Serum 1H-nuclear magnetic spectroscopy followed by principal component analysis and hierarchical cluster analysis to demonstrate effects of statins on hyperlipidemic patients

Use of statins for prevention of coronary heart disease is based on the decrease of serum cholesterol and LDL cholesterol. To better investigate the changes in lipid profile after statin treatment, we propose here to use an analysis of serum by proton nuclear magnetic resonance (NMR) spectroscopy as...

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Veröffentlicht in:	NMR in biomedicine 2005-11, Vol.18 (7), p.421-429
Hauptverfasser:	Moyec, Laurence Le, Valensi, Paul, Charniot, Jean-Christophe, Hantz, Edith, Albertini, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atorvastatin Calcium Cholesterol - blood Cluster Analysis Coronary Disease - prevention & control Heptanoic Acids - therapeutic use Humans Hyperlipidemias - blood Hyperlipidemias - drug therapy Hypolipidemic Agents - therapeutic use Lipoproteins, HDL - blood Lipoproteins, LDL - blood Male Middle Aged Multivariate Analysis Nuclear Magnetic Resonance, Biomolecular Principal Component Analysis Pyrroles - therapeutic use Reproducibility of Results serum lipids Simvastatin - therapeutic use statin
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