Down Modulation of TNF-α mRNA Placental Expression by AZT Used for the Prevention of HIV-1 Mother-to-Child Transmission

Mechanisms of HIV-1 in utero mother-to-child transmission (MTCT) protection provided by AZT are not completely understood. The placental cytokine network is involved in the control of HIV-1 in utero transmission but the effect of AZT on this network is unknown. To evaluate the effects of AZT on plac...

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Veröffentlicht in:	Placenta (Eastbourne) 2006-09, Vol.27 (9), p.989-995
Hauptverfasser:	Pornprasert, S., Faye, A., Mary, J.Y., Dolcini, G., Leechanachai, P., Chaouat, G., Ngo, N., Barré-Sinoussi, F., Menu, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology AZT Biological and medical sciences Chorionic Villi - drug effects Down-Regulation Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Histoculture HIV Infections - prevention & control HIV-1 HIV-1 - drug effects Humans Infectious Disease Transmission, Vertical - prevention & control Lipopolysaccharides Mother-to-child transmission Placenta - drug effects Placental cytokine expression Pregnancy Prevention RNA, Messenger - metabolism Tissue Culture Techniques Tumor Necrosis Factor-alpha - drug effects Zidovudine - pharmacology
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