Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits

A high-performance liquid chromatography (HPLC) method to determine malondialdehyde (MDA) as the 2,4-dinitrophenylhydrazine (DNPH) derivative was applied to biological samples (serum and liver homogenates). Since MDA is considered a presumptive biomarker for lipid peroxidation in live organisms, a m...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-11, Vol.827 (1), p.76-82
Hauptverfasser:	Mateos, Raquel, Lecumberri, Elena, Ramos, Sonia, Goya, Luis, Bravo, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - administration & dosage Biomarkers - analysis Chromatography, High Pressure Liquid - methods Diet Disease Models, Animal Fruit - chemistry Hypercholesterolemia - blood Liver - chemistry Male Malondialdehyde - analysis Malondialdehyde - blood Oxidative Stress - physiology Phenols - administration & dosage Rats Rats, Wistar
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