkQpwmH7d7-9D9GTEOurXRoHPgsRujzmWRc6U24PsdOJYtVroPtoUw6f0lZ-DDDoBowNUBvLHxmStUoVi-WaS23D_rcHqeU73JU2_y1Ic89fe7u-XhN7vp1rVxwMeDC-G3zgtRLPTPq5WWF6svV7fLX_pc_AdicqcH</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Han, Quanbin</creator><creator>Song, Jingzheng</creator><creator>Qiao, Chunfeng</creator><creator>Wong, Lina</creator><creator>Xu, Hongxi</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography</title><author>Han, Quanbin ; Song, Jingzheng ; Qiao, Chunfeng ; Wong, Lina ; Xu, Hongxi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3279-3da112d182ab2fde4ea3027c8b44a3b2e7a08e3424d18e5c596aa39c9d8e0b133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analytical chemistry</topic><topic>Benzopyrans - chemistry</topic><topic>Benzopyrans - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Chebulagic acid</topic><topic>Chebulinic acid</topic><topic>Chemistry</topic><topic>Chromatographic methods and physical methods associated with chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Counter-current chromatography</topic><topic>Countercurrent Distribution - methods</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Glucosides - chemistry</topic><topic>Glucosides - isolation & purification</topic><topic>Hydrolyzable tannin</topic><topic>Hydrolyzable Tannins - chemistry</topic><topic>Hydrolyzable Tannins - isolation & purification</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Other chromatographic methods</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Solvents</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><topic>Terminalia - chemistry</topic><topic>Terminalia chebula</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Quanbin</creatorcontrib><creatorcontrib>Song, Jingzheng</creatorcontrib><creatorcontrib>Qiao, Chunfeng</creatorcontrib><creatorcontrib>Wong, Lina</creatorcontrib><creatorcontrib>Xu, Hongxi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Quanbin</au><au>Song, Jingzheng</au><au>Qiao, Chunfeng</au><au>Wong, Lina</au><au>Xu, Hongxi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography</atitle><jtitle>Journal of separation science</jtitle><addtitle>J. Sep. Science</addtitle><date>2006-07</date><risdate>2006</risdate><volume>29</volume><issue>11</issue><spage>1653</spage><epage>1657</epage><pages>1653-1657</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>As a chromatographic column, the high‐speed counter‐current chromatography system was equipped with a preparative HPLC series, enabling the successful isolation of hydrolysable tannins from the fruits of Terminalia chebula, a traditional Chinese medicine. The two‐phase solvent system was composed of n‐hexane‐ethyl acetate‐methanol‐water (1 : 20 : 1 : 20 v/v). As a result, 33.2 mg chebulagic and 15.8 mg chebulinic acids were obtained in one step from 300 mg of crude extract. Their purities were determined by HPLC to be 95.3 and 96.1%, respectively. The chemical structures were identified by their MS and 1H NMR spectra.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>16922284</pmid><doi>10.1002/jssc.200600089</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1615-9306 |
| ispartof | Journal of separation science, 2006-07, Vol.29 (11), p.1653-1657 |
| issn | 1615-9306 1615-9314 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68762993 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Analytical chemistry Benzopyrans - chemistry Benzopyrans - isolation & purification Biological and medical sciences Chebulagic acid Chebulinic acid Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid Counter-current chromatography Countercurrent Distribution - methods Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Exact sciences and technology General pharmacology Glucosides - chemistry Glucosides - isolation & purification Hydrolyzable tannin Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - isolation & purification Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Other chromatographic methods Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Solvents Spectrometry, Mass, Fast Atom Bombardment Terminalia - chemistry Terminalia chebula |
| title | Preparative isolation of hydrolysable tannins chebulagic acid and chebulinic acid from Terminalia chebula by high-speed counter-current chromatography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T18%3A20%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preparative%20isolation%20of%20hydrolysable%20tannins%20chebulagic%20acid%20and%20chebulinic%20acid%20from%20Terminalia%20chebula%20by%20high-speed%20counter-current%20chromatography&rft.jtitle=Journal%20of%20separation%20science&rft.au=Han,%20Quanbin&rft.date=2006-07&rft.volume=29&rft.issue=11&rft.spage=1653&rft.epage=1657&rft.pages=1653-1657&rft.issn=1615-9306&rft.eissn=1615-9314&rft_id=info:doi/10.1002/jssc.200600089&rft_dat=%3Cproquest_pubme%3E68762993%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68762993&rft_id=info:pmid/16922284&rfr_iscdi=true |