Stability of Benzoyl Peroxide in Methyl Alcohol
The purpose of this study was to clarify the stability of benzoyl peroxide (BPO) in some solvents. BPO was dissolved in acetone, acetonitrile (AcCN) , 50% acetonitrile-50% distilled water (50% AcCN) , ethyl alcohol (EtOH) , and methyl alcohol (MeOH) . Solutions containing BPO were incubated for eigh...
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| Veröffentlicht in: | Dental Materials Journal 2006, Vol.25(2), pp.298-302 |
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| creator | HONGO, Toshio HIKAGE, Sakari SATO, Atsushige |
| description | The purpose of this study was to clarify the stability of benzoyl peroxide (BPO) in some solvents. BPO was dissolved in acetone, acetonitrile (AcCN) , 50% acetonitrile-50% distilled water (50% AcCN) , ethyl alcohol (EtOH) , and methyl alcohol (MeOH) . Solutions containing BPO were incubated for eight days at 25°C. In MeOH, BPO rapidly decomposed into benzoic acid (BA) and methyl benzoate (MeBA) time-dependently, whereas BPO in acetone, AcCN, and 50% AcCN was relatively stable. Although BPO in EtOH was slightly stable within the first 24 hours, it decomposed time-dependently such that BA and EtBA as decomposition products of BPO were produced. These results indicated that the stability of BPO in a solution was dependent on the solvent and the decomposition rate of BPO dissolved in MeOH was the fastest. These suggest that BPO can decompose even in lower-than-activation temperature by the solvent to use for its dissolution. |
| doi_str_mv | 10.4012/dmj.25.298 |
| format | Article |
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BPO was dissolved in acetone, acetonitrile (AcCN) , 50% acetonitrile-50% distilled water (50% AcCN) , ethyl alcohol (EtOH) , and methyl alcohol (MeOH) . Solutions containing BPO were incubated for eight days at 25°C. In MeOH, BPO rapidly decomposed into benzoic acid (BA) and methyl benzoate (MeBA) time-dependently, whereas BPO in acetone, AcCN, and 50% AcCN was relatively stable. Although BPO in EtOH was slightly stable within the first 24 hours, it decomposed time-dependently such that BA and EtBA as decomposition products of BPO were produced. These results indicated that the stability of BPO in a solution was dependent on the solvent and the decomposition rate of BPO dissolved in MeOH was the fastest. These suggest that BPO can decompose even in lower-than-activation temperature by the solvent to use for its dissolution.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.25.298</identifier><identifier>PMID: 16916233</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Acetone - chemistry ; Acetonitriles - chemistry ; Benzoates ; Benzoic Acid ; Benzoyl peroxide ; Benzoyl Peroxide - chemistry ; Centrifugation, Density Gradient ; Chromatography, High Pressure Liquid ; Composite Resins - chemistry ; Dentistry ; Drug Stability ; Ethanol - chemistry ; HPLC ; Methanol - chemistry ; Solvents - chemistry ; Stability ; Time Factors ; Water - chemistry</subject><ispartof>Dental Materials Journal, 2006, Vol.25(2), pp.298-302</ispartof><rights>2006 The Japanese Society for Dental Materials and Devices</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-27366c5721d6637b21e61cd49fe69679e16761f6a18049649fb9eba1367da07c3</citedby><cites>FETCH-LOGICAL-c568t-27366c5721d6637b21e61cd49fe69679e16761f6a18049649fb9eba1367da07c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16916233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HONGO, Toshio</creatorcontrib><creatorcontrib>HIKAGE, Sakari</creatorcontrib><creatorcontrib>SATO, Atsushige</creatorcontrib><title>Stability of Benzoyl Peroxide in Methyl Alcohol</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>The purpose of this study was to clarify the stability of benzoyl peroxide (BPO) in some solvents. BPO was dissolved in acetone, acetonitrile (AcCN) , 50% acetonitrile-50% distilled water (50% AcCN) , ethyl alcohol (EtOH) , and methyl alcohol (MeOH) . Solutions containing BPO were incubated for eight days at 25°C. In MeOH, BPO rapidly decomposed into benzoic acid (BA) and methyl benzoate (MeBA) time-dependently, whereas BPO in acetone, AcCN, and 50% AcCN was relatively stable. Although BPO in EtOH was slightly stable within the first 24 hours, it decomposed time-dependently such that BA and EtBA as decomposition products of BPO were produced. These results indicated that the stability of BPO in a solution was dependent on the solvent and the decomposition rate of BPO dissolved in MeOH was the fastest. These suggest that BPO can decompose even in lower-than-activation temperature by the solvent to use for its dissolution.