Effect of Finasteride on the Sensitivity of PSA for Detecting Prostate Cancer

Background: In the Prostate Cancer Prevention Trial (PCPT), men receiving finasteride had a 24.8% lower risk of prostate cancer than men receiving placebo but a higher risk of high-grade cancer. We examined the impact of finasteride on the sensitivity and area under the receiver operating characteri...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2006-08, Vol.98 (16), p.1128-1133
Hauptverfasser:	Thompson, Ian M., Chi, Chen, Ankerst, Donna Pauler, Goodman, Phyllis J., Tangen, Catherine M., Lippman, Scott M., Lucia, M. Scott, Parnes, Howard L., Coltman, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Area Under Curve Biological and medical sciences Biopsy Clinical outcomes Diagnostic tests Disease prevention Drug therapy Enzyme Inhibitors - pharmacology Finasteride - pharmacology Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Predictive Value of Tests Prostate cancer Prostate-Specific Antigen - blood Prostatic Hyperplasia - diagnosis Prostatic Hyperplasia - immunology Prostatic Neoplasms - diagnosis Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatitis - diagnosis Prostatitis - immunology Research Design ROC Curve Sensitivity and Specificity Tumors Tumors of the urinary system Urinary tract. Prostate gland Validation studies
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