Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Neuroplastic processes are thought to be involved in the pathophysiology of many psychiatric disorders, including major depression. It has been hypothesized that the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is associated with depressive disorders. Our study evaluate...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2006-09, Vol.30 (7), p.1256-1260 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Aydemir, Cigdem Yalcin, Esra Süer Aksaray, Sabahat Kisa, Cebrail Yildirim, Sema Gulen Uzbay, Tayfun Goka, Erol |
| description | Neuroplastic processes are thought to be involved in the pathophysiology of many psychiatric disorders, including major depression. It has been hypothesized that the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is associated with depressive disorders.
Our study evaluated the pre- and post-treatment levels of BDNF in a group of depressed patients and compared them with healthy controls. In order to exclude the effects of gender on neuroplasticity, our study group was restricted to women exclusively and consisted of 20 depressive patients and 20 healthy controls, with similar age and educational level distribution. Blood samples were collected before the treatment and on the sixth week of the treatment with 10 mg
S-citalopram.
The pre-treatment BDNF levels of the depressed patients were found to be lower than those of the healthy subjects. During the sixth week, the BDNF levels of depressive patients were significantly higher than the pre-treatment levels but similar to those of control subjects.
These findings suggest that BDNF level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs. |
| doi_str_mv | 10.1016/j.pnpbp.2006.03.025 |
| format | Article |
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Our study evaluated the pre- and post-treatment levels of BDNF in a group of depressed patients and compared them with healthy controls. In order to exclude the effects of gender on neuroplasticity, our study group was restricted to women exclusively and consisted of 20 depressive patients and 20 healthy controls, with similar age and educational level distribution. Blood samples were collected before the treatment and on the sixth week of the treatment with 10 mg
S-citalopram.
The pre-treatment BDNF levels of the depressed patients were found to be lower than those of the healthy subjects. During the sixth week, the BDNF levels of depressive patients were significantly higher than the pre-treatment levels but similar to those of control subjects.
These findings suggest that BDNF level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2006.03.025</identifier><identifier>PMID: 16647794</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Antidepressive Agents, Second-Generation - therapeutic use ; Biological and medical sciences ; Brain-derived neurotrophic factor (BDNF) ; Brain-Derived Neurotrophic Factor - blood ; Case-Control Studies ; Citalopram - therapeutic use ; Depression ; Depression - blood ; Depression - drug therapy ; Female ; Humans ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Statistics, Nonparametric ; Time Factors</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2006-09, Vol.30 (7), p.1256-1260</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-212de779257f4685854c05102e51b2dd173643536ea36a8ad5bf9f2c547179583</citedby><cites>FETCH-LOGICAL-c453t-212de779257f4685854c05102e51b2dd173643536ea36a8ad5bf9f2c547179583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278584606001072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18049986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16647794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydemir, Cigdem</creatorcontrib><creatorcontrib>Yalcin, Esra Süer</creatorcontrib><creatorcontrib>Aksaray, Sabahat</creatorcontrib><creatorcontrib>Kisa, Cebrail</creatorcontrib><creatorcontrib>Yildirim, Sema Gulen</creatorcontrib><creatorcontrib>Uzbay, Tayfun</creatorcontrib><creatorcontrib>Goka, Erol</creatorcontrib><title>Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Neuroplastic processes are thought to be involved in the pathophysiology of many psychiatric disorders, including major depression. It has been hypothesized that the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is associated with depressive disorders.
Our study evaluated the pre- and post-treatment levels of BDNF in a group of depressed patients and compared them with healthy controls. In order to exclude the effects of gender on neuroplasticity, our study group was restricted to women exclusively and consisted of 20 depressive patients and 20 healthy controls, with similar age and educational level distribution. Blood samples were collected before the treatment and on the sixth week of the treatment with 10 mg
S-citalopram.
The pre-treatment BDNF levels of the depressed patients were found to be lower than those of the healthy subjects. During the sixth week, the BDNF levels of depressive patients were significantly higher than the pre-treatment levels but similar to those of control subjects.
