Human African trypanosomiasis: connecting parasite and host genetics
In West and Central Africa, the protozoan parasite Trypanosoma brucei ( T. b.) gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both fo...
Gespeichert in:
| Veröffentlicht in: | Trends in parasitology 2006-09, Vol.22 (9), p.405-409 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 409 |
|---|---|
| container_issue | 9 |
| container_start_page | 405 |
| container_title | Trends in parasitology |
| container_volume | 22 |
| creator | Garcia, André Courtin, David Solano, Philippe Koffi, Mathurin Jamonneau, Vincent |
| description | In West and Central Africa, the protozoan parasite
Trypanosoma brucei (
T. b.)
gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas
T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence. |
| doi_str_mv | 10.1016/j.pt.2006.06.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68747587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1471492206001723</els_id><sourcerecordid>68747587</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-1853b3adb8c154de505fcc80e30fd3c680583ebbf7a2ec7e6931db1be228ffed3</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVpaJJt7z0VX5rbbjSSZcm5hTRfsJBLehayNEq1rGVX0hby72OzhpxKYOAdhmeG4SHkO9ANUGgud5uxbBilzWYugE_kDGoJa0Gp_Lz0dcvYKTnPeUcpCCnbL-QUGsUlq8UZ-fVw6E2srn0KdsqSXkcThzz0weSQryo7xIi2hPhSjSZNs4KVia76M-RSvWDEEmz-Sk682Wf8tuSK_L67fb55WG-f7h9vrrdrW9O2rEEJ3nHjOmVB1A4FFd5aRZFT77htFBWKY9d5aRhaiU3LwXXQIWPKe3R8RS6Od8c0_D1gLroP2eJ-byIOh6wbJWsplPwQhJZzYKyeQHoEbRpyTuj1mEJv0qsGqmfFeqfHomfFei6AaeXHcvvQ9ejeFxanE_BzAUy2Zu-TiTbkd05R3oh25q6OHE7K_gVMOtuA0aILaVKu3RD-_8UbPN2ZEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19331224</pqid></control><display><type>article</type><title>Human African trypanosomiasis: connecting parasite and host genetics</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Garcia, André ; Courtin, David ; Solano, Philippe ; Koffi, Mathurin ; Jamonneau, Vincent</creator><creatorcontrib>Garcia, André ; Courtin, David ; Solano, Philippe ; Koffi, Mathurin ; Jamonneau, Vincent</creatorcontrib><description>In West and Central Africa, the protozoan parasite
Trypanosoma brucei (
T. b.)
gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas
T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence.</description><identifier>ISSN: 1471-4922</identifier><identifier>EISSN: 1471-5007</identifier><identifier>DOI: 10.1016/j.pt.2006.06.011</identifier><identifier>PMID: 16837245</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Africa - epidemiology ; Animals ; Biological and medical sciences ; Endemic Diseases - prevention & control ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; Genetics of eukaryotes. Biological and molecular evolution ; Host-Parasite Interactions - genetics ; Humans ; Immunity, Innate - genetics ; Invertebrata ; Population genetics, reproduction patterns ; Trypanosoma brucei ; Trypanosoma brucei gambiense - genetics ; Trypanosoma brucei gambiense - isolation & purification ; Trypanosoma brucei rhodesiense - genetics ; Trypanosoma brucei rhodesiense - isolation & purification ; Trypanosomiasis, African - diagnosis ; Trypanosomiasis, African - epidemiology ; Trypanosomiasis, African - immunology ; Trypanosomiasis, African - parasitology</subject><ispartof>Trends in parasitology, 2006-09, Vol.22 (9), p.405-409</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1853b3adb8c154de505fcc80e30fd3c680583ebbf7a2ec7e6931db1be228ffed3</citedby><cites>FETCH-LOGICAL-c409t-1853b3adb8c154de505fcc80e30fd3c680583ebbf7a2ec7e6931db1be228ffed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pt.2006.06.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18036595$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16837245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, André</creatorcontrib><creatorcontrib>Courtin, David</creatorcontrib><creatorcontrib>Solano, Philippe</creatorcontrib><creatorcontrib>Koffi, Mathurin</creatorcontrib><creatorcontrib>Jamonneau, Vincent</creatorcontrib><title>Human African trypanosomiasis: connecting parasite and host genetics</title><title>Trends in parasitology</title><addtitle>Trends Parasitol</addtitle><description>In West and Central Africa, the protozoan parasite
