DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF

The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA damage and oncogene activation. It is unclear, however, how ARF initiates its involvement in the p53/mdm2 pathway, as p53 and m...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-11, Vol.65 (21), p.9834-9842
Hauptverfasser:	LEE, Casey, SMITH, Brian A, BANDYOPADHYAY, Keya, GJERSET, Ruth A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Cell Line, Tumor Cell Nucleolus - metabolism Cell physiology Cell Survival - physiology Cell Survival - radiation effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Damage - physiology Fundamental and applied biological sciences. Psychology Humans Microscopy, Fluorescence Molecular and cellular biology Molecular Sequence Data Nuclear Proteins - metabolism Nucleoplasmins Phosphoproteins - metabolism Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - metabolism Ultraviolet Rays
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