Volatile anesthetics constrict pulmonary artery in rabbit lung perfusion model
Volatile anesthetics are generally considered to possess a vasodilator action. Some of their actions on pulmonary vessels, however, are not clearly understood. We examined the effects of various volatile anesthetics on pulmonary vessels using an in situ rabbit isolated-lung perfusion model. We prepa...
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| Veröffentlicht in: | Journal of anesthesia 2005-11, Vol.19 (4), p.343-346 |
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| container_issue | 4 |
| container_start_page | 343 |
| container_title | Journal of anesthesia |
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| creator | Takemura, Mitsuhiro Shiokawa, Yasuhiro Okamoto, Shinji Uno, Hiroshi Futagawa, Koichi Koga, Yoshihisa |
| description | Volatile anesthetics are generally considered to possess a vasodilator action. Some of their actions on pulmonary vessels, however, are not clearly understood. We examined the effects of various volatile anesthetics on pulmonary vessels using an in situ rabbit isolated-lung perfusion model. We prepared a rabbit constant-flow lung-perfusion model by sending blood to the pulmonary artery and removing blood from the left atrium, and observed the changes in pulmonary arterial perfusion pressure caused by inhalation of 0.5, 1, 2, and 3 minimum alveolar concentration (MAC) volatile anesthetics: halothane, enflurane, isoflurane, and sevoflurane, in random order. These volatile anesthetics increased pulmonary arterial perfusion pressure in a dose-dependent manner and caused the pulmonary arteries to constrict. In particular, halothane at all concentrations induced significantly greater pulmonary vasoconstriction than the other volatile anesthetics. Therefore, it is suggested that volatile inhalation anesthetics induce the pulmonary arteries to constrict, and halothane exhibits the most potent pulmonary vasoconstrictor effect among the volatile anesthetics tested. |
| doi_str_mv | 10.1007/s00540-005-0343-z |
| format | Article |
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Some of their actions on pulmonary vessels, however, are not clearly understood. We examined the effects of various volatile anesthetics on pulmonary vessels using an in situ rabbit isolated-lung perfusion model. We prepared a rabbit constant-flow lung-perfusion model by sending blood to the pulmonary artery and removing blood from the left atrium, and observed the changes in pulmonary arterial perfusion pressure caused by inhalation of 0.5, 1, 2, and 3 minimum alveolar concentration (MAC) volatile anesthetics: halothane, enflurane, isoflurane, and sevoflurane, in random order. These volatile anesthetics increased pulmonary arterial perfusion pressure in a dose-dependent manner and caused the pulmonary arteries to constrict. In particular, halothane at all concentrations induced significantly greater pulmonary vasoconstriction than the other volatile anesthetics. Therefore, it is suggested that volatile inhalation anesthetics induce the pulmonary arteries to constrict, and halothane exhibits the most potent pulmonary vasoconstrictor effect among the volatile anesthetics tested.</description><identifier>ISSN: 0913-8668</identifier><identifier>EISSN: 1438-8359</identifier><identifier>DOI: 10.1007/s00540-005-0343-z</identifier><identifier>PMID: 16261478</identifier><language>eng</language><publisher>Japan: Springer</publisher><subject>Anesthetics, Inhalation - pharmacology ; Animals ; Care and treatment ; Causes of ; Complications and side effects ; Dosage and administration ; Dose-Response Relationship, Drug ; Enflurane - pharmacology ; General anesthetics ; Halothane - pharmacology ; Isoflurane - pharmacology ; Lung diseases ; Male ; Models, Animal ; Perfusion ; Pulmonary Artery - drug effects ; Pulmonary Circulation - drug effects ; Rabbits ; Transducers, Pressure ; Vasoconstriction - drug effects</subject><ispartof>Journal of anesthesia, 2005-11, Vol.19 (4), p.343-346</ispartof><rights>COPYRIGHT 2005 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-3d4384b08ab892437fae8b7807b5c2b4c7b04cf8d1eb41a075df181bdd20bb7e3</citedby><cites>FETCH-LOGICAL-c295t-3d4384b08ab892437fae8b7807b5c2b4c7b04cf8d1eb41a075df181bdd20bb7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16261478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takemura, Mitsuhiro</creatorcontrib><creatorcontrib>Shiokawa, Yasuhiro</creatorcontrib><creatorcontrib>Okamoto, Shinji</creatorcontrib><creatorcontrib>Uno, Hiroshi</creatorcontrib><creatorcontrib>Futagawa, Koichi</creatorcontrib><creatorcontrib>Koga, Yoshihisa</creatorcontrib><title>Volatile anesthetics constrict pulmonary artery in rabbit lung perfusion model</title><title>Journal of anesthesia</title><addtitle>J Anesth</addtitle><description>Volatile anesthetics are generally considered to possess a vasodilator action. Some of their actions on pulmonary vessels, however, are not clearly understood. We examined the effects of various volatile anesthetics on pulmonary vessels using an in situ rabbit isolated-lung perfusion model. We prepared a rabbit constant-flow lung-perfusion model by sending blood to the pulmonary artery and removing blood from the left atrium, and observed the changes in pulmonary arterial perfusion pressure caused by inhalation of 0.5, 1, 2, and 3 minimum alveolar concentration (MAC) volatile anesthetics: halothane, enflurane, isoflurane, and sevoflurane, in random order. These volatile anesthetics increased pulmonary arterial perfusion pressure in a dose-dependent manner and caused the pulmonary arteries to constrict. In particular, halothane at all concentrations induced significantly greater pulmonary vasoconstriction than the other volatile anesthetics. Therefore, it is suggested that volatile inhalation anesthetics induce the pulmonary arteries to constrict, and halothane exhibits the most potent pulmonary vasoconstrictor effect among the volatile anesthetics tested.