Mechanisms of action of novel skin penetration enhancers: Phospholipid versus skin lipid liposomes

Employing thermal analysis, we investigated the mechanism of action of novel enhancers and probed phospholipid (PL) versus stratum corneum lipid (SCL) liposomes as model membranes. The enhancers included octyl salicylate (OS), padimate O (PADO) and 2-(1-nonyl)-1,3-dioxolane (ND). The negative contro...

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Veröffentlicht in:	International journal of pharmaceutics 2005-11, Vol.305 (1), p.90-104
Hauptverfasser:	Maghraby, Gamal M.M. El, Campbell, Michael, Finnin, Barrie C.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobenzoic Acid - pharmacology Biological and medical sciences Ceramides - chemistry Cholesterol - chemistry Dioxolanes - pharmacology General pharmacology High sensitivity differential scanning calorimetry Liposomes - chemistry Mechanisms Medical sciences Membrane Lipids - chemistry Model membranes para-Aminobenzoates Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phospholipids - chemistry Salicylates - pharmacology Skin Absorption - drug effects Skin penetration enhancers Solubility Stratum corneum lipid liposomes Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Transition Temperature - drug effects
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