Serum uric acid levels and the risk of Parkinson disease
In a prospective population‐based cohort study among 4,695 participants aged 55 years and older, with repeated in‐person examination and on average 9.4 years of follow‐up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adju...
Gespeichert in:
| Veröffentlicht in: | Annals of neurology 2005-11, Vol.58 (5), p.797-800 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 800 |
|---|---|
| container_issue | 5 |
| container_start_page | 797 |
| container_title | Annals of neurology |
| container_volume | 58 |
| creator | de Lau, Lonneke M. L. Koudstaal, Peter J. Hofman, Albert Breteler, Monique M. B. |
| description | In a prospective population‐based cohort study among 4,695 participants aged 55 years and older, with repeated in‐person examination and on average 9.4 years of follow‐up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51–0.98]), with evidence for a dose–effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid. Ann Neurol 2005;58:797–800 |
| doi_str_mv | 10.1002/ana.20663 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68745543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68745543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4573-829104f7ae84e22879f181217aa8349abf7454ee4cd6cee3864e16a0c3cf110a3</originalsourceid><addsrcrecordid>eNp1kLtOxDAQRS0EguVR8APIDUgUAU_sOE654rGAeEkLorQGZyIM2QTsDY-_J7ALVFTTnHvv6DC2CWIPhEj3scG9VGgtF9gAMgmJSVWxyAZCapVkINUKW43xUQhRaBDLbAV0qoTM9ICZMYVuwrvgHUfnS17TK9WRY1Py6QPx4OMTbyt-jeHJN7FteOkjYaR1tlRhHWljftfY7fHRzcFJcn41Oj0YnidOZbnsPylAqCpHMorS1ORFBQZSyBGNVAXeV7nKFJFypXZE0mhFoFE46SoAgXKN7cx6n0P70lGc2omPjuoaG2q7aLXpCzIle3B3BrrQxhioss_BTzB8WBD2S5PtNdlvTT27NS_t7idU_pFzLz2wPQcwOqyrgI3z8Y_LpREgTc_tz7g3X9PH_4t2eDn8mU5mCR-n9P6b6PVancs8s3eXIwvj0cXZ4YW2Y_kJroqLRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68745543</pqid></control><display><type>article</type><title>Serum uric acid levels and the risk of Parkinson disease</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>de Lau, Lonneke M. L. ; Koudstaal, Peter J. ; Hofman, Albert ; Breteler, Monique M. B.</creator><creatorcontrib>de Lau, Lonneke M. L. ; Koudstaal, Peter J. ; Hofman, Albert ; Breteler, Monique M. B.</creatorcontrib><description>In a prospective population‐based cohort study among 4,695 participants aged 55 years and older, with repeated in‐person examination and on average 9.4 years of follow‐up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51–0.98]), with evidence for a dose–effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid. Ann Neurol 2005;58:797–800</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.20663</identifier><identifier>PMID: 16240356</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Community Health Planning ; Confidence Intervals ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Follow-Up Studies ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Parkinson Disease - blood ; Parkinson Disease - epidemiology ; Proportional Hazards Models ; Prospective Studies ; Retrospective Studies ; Risk ; Uric Acid - blood</subject><ispartof>Annals of neurology, 2005-11, Vol.58 (5), p.797-800</ispartof><rights>Copyright © 2005 American Neurological Association</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4573-829104f7ae84e22879f181217aa8349abf7454ee4cd6cee3864e16a0c3cf110a3</citedby><cites>FETCH-LOGICAL-c4573-829104f7ae84e22879f181217aa8349abf7454ee4cd6cee3864e16a0c3cf110a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.20663$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.20663$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17380138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16240356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lau, Lonneke M. L.</creatorcontrib><creatorcontrib>Koudstaal, Peter J.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><title>Serum uric acid levels and the risk of Parkinson disease</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>In a prospective population‐based cohort study among 4,695 participants aged 55 years and older, with repeated in‐person examination and on average 9.4 years of follow‐up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51–0.98]), with evidence for a dose–effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid. Ann Neurol 2005;58:797–800</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Community Health Planning</subject><subject>Confidence Intervals</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Uric Acid - blood</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOxDAQRS0EguVR8APIDUgUAU_sOE654rGAeEkLorQGZyIM2QTsDY-_J7ALVFTTnHvv6DC2CWIPhEj3scG9VGgtF9gAMgmJSVWxyAZCapVkINUKW43xUQhRaBDLbAV0qoTM9ICZMYVuwrvgHUfnS17TK9WRY1Py6QPx4OMTbyt-jeHJN7FteOkjYaR1tlRhHWljftfY7fHRzcFJcn41Oj0YnidOZbnsPylAqCpHMorS1ORFBQZSyBGNVAXeV7nKFJFypXZE0mhFoFE46SoAgXKN7cx6n0P70lGc2omPjuoaG2q7aLXpCzIle3B3BrrQxhioss_BTzB8WBD2S5PtNdlvTT27NS_t7idU_pFzLz2wPQcwOqyrgI3z8Y_LpREgTc_tz7g3X9PH_4t2eDn8mU5mCR-n9P6b6PVancs8s3eXIwvj0cXZ4YW2Y_kJroqLRQ</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>de Lau, Lonneke M. L.</creator><creator>Koudstaal, Peter J.</creator><creator>Hofman, Albert</creator><creator>Breteler, Monique M. B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Serum uric acid levels and the risk of Parkinson disease</title><author>de Lau, Lonneke M. L. ; Koudstaal, Peter J. ; Hofman, Albert ; Breteler, Monique M. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4573-829104f7ae84e22879f181217aa8349abf7454ee4cd6cee3864e16a0c3cf110a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Community Health Planning</topic><topic>Confidence Intervals</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Lau, Lonneke M. L.</creatorcontrib><creatorcontrib>Koudstaal, Peter J.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Breteler, Monique M. B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Lau, Lonneke M. L.</au><au>Koudstaal, Peter J.</au><au>Hofman, Albert</au><au>Breteler, Monique M. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum uric acid levels and the risk of Parkinson disease</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2005-11</date><risdate>2005</risdate><volume>58</volume><issue>5</issue><spage>797</spage><epage>800</epage><pages>797-800</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>In a prospective population‐based cohort study among 4,695 participants aged 55 years and older, with repeated in‐person examination and on average 9.4 years of follow‐up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51–0.98]), with evidence for a dose–effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid. Ann Neurol 2005;58:797–800</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16240356</pmid><doi>10.1002/ana.20663</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 2005-11, Vol.58 (5), p.797-800 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68745543 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Biological and medical sciences Community Health Planning Confidence Intervals Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurology Parkinson Disease - blood Parkinson Disease - epidemiology Proportional Hazards Models Prospective Studies Retrospective Studies Risk Uric Acid - blood |
| title | Serum uric acid levels and the risk of Parkinson disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A10%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20uric%20acid%20levels%20and%20the%20risk%20of%20Parkinson%20disease&rft.jtitle=Annals%20of%20neurology&rft.au=de%20Lau,%20Lonneke%20M.%20L.&rft.date=2005-11&rft.volume=58&rft.issue=5&rft.spage=797&rft.epage=800&rft.pages=797-800&rft.issn=0364-5134&rft.eissn=1531-8249&rft.coden=ANNED3&rft_id=info:doi/10.1002/ana.20663&rft_dat=%3Cproquest_cross%3E68745543%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68745543&rft_id=info:pmid/16240356&rfr_iscdi=true |