Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma

Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic growth factor that is a primary stimulant of the development and maintenance of a vascular network in the vascularization of solid tumors. It has been reported that a blockade of VEGF-mediated angiogenesis is a powerful method...

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Veröffentlicht in:	Molecular therapy 2006-09, Vol.14 (3), p.343-350
Hauptverfasser:	Kim, Won Jong, Christensen, Lane V, Jo, Seongbong, Yockman, James W, Jeong, Ji Hoon, Kim, Yong-Hee, Kim, Sung Wan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - pathology Adenocarcinoma - therapy Angiogenesis Animals Cancer Cholesterol Cholesterol - analogs & derivatives Cholesterol - chemistry Colonic Neoplasms - blood supply Colonic Neoplasms - pathology Colonic Neoplasms - therapy Cytotoxicity Efficiency Gene therapy Genetic Therapy - methods Lipids Neovascularization, Pathologic - pathology Neovascularization, Pathologic - therapy Oligopeptides - chemistry Peptides Plasmids - chemistry Ratios RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry Transfection Tumor Cells, Cultured Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - genetics Vehicles
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