</description><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Animals</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Complications and side effects</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enflurane - pharmacology</subject><subject>General anesthetics</subject><subject>Halothane - pharmacology</subject><subject>Isoflurane - pharmacology</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Perfusion</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Rabbits</subject><subject>Transducers, Pressure</subject><subject>Vasoconstriction - drug effects</subject><issn>0913-8668</issn><issn>1438-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD9PwzAUxC0EoqXwAVhQJCS2wHPsxO5YIf5JFSzAatmOU4ycuNjOQD89rlKJ5W753dO9Q-gSwy0GYHcRoKZQZi2BUFLujtAcU8JLTurlMZrDEpOSNw2fobMYvwGgwZicohluqgZTxufo9dM7mawzhRxMTF8mWR0L7YeYgtWp2I6u94MMv4UMyWSzQxGkUjYVbhw2xdaEbozWD0XvW-PO0UknXTQXB1-gj8eH9_vncv329HK_Wpe6WtapJG1uSRVwqfiyooR10nDFODBV60pRzRRQ3fEWG0WxBFa3HeZYtW0FSjFDFuhmursN_mfMxUVvozbO5S_8GEXDGeWYNBm8nsCNdEbYofMpSL2HxQrXFckgVJnCE6WDjzGYTmyD7fPXAoPYTy2mqUVWsZ9a7HLm6lBhVL1p_xOHbckfhTh6dQ</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Takemura, Mitsuhiro</creator><creator>Shiokawa, Yasuhiro</creator><creator>Okamoto, Shinji</creator><creator>Uno, Hiroshi</creator><creator>Futagawa, Koichi</creator><creator>Koga, Yoshihisa</creator><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Volatile anesthetics constrict pulmonary artery in rabbit lung perfusion model</title><author>Takemura, Mitsuhiro ; Shiokawa, Yasuhiro ; Okamoto, Shinji ; Uno, Hiroshi ; Futagawa, Koichi ; Koga, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c295t-3d4384b08ab892437fae8b7807b5c2b4c7b04cf8d1eb41a075df181bdd20bb7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Animals</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Complications and side effects</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Enflurane - pharmacology</topic><topic>General anesthetics</topic><topic>Halothane - pharmacology</topic><topic>Isoflurane - pharmacology</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Perfusion</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Rabbits</topic><topic>Transducers, Pressure</topic><topic>Vasoconstriction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takemura, Mitsuhiro</creatorcontrib><creatorcontrib>Shiokawa, Yasuhiro</creatorcontrib><creatorcontrib>Okamoto, Shinji</creatorcontrib><creatorcontrib>Uno, Hiroshi</creatorcontrib><creatorcontrib>Futagawa, Koichi</creatorcontrib><creatorcontrib>Koga, Yoshihisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takemura, Mitsuhiro</au><au>Shiokawa, Yasuhiro</au><au>Okamoto, Shinji</au><au>Uno, Hiroshi</au><au>Futagawa, Koichi</au><au>Koga, Yoshihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volatile anesthetics constrict pulmonary artery in rabbit lung perfusion model</atitle><jtitle>Journal of anesthesia</jtitle><addtitle>J Anesth</addtitle><date>2005-11</date><risdate>2005</risdate><volume>19</volume><issue>4</issue><spage>343</spage><epage>346</epage><pages>343-346</pages><issn>0913-8668</issn><eissn>1438-8359</eissn><abstract>Volatile anesthetics are generally considered to possess a vasodilator action. Some of their actions on pulmonary vessels, however, are not clearly understood. We examined the effects of various volatile anesthetics on pulmonary vessels using an in situ rabbit isolated-lung perfusion model. We prepared a rabbit constant-flow lung-perfusion model by sending blood to the pulmonary artery and removing blood from the left atrium, and observed the changes in pulmonary arterial perfusion pressure caused by inhalation of 0.5, 1, 2, and 3 minimum alveolar concentration (MAC) volatile anesthetics: halothane, enflurane, isoflurane, and sevoflurane, in random order. These volatile anesthetics increased pulmonary arterial perfusion pressure in a dose-dependent manner and caused the pulmonary arteries to constrict. In particular, halothane at all concentrations induced significantly greater pulmonary vasoconstriction than the other volatile anesthetics. Therefore, it is suggested that volatile inhalation anesthetics induce the pulmonary arteries to constrict, and halothane exhibits the most potent pulmonary vasoconstrictor effect among the volatile anesthetics tested.</abstract><cop>Japan</cop><pub>Springer</pub><pmid>16261478</pmid><doi>10.1007/s00540-005-0343-z</doi><tpages>4</tpages></addata></record> |
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| subjects | Anesthetics, Inhalation - pharmacology Animals Care and treatment Causes of Complications and side effects Dosage and administration Dose-Response Relationship, Drug Enflurane - pharmacology General anesthetics Halothane - pharmacology Isoflurane - pharmacology Lung diseases Male Models, Animal Perfusion Pulmonary Artery - drug effects Pulmonary Circulation - drug effects Rabbits Transducers, Pressure Vasoconstriction - drug effects |
| title | Volatile anesthetics constrict pulmonary artery in rabbit lung perfusion model |
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