Implementation of a 20-nm pore-size filter in the plasma-derived Factor VIII manufacturing process

Background and Objectives  Virus inactivation and removal are important prerequisites to ensure the safety of plasma derivatives. For virus inactivation and removal in our coagulation factor VIII (FVIII) product, CROSS EIGHT M®, the production process consists of solvent–detergent (S/D) treatment, t...

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Veröffentlicht in:	Vox sanguinis 2006-08, Vol.91 (2), p.119-125
Hauptverfasser:	Furuya, Kenji, Murai, Katsushi, Yokoyama, Takeshi, Maeno, Hideki, Takeda, Yoshio, Murozuka, Takashi, Wakisaka, Akemi, Tanifuji, Masaaki, Tomono, Tsugikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	20-nm pore-size filter factor VIII Factor VIII - chemistry Factor VIII - isolation & purification Filtration - instrumentation Filtration - methods Humans Permeability small non-enveloped viruses Virion - isolation & purification Virus Diseases - prevention & control Virus Inactivation Viruses - isolation & purification
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