Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates

Nitric oxide (NO) is synthesized from l-arginine by NO synthase in virtually all cell types. Emerging evidence shows that NO regulates the metabolism of glucose, fatty acids and amino acids in mammals. As an oxidant, pathological levels of NO inhibit nearly all enzyme-catalyzed reactions through pro...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2006-09, Vol.17 (9), p.571-588
Hauptverfasser:	Jobgen, Wenjuan Shi, Fried, Susan K., Fu, Wenjiang J., Meininger, Cynthia J., Wu, Guoyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism amino acid metabolism Amino acids Amino Acids - metabolism AMP-Activated Protein Kinases Animals arginine Arginine - metabolism Biological and medical sciences disease prevention energy balance energy metabolism Energy Metabolism - physiology enzyme activity Fatty Acids - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Glucose Glucose - metabolism glucose tolerance Glycolysis - drug effects Humans Intestine, Small - metabolism Lipid Lipid Metabolism - drug effects lipogenesis lipolysis Lipolysis - physiology Liver - metabolism mammals metabolic syndrome Metabolic Syndrome - physiopathology Mitochondria Mitochondria - physiology Multienzyme Complexes - metabolism Muscle, Skeletal - metabolism Myocardium - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide - physiology nitric oxide synthase Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism nutrition-genotype interaction nutritional intervention obesity overweight oxidants Oxidation oxidative stress protein supplements Protein-Serine-Threonine Kinases - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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