Trypanosoma brucei (
T. b.)
gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas
T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence.</description><subject>Africa - epidemiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Endemic Diseases - prevention & control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Variation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Host-Parasite Interactions - genetics</subject><subject>Humans</subject><subject>Immunity, Innate - genetics</subject><subject>Invertebrata</subject><subject>Population genetics, reproduction patterns</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma brucei gambiense - genetics</subject><subject>Trypanosoma brucei gambiense - isolation & purification</subject><subject>Trypanosoma brucei rhodesiense - genetics</subject><subject>Trypanosoma brucei rhodesiense - isolation & purification</subject><subject>Trypanosomiasis, African - diagnosis</subject><subject>Trypanosomiasis, African - epidemiology</subject><subject>Trypanosomiasis, African - immunology</subject><subject>Trypanosomiasis, African - parasitology</subject><issn>1471-4922</issn><issn>1471-5007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaJJt7z0VX5rbbjSSZcm5hTRfsJBLehayNEq1rGVX0hby72OzhpxKYOAdhmeG4SHkO9ANUGgud5uxbBilzWYugE_kDGoJa0Gp_Lz0dcvYKTnPeUcpCCnbL-QUGsUlq8UZ-fVw6E2srn0KdsqSXkcThzz0weSQryo7xIi2hPhSjSZNs4KVia76M-RSvWDEEmz-Sk682Wf8tuSK_L67fb55WG-f7h9vrrdrW9O2rEEJ3nHjOmVB1A4FFd5aRZFT77htFBWKY9d5aRhaiU3LwXXQIWPKe3R8RS6Od8c0_D1gLroP2eJ-byIOh6wbJWsplPwQhJZzYKyeQHoEbRpyTuj1mEJv0qsGqmfFeqfHomfFei6AaeXHcvvQ9ejeFxanE_BzAUy2Zu-TiTbkd05R3oh25q6OHE7K_gVMOtuA0aILaVKu3RD-_8UbPN2ZEQ</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Garcia, André</creator><creator>Courtin, David</creator><creator>Solano, Philippe</creator><creator>Koffi, Mathurin</creator><creator>Jamonneau, Vincent</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Human African trypanosomiasis: connecting parasite and host genetics</title><author>Garcia, André ; Courtin, David ; Solano, Philippe ; Koffi, Mathurin ; Jamonneau, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1853b3adb8c154de505fcc80e30fd3c680583ebbf7a2ec7e6931db1be228ffed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Africa - epidemiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Endemic Diseases - prevention & control</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Variation</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Host-Parasite Interactions - genetics</topic><topic>Humans</topic><topic>Immunity, Innate - genetics</topic><topic>Invertebrata</topic><topic>Population genetics, reproduction patterns</topic><topic>Trypanosoma brucei</topic><topic>Trypanosoma brucei gambiense - genetics</topic><topic>Trypanosoma brucei gambiense - isolation & purification</topic><topic>Trypanosoma brucei rhodesiense - genetics</topic><topic>Trypanosoma brucei rhodesiense - isolation & purification</topic><topic>Trypanosomiasis, African - diagnosis</topic><topic>Trypanosomiasis, African - epidemiology</topic><topic>Trypanosomiasis, African - immunology</topic><topic>Trypanosomiasis, African - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, André</creatorcontrib><creatorcontrib>Courtin, David</creatorcontrib><creatorcontrib>Solano, Philippe</creatorcontrib><creatorcontrib>Koffi, Mathurin</creatorcontrib><creatorcontrib>Jamonneau, Vincent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, André</au><au>Courtin, David</au><au>Solano, Philippe</au><au>Koffi, Mathurin</au><au>Jamonneau, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human African trypanosomiasis: connecting parasite and host genetics</atitle><jtitle>Trends in parasitology</jtitle><addtitle>Trends Parasitol</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>22</volume><issue>9</issue><spage>405</spage><epage>409</epage><pages>405-409</pages><issn>1471-4922</issn><eissn>1471-5007</eissn><abstract>In West and Central Africa, the protozoan parasite
Trypanosoma brucei (
T. b.)
gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas
T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16837245</pmid><doi>10.1016/j.pt.2006.06.011</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-4922 |
| ispartof | Trends in parasitology, 2006-09, Vol.22 (9), p.405-409 |
| issn | 1471-4922 1471-5007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68747587 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Africa - epidemiology Animals Biological and medical sciences Endemic Diseases - prevention & control Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Host-Parasite Interactions - genetics Humans Immunity, Innate - genetics Invertebrata Population genetics, reproduction patterns Trypanosoma brucei Trypanosoma brucei gambiense - genetics Trypanosoma brucei gambiense - isolation & purification Trypanosoma brucei rhodesiense - genetics Trypanosoma brucei rhodesiense - isolation & purification Trypanosomiasis, African - diagnosis Trypanosomiasis, African - epidemiology Trypanosomiasis, African - immunology Trypanosomiasis, African - parasitology |
| title | Human African trypanosomiasis: connecting parasite and host genetics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A45%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20African%20trypanosomiasis:%20connecting%20parasite%20and%20host%20genetics&rft.jtitle=Trends%20in%20parasitology&rft.au=Garcia,%20Andr%C3%A9&rft.date=2006-09-01&rft.volume=22&rft.issue=9&rft.spage=405&rft.epage=409&rft.pages=405-409&rft.issn=1471-4922&rft.eissn=1471-5007&rft_id=info:doi/10.1016/j.pt.2006.06.011&rft_dat=%3Cproquest_cross%3E68747587%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19331224&rft_id=info:pmid/16837245&rft_els_id=S1471492206001723&rfr_iscdi=true |