Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia
We previously reported that the adiponectin-leptin (A/L) ratio was more efficacious as a parameter of insulin resistance than adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than homeostasis model assessment (HOMA-R) as the fasting plasma glucose (FPG) lev...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2006-09, Vol.55 (9), p.1248-1254 |
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| creator | Inoue, Minoru Yano, Masao Yamakado, Minoru Maehata, Eisuke Suzuki, Seiji |
| description | We previously reported that the adiponectin-leptin (A/L) ratio was more efficacious as a parameter of insulin resistance than adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than homeostasis model assessment (HOMA-R) as the fasting plasma glucose (FPG) level elevated in type 2 diabetes mellitus. In this study, we examined the usefulness of the A/L ratio as compared to HOMA-R for assessing insulin resistance in Japanese subjects without hyperglycemia. A total of 411 Japanese adults without hyperglycemia (205 men, aged 49 ± 10 years; 206 women, aged 48 ± 10 years) were enrolled. We investigated the correlation between fasting serum insulin level, FPG, leptin or adiponectin, and body mass index (BMI), fat mass (FM), triglycerides (TGs), high-density lipoprotein (HDL) cholesterol, or preheparin serum lipoprotein lipase (LPL) as parameters of insulin resistance. Next, we examined the relationships between parameters of insulin resistance and the A/L ratio or HOMA-R. By simple regression of the correlation between serum insulin level, FPG, leptin or adiponectin, and each parameter of insulin resistance, the best correlation coefficients were seen in leptin (men,
r = 0.501; women,
r = 0.667) as compared with BMI, in leptin (men,
r = 0.658; women,
r = 0.747) as compared with FM, in adiponectin (
r = −0.285) in men and leptin (
r = 0.299) in women as compared with TGs, in adiponectin (men,
r = 0.405; women;
r = 0.442) as compared with HDL cholesterol, and in adiponectin (men,
r = 0.228; women,
r = 0.452) as compared with LPL. By simple regression of the correlation between A/L ratio or HOMA-R and each parameter of insulin resistance, the highest correlation coefficients were seen with the A/L ratio except HDL cholesterol in men. Next, we carried out multiple linear regression to analyze the association between A/L ratio or HOMA-R and FM, TGs, HDL cholesterol, and LPL, excluding BMI, simultaneously. In men, the A/L ratio was significantly correlated with FM and TGs, and HOMA-R was significantly correlated with FM. This model explained 34% of the variance in the A/L ratio and 17% of the variance in HOMA-R. In women, the A/L ratio was significantly correlated with FM and LPL, and HOMA-R was significantly correlated with FM and LPL. This model explained 39% of the variance in A/L ratio and 14% of the variance in HOMA-R. In conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accuratel |
| doi_str_mv | 10.1016/j.metabol.2006.05.010 |
| format | Article |
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r = 0.501; women,
r = 0.667) as compared with BMI, in leptin (men,
r = 0.658; women,
r = 0.747) as compared with FM, in adiponectin (
r = −0.285) in men and leptin (
r = 0.299) in women as compared with TGs, in adiponectin (men,
r = 0.405; women;
r = 0.442) as compared with HDL cholesterol, and in adiponectin (men,
r = 0.228; women,
r = 0.452) as compared with LPL. By simple regression of the correlation between A/L ratio or HOMA-R and each parameter of insulin resistance, the highest correlation coefficients were seen with the A/L ratio except HDL cholesterol in men. Next, we carried out multiple linear regression to analyze the association between A/L ratio or HOMA-R and FM, TGs, HDL cholesterol, and LPL, excluding BMI, simultaneously. In men, the A/L ratio was significantly correlated with FM and TGs, and HOMA-R was significantly correlated with FM. This model explained 34% of the variance in the A/L ratio and 17% of the variance in HOMA-R. In women, the A/L ratio was significantly correlated with FM and LPL, and HOMA-R was significantly correlated with FM and LPL. This model explained 39% of the variance in A/L ratio and 14% of the variance in HOMA-R. In conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accurately assess insulin resistance in subjects without hyperglycemia.