Biological Properties of a Novel Follicle-Stimulating Hormone/Human Chorionic Gonadotropin Chimeric Gonadotropin

A chimeric recombinant human gonadotropin, termed C3, demonstrates both follitropic and lutropic bioactivities. The α-subunit construct for C3 is comprised of the recombinant wild-type human glycoprotein hormone α-subunit. The β-subunit DNA construct for C3 encodes residues 1–145 from human chorioni...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2006-09, Vol.147 (9), p.4205-4212
Hauptverfasser:	Garone, Louise M, Ammannati, Elena, Brush, Theresa S, Fischer, David J, Tos, Enrico Gillio, Luo, Jiangping, Altobello, Kimberley L, Ciampolillo, Cinzia, Ihley, Thomas M, Kurosawa, Emmi, Tiebout, Angela, McKenna, Sean
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Bioassays Biological and medical sciences Biological effects Biological properties Chorionic gonadotropin Chorionic Gonadotropin - genetics Chorionic Gonadotropin - pharmacology Chorionic Gonadotropin, beta Subunit, Human - chemistry Chorionic Gonadotropin, beta Subunit, Human - genetics Corpus Luteum - drug effects Corpus Luteum - physiology Female Follicle Stimulating Hormone - genetics Follicle Stimulating Hormone - pharmacology Follicle Stimulating Hormone, beta Subunit - chemistry Follicle Stimulating Hormone, beta Subunit - genetics Follicle-stimulating hormone Follicles Fundamental and applied biological sciences. Psychology Gametocytes Glycoproteins Gonadotropins Humans Luteinizing hormone Molecular Sequence Data Oocytes Organ Size - drug effects Ovarian Follicle - drug effects Ovarian Follicle - physiology Pituitary (anterior) Rats Receptors, FSH - metabolism Receptors, LH - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Sequence Alignment Substitutes Uterus Uterus - anatomy & histology Vertebrates: endocrinology
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