Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response
Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F 2-isoprostanes and malondialdehyd...
Gespeichert in:
| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-11, Vol.827 (1), p.139-145 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 145 |
|---|---|
| container_issue | 1 |
| container_start_page | 139 |
| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
| container_volume | 827 |
| creator | Sowell, John Conway, Heather M. Bruno, Richard S. Traber, Maret G. Frei, Balz Stevens, Jan F. |
| description | Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F
2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress. |
| doi_str_mv | 10.1016/j.jchromb.2005.05.046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68751465</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1570023205004101</els_id><sourcerecordid>68751465</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-b8366081e21ebe0cccda9b9b2663a736e8f11d19c9ae511d45bf04625dc7e1103</originalsourceid><addsrcrecordid>eNqFUF1LwzAUDaI4nf4EpU--tSZNm7ZPMoZfMPBFxbeQj1uW2TU1ycb6783YwEfhcr84517OQeiG4Ixgwu5X2UotnV3LLMe4zPZRsBN0QeqKprRiX6exLyuc4pzmE3Tp_QpjUuGKnqMJYXFbN_UF-px5ZZ0cOxFAJ0W6HLWzuzHN09720IsuET4RyWAD9MHEURq7Fu4bXGLbxO6MFsFsIfHBgfdJTIPtPVyhs1Z0Hq6PdYo-nh7f5y_p4u35dT5bpIo2eUhlTRnDNYGcgASslNKikY3MGaOiogzqlhBNGtUIKGNXlLKNMvNSqwoIwXSK7g53B2d_NuADXxuvoOtED3bjOaurkhSsjMDyAFTOeu-g5YMzUcjICeZ7Q_mKHw3le0P5PgoWebfHBxu5Bv3HOjoYAQ8HAESZWwOOe2WgV6CNAxW4tuafF79t3orA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68751465</pqid></control><display><type>article</type><title>Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Sowell, John ; Conway, Heather M. ; Bruno, Richard S. ; Traber, Maret G. ; Frei, Balz ; Stevens, Jan F.</creator><creatorcontrib>Sowell, John ; Conway, Heather M. ; Bruno, Richard S. ; Traber, Maret G. ; Frei, Balz ; Stevens, Jan F.</creatorcontrib><description>Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F
2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2005.05.046</identifier><identifier>PMID: 16023898</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>4-Hydroxy-2-nonenal ; Adolescent ; Adult ; Aldehydes - analysis ; Aldehydes - blood ; Aldehydes - chemistry ; Ascorbic acid ; Ascorbic Acid - analogs & derivatives ; Ascorbic Acid - blood ; Ascorbic Acid - metabolism ; Biomarker ; Biomarkers - blood ; Chromatography, Liquid - methods ; Humans ; Lipid peroxidation ; Mass spectrometry ; Mass Spectrometry - methods ; Oxidative stress ; Oxidative Stress - physiology ; Smoking - blood ; Vitamin C</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-11, Vol.827 (1), p.139-145</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-b8366081e21ebe0cccda9b9b2663a736e8f11d19c9ae511d45bf04625dc7e1103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1570023205004101$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16023898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sowell, John</creatorcontrib><creatorcontrib>Conway, Heather M.</creatorcontrib><creatorcontrib>Bruno, Richard S.</creatorcontrib><creatorcontrib>Traber, Maret G.</creatorcontrib><creatorcontrib>Frei, Balz</creatorcontrib><creatorcontrib>Stevens, Jan F.</creatorcontrib><title>Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F
2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress.</description><subject>4-Hydroxy-2-nonenal</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aldehydes - analysis</subject><subject>Aldehydes - blood</subject><subject>Aldehydes - chemistry</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - analogs & derivatives</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - metabolism</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Chromatography, Liquid - methods</subject><subject>Humans</subject><subject>Lipid peroxidation</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Smoking - blood</subject><subject>Vitamin