Selective DNA damage responses in murine Xpa −/−, Xpc −/− and Csb −/− keratinocyte cultures

Cellular DNA damage responses (DDRs) are induced by unrepaired DNA lesions and constitute a protective back-up system that prevents the expansion of damaged cells. These cellular signaling pathways trigger either growth arrest or cell death and are believed to be major components of an early anti-ca...

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Veröffentlicht in:	DNA repair 2005-11, Vol.4 (11), p.1337-1344
Hauptverfasser:	Stout, Gerdine J., Oosten, Marijke van, Acherrat, Fatima Z., Wit, Jan de, Vermeij, Wilbert P., Mullenders, Leon H.F., Gruijl, Frank R. de, Backendorf, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - radiation effects Bacteriology Biological and medical sciences Cell cycle arrest Cell cycle, cell proliferation Cell Death - radiation effects Cell Division - radiation effects Cell physiology Cells, Cultured DNA Damage - genetics DNA Damage - physiology DNA Repair - genetics DNA Repair - physiology DNA Repair Enzymes - genetics DNA Repair Enzymes - physiology DNA Repair Enzymes - radiation effects DNA Replication - radiation effects DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology DNA-Binding Proteins - radiation effects Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Global genome repair (GG-NER) Growth, nutrition, cell differenciation Keratinocytes - metabolism Keratinocytes - pathology Keratinocytes - radiation effects Mice Microbiology Molecular and cellular biology Molecular genetics Mouse keratinocytes Mutagenesis. Repair Nucleotide excision repair (NER) Poly-ADP-Ribose Binding Proteins Radiation Tolerance S Phase - genetics S Phase - radiation effects Signal Transduction - genetics Signal Transduction - radiation effects Skin Neoplasms - etiology Skin Neoplasms - genetics Skin Neoplasms - pathology Transcription-coupled repair (TC-NER) Ultraviolet light Ultraviolet Rays Xeroderma Pigmentosum Group A Protein - genetics Xeroderma Pigmentosum Group A Protein - physiology Xeroderma Pigmentosum Group A Protein - radiation effects
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