These findings suggest that BDNF level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antidepressive Agents, Second-Generation - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain-derived neurotrophic factor (BDNF)</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Case-Control Studies</subject><subject>Citalopram - therapeutic use</subject><subject>Depression</subject><subject>Depression - blood</subject><subject>Depression - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Statistics, Nonparametric</subject><subject>Time Factors</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1EBQvlFyBVvlDRQ1J_xzn0UGgpSIj2UM6W1550vdrYwU5A_ffNsitx62nm8LzvjB6EzimpKaHq87oe4rAcakaIqgmvCZMHaEF1oyvBqDpEC8LmXWqhjtFJKWtCCOWEH6FjqpRomlYs0K-rbEOsPOTwDB5HmHIacxpWweHOujFlfHn17eHmE3YrG_9AwSHicQW4QJ56nDrsYchQyhx-ST3E9-hdZzcFzvbzFD3efP99fVvd__xxd_31vnJC8rFilHmYX2Cy6YTSUkvhiKSEgaRL5j1tuBJccgWWK6utl8uu7ZiToqFNKzU_RR93vUNOTxOU0fShONhsbIQ0FaN0I1vZqhnkO9DlVEqGzgw59Db_NZSYrUizNq8izVakIdzMIufUh339tOzBv2X25mbgYg_Y4uymyza6UN44TUTb6u35LzsOZhnPAbIpLkB04EMGNxqfwn8f-Qfxy5B3</recordid><startdate>20060930</startdate><enddate>20060930</enddate><creator>Aydemir, Cigdem</creator><creator>Yalcin, Esra Süer</creator><creator>Aksaray, Sabahat</creator><creator>Kisa, Cebrail</creator><creator>Yildirim, Sema Gulen</creator><creator>Uzbay, Tayfun</creator><creator>Goka, Erol</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060930</creationdate><title>Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women</title><author>Aydemir, Cigdem ; Yalcin, Esra Süer ; Aksaray, Sabahat ; Kisa, Cebrail ; Yildirim, Sema Gulen ; Uzbay, Tayfun ; Goka, Erol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-212de779257f4685854c05102e51b2dd173643536ea36a8ad5bf9f2c547179583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antidepressive Agents, Second-Generation - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain-derived neurotrophic factor (BDNF)</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Case-Control Studies</topic><topic>Citalopram - therapeutic use</topic><topic>Depression</topic><topic>Depression - blood</topic><topic>Depression - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Statistics, Nonparametric</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydemir, Cigdem</creatorcontrib><creatorcontrib>Yalcin, Esra Süer</creatorcontrib><creatorcontrib>Aksaray, Sabahat</creatorcontrib><creatorcontrib>Kisa, Cebrail</creatorcontrib><creatorcontrib>Yildirim, Sema Gulen</creatorcontrib><creatorcontrib>Uzbay, Tayfun</creatorcontrib><creatorcontrib>Goka, Erol</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydemir, Cigdem</au><au>Yalcin, Esra Süer</au><au>Aksaray, Sabahat</au><au>Kisa, Cebrail</au><au>Yildirim, Sema Gulen</au><au>Uzbay, Tayfun</au><au>Goka, Erol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2006-09-30</date><risdate>2006</risdate><volume>30</volume><issue>7</issue><spage>1256</spage><epage>1260</epage><pages>1256-1260</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Neuroplastic processes are thought to be involved in the pathophysiology of many psychiatric disorders, including major depression. It has been hypothesized that the brain-derived neurotrophic factor (BNDF), a key factor in neuroplasticity, is associated with depressive disorders.
Our study evaluated the pre- and post-treatment levels of BDNF in a group of depressed patients and compared them with healthy controls. In order to exclude the effects of gender on neuroplasticity, our study group was restricted to women exclusively and consisted of 20 depressive patients and 20 healthy controls, with similar age and educational level distribution. Blood samples were collected before the treatment and on the sixth week of the treatment with 10 mg
S-citalopram.
The pre-treatment BDNF levels of the depressed patients were found to be lower than those of the healthy subjects. During the sixth week, the BDNF levels of depressive patients were significantly higher than the pre-treatment levels but similar to those of control subjects.
These findings suggest that BDNF level may be an important factor in the etiopathogenesis of depression and may have a role in the action mechanism of antidepressant drugs.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>16647794</pmid><doi>10.1016/j.pnpbp.2006.03.025</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Brain-derived neurotrophic factor (BDNF) Brain-Derived Neurotrophic Factor - blood Case-Control Studies Citalopram - therapeutic use Depression Depression - blood Depression - drug therapy Female Humans Medical sciences Middle Aged Mood disorders Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Statistics, Nonparametric Time Factors |
| title | Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women |
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