Multiple Roles for Cyclin G‐Associated Kinase in Clathrin‐Mediated Sorting Events

Cyclin G‐associated kinase (GAK), also known as auxilin 2, is a potential regulator of clathrin‐mediated membrane trafficking. It possesses a kinase domain at its N‐terminus that can phosphorylate the clathrin adaptors AP‐1 and AP‐2 in vitro. The GAK C‐terminus can act as a cochaperaone in vitro for...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Denmark), 2005-12, Vol.6 (12), p.1103-1113
Hauptverfasser:	Zhang, Claire X., Engqvist‐Goldstein, Åsa E. Y., Carreno, Sebastien, Owen, David J., Smythe, Elizabeth, Drubin, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AP‐2 auxilin Cathepsin D - metabolism clathrin Clathrin - physiology Cyclins - deficiency Cyclins - genetics Cyclins - physiology endocytosis HeLa Cells Humans Lysosomes - metabolism Phosphorylation Protein Structure, Tertiary Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Rats RNA Interference TGN Threonine - genetics Threonine - metabolism trans-Golgi Network - metabolism Transferrin - metabolism
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