Spectrophotometric determination of certain antidepressants in pharmaceutical preparations
Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or...
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| Veröffentlicht in: | Journal of AOAC International 2006-07, Vol.89 (4), p.966-971 |
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| container_title | Journal of AOAC International |
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| creator | ÖNAL, Armagan KEPEKCI, S. Evrim CETIN, S. Müge ERTÜRK, Sidika |
| description | Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or bromophenol blue) to produce yellow-colored ion-pair complexes in acidic buffers. After extracting in chloroform, the ion-pair complexes are spectrophotometrically determined at the optimum wavelength. Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 microg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods. |
| doi_str_mv | 10.1093/jaoac/89.4.966 |
| format | Article |
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Evrim ; CETIN, S. Müge ; ERTÜRK, Sidika</creator><creatorcontrib>ÖNAL, Armagan ; KEPEKCI, S. Evrim ; CETIN, S. Müge ; ERTÜRK, Sidika</creatorcontrib><description>Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or bromophenol blue) to produce yellow-colored ion-pair complexes in acidic buffers. After extracting in chloroform, the ion-pair complexes are spectrophotometrically determined at the optimum wavelength. Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 microg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods.</description><identifier>ISSN: 1060-3271</identifier><identifier>EISSN: 1944-7922</identifier><identifier>DOI: 10.1093/jaoac/89.4.966</identifier><identifier>PMID: 16915831</identifier><language>eng</language><publisher>Gaithersburg, MD: AOAC International</publisher><subject>Antidepressants ; Antidepressive Agents - analysis ; Antidepressive Agents - pharmacology ; Biological and medical sciences ; Bromcresol Green - analysis ; Bromphenol Blue - analysis ; Bromthymol Blue - analysis ; Chemistry, Pharmaceutical - methods ; Cyclohexanols - analysis ; Drugs ; Fluoxetine - analysis ; Food industries ; Fundamental and applied biological sciences. Psychology ; Hydrogen-Ion Concentration ; Identification and classification ; Measurement ; Methods ; Product/Service Evaluations ; Reference Standards ; Reproducibility of Results ; Sensitivity and Specificity ; Sertraline - analysis ; Spectrophotometry ; Spectrophotometry - methods ; Venlafaxine Hydrochloride</subject><ispartof>Journal of AOAC International, 2006-07, Vol.89 (4), p.966-971</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2006 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-37024b7da4500971d64f3e2b68616496d5728ea2954b972c5cbfcc68775b61933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17997081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16915831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ÖNAL, Armagan</creatorcontrib><creatorcontrib>KEPEKCI, S. Evrim</creatorcontrib><creatorcontrib>CETIN, S. Müge</creatorcontrib><creatorcontrib>ERTÜRK, Sidika</creatorcontrib><title>Spectrophotometric determination of certain antidepressants in pharmaceutical preparations</title><title>Journal of AOAC International</title><addtitle>J AOAC Int</addtitle><description>Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or bromophenol blue) to produce yellow-colored ion-pair complexes in acidic buffers. After extracting in chloroform, the ion-pair complexes are spectrophotometrically determined at the optimum wavelength. Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 microg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods.</description><subject>Antidepressants</subject><subject>Antidepressive Agents - analysis</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bromcresol Green - analysis</subject><subject>Bromphenol Blue - analysis</subject><subject>Bromthymol Blue - analysis</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Cyclohexanols - analysis</subject><subject>Drugs</subject><subject>Fluoxetine - analysis</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Identification and classification</subject><subject>Measurement</subject><subject>Methods</subject><subject>Product/Service Evaluations</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Sertraline - analysis</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry - methods</subject><subject>Venlafaxine Hydrochloride</subject><issn>1060-3271</issn><issn>1944-7922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0T1P3TAUBmALgYDSrowoEqJbLv6KP0aESlsJqUPbpYt14pyAURIH23fov8cXrsSCPNg6fo5t-SXknNENo1ZcP0EEf23sRm6sUgfklFkpW205P6xrqmgruGYn5FPOT5RKpig_JidMWdYZwU7Jv98r-pLi-hhLnLGk4JsBC6Y5LFBCXJo4Nh5TgbA0sJQw4Jow57rMTS2tj5Bm8LgtwcPU1L0V0mtj_kyORpgyftnPZ-Tv3bc_tz_a-1_ff97e3LdeWlVaoSmXvR5AdpRazQYlR4G8V0YxVcXQaW4QuO1kbzX3ne9H75XRuusVs0Kcka9v564pPm8xFzeH7HGaYMG4za5SRYU1FV6-wQeY0IVljCWB32F3w7S12gi1U5sPVB0DzsHHBcdQ6x81-BRzTji6NYUZ0n_HqNuF5F5DcsY66WpIteFi_-BtP-PwzvepVHC1B5Drr44JFh_yu9tdTQ0TL0u-mxk</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>ÖNAL, Armagan</creator><creator>KEPEKCI, S. 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Psychology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Identification and classification</topic><topic>Measurement</topic><topic>Methods</topic><topic>Product/Service Evaluations</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Sertraline - analysis</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry - methods</topic><topic>Venlafaxine Hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ÖNAL, Armagan</creatorcontrib><creatorcontrib>KEPEKCI, S. Evrim</creatorcontrib><creatorcontrib>CETIN, S. 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Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 microg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods.</abstract><cop>Gaithersburg, MD</cop><pub>AOAC International</pub><pmid>16915831</pmid><doi>10.1093/jaoac/89.4.966</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1060-3271 |
| ispartof | Journal of AOAC International, 2006-07, Vol.89 (4), p.966-971 |
| issn | 1060-3271 1944-7922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68760398 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antidepressants Antidepressive Agents - analysis Antidepressive Agents - pharmacology Biological and medical sciences Bromcresol Green - analysis Bromphenol Blue - analysis Bromthymol Blue - analysis Chemistry, Pharmaceutical - methods Cyclohexanols - analysis Drugs Fluoxetine - analysis Food industries Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Identification and classification Measurement Methods Product/Service Evaluations Reference Standards Reproducibility of Results Sensitivity and Specificity Sertraline - analysis Spectrophotometry Spectrophotometry - methods Venlafaxine Hydrochloride |
| title | Spectrophotometric determination of certain antidepressants in pharmaceutical preparations |
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