</description><subject>Acetone - chemistry</subject><subject>Acetonitriles - chemistry</subject><subject>Benzoates</subject><subject>Benzoic Acid</subject><subject>Benzoyl peroxide</subject><subject>Benzoyl Peroxide - chemistry</subject><subject>Centrifugation, Density Gradient</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Composite Resins - chemistry</subject><subject>Dentistry</subject><subject>Drug Stability</subject><subject>Ethanol - chemistry</subject><subject>HPLC</subject><subject>Methanol - chemistry</subject><subject>Solvents - chemistry</subject><subject>Stability</subject><subject>Time Factors</subject><subject>Water - chemistry</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAUhoMobk5v_AHSKy-Ebkna5uNK5vALJgrqdUjTU9eRLjPpwPnrzViZN-fAex5eDg9ClwSPc0zopGqXY1qMqRRHaEiEICnJGDlGQ0wFT_Mi5wN0FsIS41wyIU7RgDBJGM2yIZq8d7psbNNtE1cnd7D6dVubvIF3P00FSbNKXqBbxGhqjVs4e45Oam0DXPR7hD4f7j9mT-n89fF5Np2npmCiSynPGDMFp6RiLOMlJcCIqXJZA5OMSyCMM1IzTcTuqZiXEkod_-aVxtxkI3S97117972B0Km2CQas1Stwm6CY4IWgmETwZg8a70LwUKu1b1rtt4pgtdOjoh5FCxX1RPiqb92ULVT_aO8jArd7YBk6_QUHQPuuMRYOXf2Q4nAxC-0VrLI_C_N1MA</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>HONGO, Toshio</creator><creator>HIKAGE, Sakari</creator><creator>SATO, Atsushige</creator><general>The Japanese Society for Dental Materials and Devices</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Stability of Benzoyl Peroxide in Methyl Alcohol</title><author>HONGO, Toshio ; HIKAGE, Sakari ; SATO, Atsushige</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-27366c5721d6637b21e61cd49fe69679e16761f6a18049649fb9eba1367da07c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetone - chemistry</topic><topic>Acetonitriles - chemistry</topic><topic>Benzoates</topic><topic>Benzoic Acid</topic><topic>Benzoyl peroxide</topic><topic>Benzoyl Peroxide - chemistry</topic><topic>Centrifugation, Density Gradient</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Composite Resins - chemistry</topic><topic>Dentistry</topic><topic>Drug Stability</topic><topic>Ethanol - chemistry</topic><topic>HPLC</topic><topic>Methanol - chemistry</topic><topic>Solvents - chemistry</topic><topic>Stability</topic><topic>Time Factors</topic><topic>Water - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>HONGO, Toshio</creatorcontrib><creatorcontrib>HIKAGE, Sakari</creatorcontrib><creatorcontrib>SATO, Atsushige</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HONGO, Toshio</au><au>HIKAGE, Sakari</au><au>SATO, Atsushige</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability of Benzoyl Peroxide in Methyl Alcohol</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>25</volume><issue>2</issue><spage>298</spage><epage>302</epage><pages>298-302</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>The purpose of this study was to clarify the stability of benzoyl peroxide (BPO) in some solvents. BPO was dissolved in acetone, acetonitrile (AcCN) , 50% acetonitrile-50% distilled water (50% AcCN) , ethyl alcohol (EtOH) , and methyl alcohol (MeOH) . Solutions containing BPO were incubated for eight days at 25°C. In MeOH, BPO rapidly decomposed into benzoic acid (BA) and methyl benzoate (MeBA) time-dependently, whereas BPO in acetone, AcCN, and 50% AcCN was relatively stable. Although BPO in EtOH was slightly stable within the first 24 hours, it decomposed time-dependently such that BA and EtBA as decomposition products of BPO were produced. 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| ispartof | Dental Materials Journal, 2006, Vol.25(2), pp.298-302 |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Acetone - chemistry Acetonitriles - chemistry Benzoates Benzoic Acid Benzoyl peroxide Benzoyl Peroxide - chemistry Centrifugation, Density Gradient Chromatography, High Pressure Liquid Composite Resins - chemistry Dentistry Drug Stability Ethanol - chemistry HPLC Methanol - chemistry Solvents - chemistry Stability Time Factors Water - chemistry |
| title | Stability of Benzoyl Peroxide in Methyl Alcohol |
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