The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters
The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals...
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| Veröffentlicht in: | The Journal of nutritional biochemistry 2006-09, Vol.17 (9), p.597-603 |
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| creator | Bissonauth, Vishnee Chouinard, Yvan Marin, Johanne Leblanc, Nadine Richard, Denis Jacques, Hélène |
| description | The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (
n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9±0.1 mmol/L) than those who ingested either LA (0.6±0.1 mmol/L) or c9,t11 CLA isomer (0.7±0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters. |
| doi_str_mv | 10.1016/j.jnutbio.2005.10.010 |
| format | Article |
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n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9±0.1 mmol/L) than those who ingested either LA (0.6±0.1 mmol/L) or c9,t11 CLA isomer (0.7±0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters.</description><identifier>ISSN: 0955-2863</identifier><identifier>EISSN: 1873-4847</identifier><identifier>DOI: 10.1016/j.jnutbio.2005.10.010</identifier><identifier>PMID: 16481156</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; blood lipids ; Body composition ; Body Composition - drug effects ; cholesteremic effect ; Cholesterol, LDL - metabolism ; Conjugated linoleic acid ; Cricetinae ; dietary fat ; Dietary Fats - pharmacology ; experimental diets ; fat intake ; Fats - analysis ; feces ; Feces - chemistry ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Hamsters ; high density lipoprotein ; Isomers ; Linoleic Acids, Conjugated - pharmacology ; Lipid metabolism ; Lipid Metabolism - drug effects ; lipolysis ; Lipoproteins ; liver ; Liver - drug effects ; Liver - metabolism ; low density lipoprotein ; Male ; phospholipids ; stereoisomers ; triacylglycerols ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; very low density lipoprotein</subject><ispartof>The Journal of nutritional biochemistry, 2006-09, Vol.17 (9), p.597-603</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-10ceba01ff042d54eec4b0ba2a27f57690c93d33f3e2cfdfa3e444c39e3519f23</citedby><cites>FETCH-LOGICAL-c417t-10ceba01ff042d54eec4b0ba2a27f57690c93d33f3e2cfdfa3e444c39e3519f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0955286305002731$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18084196$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16481156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bissonauth, Vishnee</creatorcontrib><creatorcontrib>Chouinard, Yvan</creatorcontrib><creatorcontrib>Marin, Johanne</creatorcontrib><creatorcontrib>Leblanc, Nadine</creatorcontrib><creatorcontrib>Richard, Denis</creatorcontrib><creatorcontrib>Jacques, Hélène</creatorcontrib><title>The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters</title><title>The Journal of nutritional biochemistry</title><addtitle>J Nutr Biochem</addtitle><description>The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (
n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9±0.1 mmol/L) than those who ingested either LA (0.6±0.1 mmol/L) or c9,t11 CLA isomer (0.7±0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>blood lipids</subject><subject>Body composition</subject><subject>Body Composition - drug effects</subject><subject>cholesteremic effect</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Conjugated linoleic acid</subject><subject>Cricetinae</subject><subject>dietary fat</subject><subject>Dietary Fats - pharmacology</subject><subject>experimental diets</subject><subject>fat intake</subject><subject>Fats - analysis</subject><subject>feces</subject><subject>Feces - chemistry</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hamsters</subject><subject>high density lipoprotein</subject><subject>Isomers</subject><subject>Linoleic Acids, Conjugated - pharmacology</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>lipolysis</subject><subject>Lipoproteins</subject><subject>liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>phospholipids</subject><subject>stereoisomers</subject><subject>triacylglycerols</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>very low density lipoprotein</subject><issn>0955-2863</issn><issn>1873-4847</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1DAUBmALgei08AiAN7BqhnN8yWWFqhEFpJFY0K4txzlmPEriwc4U9e3JMJHKjpWl4--3rd-MvUFYI2D5cb_ej8epDXEtAPQ8WwPCM7bCupKFqlX1nK2g0boQdSkv2GXOewAQSpcv2QWWqkbU5Yo93O2Ik_fkpsyj5xPCtUPBN9sbHnIcKHEXh4NN1PHfYdpx11xPiP_ux5H34RA6PtBk29iHPHA7dryN3ePfcMxhCrMKI9_ZIU-U8iv2wts-0-tlvWL3t5_vNl-L7fcv3zY328IprKYCwVFrAb0HJTqtiJxqobXCisrrqmzANbKT0ksSznfeSlJKOdmQ1Nh4Ia_Yh_O5hxR_HSlPZgjZUd_bkeIxm7KudF3Vaob6DF2KOSfy5pDCYNOjQTCnws3eLIWbU-Gn8Vz4nHu7XHBsB-qeUkvDM3i_AJud7X2yowv5ydVQK2xO7t3ZeRuN_Zlmc_9DAEpABCErPYtPZ0FzYQ-Bksku0OioC2n-PtPF8J_H_gG6ban8</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Bissonauth, Vishnee</creator><creator>Chouinard, Yvan</creator><creator>Marin, Johanne</creator><creator>Leblanc, Nadine</creator><creator>Richard, Denis</creator><creator>Jacques, Hélène</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters</title><author>Bissonauth, Vishnee ; Chouinard, Yvan ; Marin, Johanne ; Leblanc, Nadine ; Richard, Denis ; Jacques, Hélène</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-10ceba01ff042d54eec4b0ba2a27f57690c93d33f3e2cfdfa3e444c39e3519f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>blood lipids</topic><topic>Body composition</topic><topic>Body Composition - drug effects</topic><topic>cholesteremic effect</topic><topic>Cholesterol, LDL - metabolism</topic><topic>Conjugated linoleic acid</topic><topic>Cricetinae</topic><topic>dietary fat</topic><topic>Dietary Fats - pharmacology</topic><topic>experimental diets</topic><topic>fat intake</topic><topic>Fats - analysis</topic><topic>feces</topic><topic>Feces - chemistry</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hamsters</topic><topic>high density lipoprotein</topic><topic>Isomers</topic><topic>Linoleic Acids, Conjugated - pharmacology</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>lipolysis</topic><topic>Lipoproteins</topic><topic>liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>low density lipoprotein</topic><topic>Male</topic><topic>phospholipids</topic><topic>stereoisomers</topic><topic>triacylglycerols</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>very low density lipoprotein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bissonauth, Vishnee</creatorcontrib><creatorcontrib>Chouinard, Yvan</creatorcontrib><creatorcontrib>Marin, Johanne</creatorcontrib><creatorcontrib>Leblanc, Nadine</creatorcontrib><creatorcontrib>Richard, Denis</creatorcontrib><creatorcontrib>Jacques, Hélène</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutritional biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bissonauth, Vishnee</au><au>Chouinard, Yvan</au><au>Marin, Johanne</au><au>Leblanc, Nadine</au><au>Richard, Denis</au><au>Jacques, Hélène</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters</atitle><jtitle>The Journal of nutritional biochemistry</jtitle><addtitle>J Nutr Biochem</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>17</volume><issue>9</issue><spage>597</spage><epage>603</epage><pages>597-603</pages><issn>0955-2863</issn><eissn>1873-4847</eissn><abstract>The objective of the present study was to examine the effects of two different isomers of conjugated linoleic acid (CLA), c9,t11 CLA and t10,c12 CLA, compared with linoleic acid (LA) used as control, on body composition, lipoprotein profile, hepatic lipids and fecal fat content in hamsters. Animals were assigned to the three diet groups (
n=15) during 28 days. The diet was composed of 2% of the experimental fat, and throughout the experimental protocol, the hamsters experienced similar food intake. No significant differences were noted in body weight gain among the three diet groups. However, the t10,c12 CLA-fed animals showed higher low-density lipoprotein cholesterol (LDL-C) concentrations (0.9±0.1 mmol/L) than those who ingested either LA (0.6±0.1 mmol/L) or c9,t11 CLA isomer (0.7±0.1 mmol/L), although the t10,c12 CLA consumption decreased hepatic cholesterol and triglycerides and increased fecal fat content compared with the other two groups. Under the present experimental conditions, the dietary c9,t11 CLA isomer showed no positive beneficial effect on plasma lipids. Furthermore, the t10,c12 CLA isomer induced undesirable higher LDL-C, although it reduced hepatic lipids and fat digestibility in hamsters.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16481156</pmid><doi>10.1016/j.jnutbio.2005.10.010</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences blood lipids Body composition Body Composition - drug effects cholesteremic effect Cholesterol, LDL - metabolism Conjugated linoleic acid Cricetinae dietary fat Dietary Fats - pharmacology experimental diets fat intake Fats - analysis feces Feces - chemistry Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Hamsters high density lipoprotein Isomers Linoleic Acids, Conjugated - pharmacology Lipid metabolism Lipid Metabolism - drug effects lipolysis Lipoproteins liver Liver - drug effects Liver - metabolism low density lipoprotein Male phospholipids stereoisomers triacylglycerols Vertebrates: anatomy and physiology, studies on body, several organs or systems very low density lipoprotein |
| title | The effects of t10,c12 CLA isomer compared with c9,t11 CLA isomer on lipid metabolism and body composition in hamsters |
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