C</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUF1LwzAUDaI4nf4EpU--tSZNm7ZPMoZfMPBFxbeQj1uW2TU1ycb6783YwEfhcr84517OQeiG4Ixgwu5X2UotnV3LLMe4zPZRsBN0QeqKprRiX6exLyuc4pzmE3Tp_QpjUuGKnqMJYXFbN_UF-px5ZZ0cOxFAJ0W6HLWzuzHN09720IsuET4RyWAD9MHEURq7Fu4bXGLbxO6MFsFsIfHBgfdJTIPtPVyhs1Z0Hq6PdYo-nh7f5y_p4u35dT5bpIo2eUhlTRnDNYGcgASslNKikY3MGaOiogzqlhBNGtUIKGNXlLKNMvNSqwoIwXSK7g53B2d_NuADXxuvoOtED3bjOaurkhSsjMDyAFTOeu-g5YMzUcjICeZ7Q_mKHw3le0P5PgoWebfHBxu5Bv3HOjoYAQ8HAESZWwOOe2WgV6CNAxW4tuafF79t3orA</recordid><startdate>20051115</startdate><enddate>20051115</enddate><creator>Sowell, John</creator><creator>Conway, Heather M.</creator><creator>Bruno, Richard S.</creator><creator>Traber, Maret G.</creator><creator>Frei, Balz</creator><creator>Stevens, Jan F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051115</creationdate><title>Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response</title><author>Sowell, John ; Conway, Heather M. ; Bruno, Richard S. ; Traber, Maret G. ; Frei, Balz ; Stevens, Jan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-b8366081e21ebe0cccda9b9b2663a736e8f11d19c9ae511d45bf04625dc7e1103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>4-Hydroxy-2-nonenal</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aldehydes - analysis</topic><topic>Aldehydes - blood</topic><topic>Aldehydes - chemistry</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - analogs & derivatives</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - metabolism</topic><topic>Biomarker</topic><topic>Biomarkers - blood</topic><topic>Chromatography, Liquid - methods</topic><topic>Humans</topic><topic>Lipid peroxidation</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Smoking - blood</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sowell, John</creatorcontrib><creatorcontrib>Conway, Heather M.</creatorcontrib><creatorcontrib>Bruno, Richard S.</creatorcontrib><creatorcontrib>Traber, Maret G.</creatorcontrib><creatorcontrib>Frei, Balz</creatorcontrib><creatorcontrib>Stevens, Jan F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sowell, John</au><au>Conway, Heather M.</au><au>Bruno, Richard S.</au><au>Traber, Maret G.</au><au>Frei, Balz</au><au>Stevens, Jan F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response</atitle><jtitle>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2005-11-15</date><risdate>2005</risdate><volume>827</volume><issue>1</issue><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F
2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16023898</pmid><doi>10.1016/j.jchromb.2005.05.046</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1570-0232 |
| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-11, Vol.827 (1), p.139-145 |
| issn | 1570-0232 1873-376X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68751465 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 4-Hydroxy-2-nonenal Adolescent Adult Aldehydes - analysis Aldehydes - blood Aldehydes - chemistry Ascorbic acid Ascorbic Acid - analogs & derivatives Ascorbic Acid - blood Ascorbic Acid - metabolism Biomarker Biomarkers - blood Chromatography, Liquid - methods Humans Lipid peroxidation Mass spectrometry Mass Spectrometry - methods Oxidative stress Oxidative Stress - physiology Smoking - blood Vitamin C |
| title | Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A03%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ascorbylated%204-hydroxy-2-nonenal%20as%20a%20potential%20biomarker%20of%20oxidative%20stress%20response&rft.jtitle=Journal%20of%20chromatography.%20B,%20Analytical%20technologies%20in%20the%20biomedical%20and%20life%20sciences&rft.au=Sowell,%20John&rft.date=2005-11-15&rft.volume=827&rft.issue=1&rft.spage=139&rft.epage=145&rft.pages=139-145&rft.issn=1570-0232&rft.eissn=1873-376X&rft_id=info:doi/10.1016/j.jchromb.2005.05.046&rft_dat=%3Cproquest_cross%3E68751465%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68751465&rft_id=info:pmid/16023898&rft_els_id=S1570023205004101&rfr_iscdi=true |