Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1

Long‐term depression (LTD) is one of the paradigms used in vivo or ex vivo for studying memory formation. In order to identify genes with potential relevance for memory formation we used mouse organotypic hippocampal slice cultures in which chemical LTD was induced by applications of 3,5‐dihydroxyph...

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Veröffentlicht in:	The European journal of neuroscience 2006-07, Vol.24 (2), p.555-563
Hauptverfasser:	Lindecke, Antje, Korte, Martin, Zagrebelsky, Marta, Horejschi, Volker, Elvers, Margitta, Widera, Darius, Prüllage, Maria, Pfeiffer, Julia, Kaltschmidt, Barbara, Kaltschmidt, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics c-fos C57Bl/6 mouse egr1 ets-Domain Protein Elk-1 - genetics Excitatory Amino Acid Agonists - pharmacology Gene Expression Regulation - genetics Genes, Immediate-Early - genetics Glycine - analogs & derivatives Glycine - pharmacology Hippocampus - metabolism junB Long-Term Synaptic Depression - genetics Mice Mice, Inbred C57BL nr4a1 Organ Culture Techniques organotypic Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Resorcinols - pharmacology Serum Response Factor - genetics Transcriptional Activation - genetics
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