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2006.05.010</identifier><identifier>PMID: 16919546</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adiponectin - blood ; Adult ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - analysis ; Female ; Humans ; Hyperglycemia - blood ; Insulin - blood ; Insulin Resistance ; Japan - epidemiology ; Leptin - blood ; Lipids - analysis ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged</subject><ispartof>Metabolism, clinical and experimental, 2006-09, Vol.55 (9), p.1248-1254</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-dbb69c974cb90dfcb4c59906d5beff9186323e076d1bbe83b7eca05383fada173</citedby><cites>FETCH-LOGICAL-c374t-dbb69c974cb90dfcb4c59906d5beff9186323e076d1bbe83b7eca05383fada173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049506001776$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18107149$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16919546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Minoru</creatorcontrib><creatorcontrib>Yano, Masao</creatorcontrib><creatorcontrib>Yamakado, Minoru</creatorcontrib><creatorcontrib>Maehata, Eisuke</creatorcontrib><creatorcontrib>Suzuki, Seiji</creatorcontrib><title>Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>We previously reported that the adiponectin-leptin (A/L) ratio was more efficacious as a parameter of insulin resistance than adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than homeostasis model assessment (HOMA-R) as the fasting plasma glucose (FPG) level elevated in type 2 diabetes mellitus. In this study, we examined the usefulness of the A/L ratio as compared to HOMA-R for assessing insulin resistance in Japanese subjects without hyperglycemia. A total of 411 Japanese adults without hyperglycemia (205 men, aged 49 ± 10 years; 206 women, aged 48 ± 10 years) were enrolled. We investigated the correlation between fasting serum insulin level, FPG, leptin or adiponectin, and body mass index (BMI), fat mass (FM), triglycerides (TGs), high-density lipoprotein (HDL) cholesterol, or preheparin serum lipoprotein lipase (LPL) as parameters of insulin resistance. Next, we examined the relationships between parameters of insulin resistance and the A/L ratio or HOMA-R. By simple regression of the correlation between serum insulin level, FPG, leptin or adiponectin, and each parameter of insulin resistance, the best correlation coefficients were seen in leptin (men,
r = 0.501; women,
r = 0.667) as compared with BMI, in leptin (men,
r = 0.658; women,
r = 0.747) as compared with FM, in adiponectin (
r = −0.285) in men and leptin (
r = 0.299) in women as compared with TGs, in adiponectin (men,
r = 0.405; women;
r = 0.442) as compared with HDL cholesterol, and in adiponectin (men,
r = 0.228; women,
r = 0.452) as compared with LPL. By simple regression of the correlation between A/L ratio or HOMA-R and each parameter of insulin resistance, the highest correlation coefficients were seen with the A/L ratio except HDL cholesterol in men. Next, we carried out multiple linear regression to analyze the association between A/L ratio or HOMA-R and FM, TGs, HDL cholesterol, and LPL, excluding BMI, simultaneously. In men, the A/L ratio was significantly correlated with FM and TGs, and HOMA-R was significantly correlated with FM. This model explained 34% of the variance in the A/L ratio and 17% of the variance in HOMA-R. In women, the A/L ratio was significantly correlated with FM and LPL, and HOMA-R was significantly correlated with FM and LPL. This model explained 39% of the variance in A/L ratio and 14% of the variance in HOMA-R. In conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accurately assess insulin resistance in subjects without hyperglycemia.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperglycemia - blood</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Japan - epidemiology</subject><subject>Leptin - blood</subject><subject>Lipids - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwD5AreEcT6c-IRQBRSpUiXUni1_TFivnA9sh3b_PV42Uo-cRpp53pnRQ8g7BiUDxj8dyhGT0rMvKwBeQlsCgxdkx9q6KnoO8JLsACpeQCPaC3IZ4wEAuq7nr8kF44KJtuE78vQTvUpunuLeLVRjekScaNojVdYt84QmuanwuORCw4mkarJ0UUHl-xginQfqprj60xyji0lNBnOLxlUfcjzSR5f285ro_rhg-OWPBken3pBXg_IR3271ijx8-3p_fVPc3n3_cf3ltjB116TCas2FEV1jtAA7GN2YVgjgttU4DIL1vK5qhI5bpjX2te7QKGjrvh6UVayrr8jH894lzL9XjEmOLhr0Xk04r1HyvuNVxSCD7Rk0YY4x4CCX4EYVjpKBPCmXB7kplyflEloJ_3LvtwOrHtE-pzbHGfiwASoa5YeQBbn4zPUMOtaIzH0-c5h1_HEYZDQOs0zrQvYo7ez-88pf8p2mJQ</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Inoue, Minoru</creator><creator>Yano, Masao</creator><creator>Yamakado, Minoru</creator><creator>Maehata, Eisuke</creator><creator>Suzuki, Seiji</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia</title><author>Inoue, Minoru ; Yano, Masao ; Yamakado, Minoru ; Maehata, Eisuke ; Suzuki, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-dbb69c974cb90dfcb4c59906d5beff9186323e076d1bbe83b7eca05383fada173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperglycemia - blood</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Japan - epidemiology</topic><topic>Leptin - blood</topic><topic>Lipids - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Minoru</creatorcontrib><creatorcontrib>Yano, Masao</creatorcontrib><creatorcontrib>Yamakado, Minoru</creatorcontrib><creatorcontrib>Maehata, Eisuke</creatorcontrib><creatorcontrib>Suzuki, Seiji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Minoru</au><au>Yano, Masao</au><au>Yamakado, Minoru</au><au>Maehata, Eisuke</au><au>Suzuki, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2006-09</date><risdate>2006</risdate><volume>55</volume><issue>9</issue><spage>1248</spage><epage>1254</epage><pages>1248-1254</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>We previously reported that the adiponectin-leptin (A/L) ratio was more efficacious as a parameter of insulin resistance than adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than homeostasis model assessment (HOMA-R) as the fasting plasma glucose (FPG) level elevated in type 2 diabetes mellitus. In this study, we examined the usefulness of the A/L ratio as compared to HOMA-R for assessing insulin resistance in Japanese subjects without hyperglycemia. A total of 411 Japanese adults without hyperglycemia (205 men, aged 49 ± 10 years; 206 women, aged 48 ± 10 years) were enrolled. We investigated the correlation between fasting serum insulin level, FPG, leptin or adiponectin, and body mass index (BMI), fat mass (FM), triglycerides (TGs), high-density lipoprotein (HDL) cholesterol, or preheparin serum lipoprotein lipase (LPL) as parameters of insulin resistance. Next, we examined the relationships between parameters of insulin resistance and the A/L ratio or HOMA-R. By simple regression of the correlation between serum insulin level, FPG, leptin or adiponectin, and each parameter of insulin resistance, the best correlation coefficients were seen in leptin (men,
r = 0.501; women,
r = 0.667) as compared with BMI, in leptin (men,
r = 0.658; women,
r = 0.747) as compared with FM, in adiponectin (
r = −0.285) in men and leptin (
r = 0.299) in women as compared with TGs, in adiponectin (men,
r = 0.405; women;
r = 0.442) as compared with HDL cholesterol, and in adiponectin (men,
r = 0.228; women,
r = 0.452) as compared with LPL. By simple regression of the correlation between A/L ratio or HOMA-R and each parameter of insulin resistance, the highest correlation coefficients were seen with the A/L ratio except HDL cholesterol in men. Next, we carried out multiple linear regression to analyze the association between A/L ratio or HOMA-R and FM, TGs, HDL cholesterol, and LPL, excluding BMI, simultaneously. In men, the A/L ratio was significantly correlated with FM and TGs, and HOMA-R was significantly correlated with FM. This model explained 34% of the variance in the A/L ratio and 17% of the variance in HOMA-R. In women, the A/L ratio was significantly correlated with FM and LPL, and HOMA-R was significantly correlated with FM and LPL. This model explained 39% of the variance in A/L ratio and 14% of the variance in HOMA-R. In conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accurately assess insulin resistance in subjects without hyperglycemia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16919546</pmid><doi>10.1016/j.metabol.2006.05.010</doi><tpages>7</tpages></addata></record> |
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| subjects | Adiponectin - blood Adult Biological and medical sciences Biomarkers - blood Blood Glucose - analysis Female Humans Hyperglycemia - blood Insulin - blood Insulin Resistance Japan - epidemiology Leptin - blood Lipids - analysis Male Medical sciences Metabolic diseases Middle Aged |
| title | Relationship between the adiponectin-leptin ratio and parameters of insulin resistance in subjects without hyperglycemia |
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