Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients
In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients....
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2005-11, Vol.36 (10), p.885-889 |
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| creator | ABDELKEFI, A BEN ROMDHANE, N LADEB, F BEN ABDELADHIM, A KRIAA, A CHELLI, M TORJMAN, L LADEB, S BEN OTHMAN, T LAKHAL, A GUERMAZI, S BEN HASSEN, A |
| description | In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or |
| doi_str_mv | 10.1038/sj.bmt.1705156 |
| format | Article |
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We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or <24 h after, catheter removal, and in case of clinical signs of thrombosis. A total of 171 patients were included during the 28-month study period. Five (2.9%) and three (1.7%) patients had evidence of protein C and protein S deficiency, respectively. Only one patient had an antithrombin deficiency (0.6%). In total, 10 patients (5.8%) were heterozygous for the factor V Leiden mutation, and one patient had heterozygous prothrombin G20210A mutation (0.6%). We observed a CVC-related thrombosis in 13 patients (7.6%). Thrombosis was diagnosed in four out of 20 patients (20%) with a inherited prothrombotic abnormality compared to nine of 151 patients (6%) who did not have a thrombophilic marker (relative risk 3.3 CI 95% 1.1-9.9). Our results suggest that inherited prothrombotic abnormalities contribute substantially to CVC-related thrombosis in HSCT recipients. In view of physicians' reluctance to prescribe prophylactic anticoagulant treatment in these patients, a priori determination of inherited prothrombotic abnormalities may form a basis to guide these treatment decisions.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/sj.bmt.1705156</identifier><identifier>PMID: 16151418</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Abnormalities ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antithrombin ; Biological and medical sciences ; Blood clot ; Blood coagulation ; Blood Coagulation Factors - genetics ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; Catheterization - adverse effects ; Catheterization, Central Venous - adverse effects ; Catheters ; Coagulation factors ; Complications and side effects ; Diagnosis ; Emergency and intensive care: techniques, logistics ; Factor V ; Family Health ; Female ; Genetic Predisposition to Disease ; Health aspects ; Health services ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic stem cells ; Humans ; Intensive care medicine ; Male ; Markers ; Medical instruments ; Medical sciences ; Middle Aged ; Mutation ; Organ transplant recipients ; Patients ; Physicians ; Polyurethane ; Polyurethane resins ; Prevalence ; Prevention ; Prospective Studies ; Protein C ; Protein deficiency ; Protein S ; Proteins ; Prothrombin ; Prothrombin gene ; Risk factors ; Stem cell transplantation ; Stem cells ; Thromboembolism ; Thrombophilia - complications ; Thrombophilia - diagnosis ; Thrombophilia - genetics ; Thrombosis ; Thrombosis - etiology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplants ; Transplants & implants</subject><ispartof>Bone marrow transplantation (Basingstoke), 2005-11, Vol.36 (10), p.885-889</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-8f7f3595dfbc13102812ffc76d3b00ee61c749d755593306878849b61422d34b3</citedby><cites>FETCH-LOGICAL-c516t-8f7f3595dfbc13102812ffc76d3b00ee61c749d755593306878849b61422d34b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17224702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16151418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ABDELKEFI, A</creatorcontrib><creatorcontrib>BEN ROMDHANE, N</creatorcontrib><creatorcontrib>LADEB, F</creatorcontrib><creatorcontrib>BEN ABDELADHIM, A</creatorcontrib><creatorcontrib>KRIAA, A</creatorcontrib><creatorcontrib>CHELLI, M</creatorcontrib><creatorcontrib>TORJMAN, L</creatorcontrib><creatorcontrib>LADEB, S</creatorcontrib><creatorcontrib>BEN OTHMAN, T</creatorcontrib><creatorcontrib>LAKHAL, A</creatorcontrib><creatorcontrib>GUERMAZI, S</creatorcontrib><creatorcontrib>BEN HASSEN, A</creatorcontrib><title>Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><description>In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or <24 h after, catheter removal, and in case of clinical signs of thrombosis. A total of 171 patients were included during the 28-month study period. Five (2.9%) and three (1.7%) patients had evidence of protein C and protein S deficiency, respectively. Only one patient had an antithrombin deficiency (0.6%). In total, 10 patients (5.8%) were heterozygous for the factor V Leiden mutation, and one patient had heterozygous prothrombin G20210A mutation (0.6%). We observed a CVC-related thrombosis in 13 patients (7.6%). Thrombosis was diagnosed in four out of 20 patients (20%) with a inherited prothrombotic abnormality compared to nine of 151 patients (6%) who did not have a thrombophilic marker (relative risk 3.3 CI 95% 1.1-9.9). Our results suggest that inherited prothrombotic abnormalities contribute substantially to CVC-related thrombosis in HSCT recipients. In view of physicians' reluctance to prescribe prophylactic anticoagulant treatment in these patients, a priori determination of inherited prothrombotic abnormalities may form a basis to guide these treatment decisions.</description><subject>Abnormalities</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antithrombin</subject><subject>Biological and medical sciences</subject><subject>Blood clot</subject><subject>Blood coagulation</subject><subject>Blood Coagulation Factors - genetics</subject><subject>Bone marrow</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Care and treatment</subject><subject>Catheterization - adverse effects</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Catheters</subject><subject>Coagulation factors</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Emergency and intensive care: techniques, logistics</subject><subject>Factor V</subject><subject>Family Health</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Health aspects</subject><subject>Health services</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Markers</subject><subject>Medical instruments</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Organ transplant recipients</subject><subject>Patients</subject><subject>Physicians</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>Prevalence</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Protein C</subject><subject>Protein deficiency</subject><subject>Protein S</subject><subject>Proteins</subject><subject>Prothrombin</subject><subject>Prothrombin gene</subject><subject>Risk factors</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Thromboembolism</subject><subject>Thrombophilia - complications</subject><subject>Thrombophilia - diagnosis</subject><subject>Thrombophilia - genetics</subject><subject>Thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & implants</subject><issn>0268-3369</issn><issn>1476-5365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kkuLFDEUhQtRnHZ061KC4uyqzbuqlsPgCwZ0oeuQSt1YaVJJm6QH_CH-X1NY0CojWQTCd8595DTNc4L3BLP-TT7sx6XsSYcFEfJBsyO8k61gUjxsdpjKvmVMDhfNk5wPGBPOsXjcXBBJBOGk3zU_Pye40x6CARQtcmGG5ApM6JhimVNcxlicQXoMMS3au-IgIx0mZCCUpD26gxBPGRldZiiQ2gRer_pNnF2upmjWsOgSj9HBapcLLNXBe1Q9Qj56HUpGCYw7uuqbnzaPrPYZnm33ZfP13dsvNx_a20_vP95c37ZGEFna3naWiUFMdjSEEUx7Qq01nZzYiDGAJKbjw9QJIQbGsOy7vufDKAmndGJ8ZJfN1W_fOu33E-SiFpfXvnSAOpWqCk4xphV89Q94iKcUam-KSk7JgPsBV-rlfykiJZeckbPVt7p25YKNdQdmrauuSU8Z7wRZC-7voeqZYHEmBrCuvv8luPpDMIP2Zc7Rn4qLId_rbFLMOYFVx-QWnX4ogtWaKZUPqmZKbZmqghfbVKdxgemMbyGqwOsN0Nlob-uXGpfPXEcp7-oSfwFjY9Tv</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>ABDELKEFI, A</creator><creator>BEN ROMDHANE, N</creator><creator>LADEB, F</creator><creator>BEN ABDELADHIM, A</creator><creator>KRIAA, A</creator><creator>CHELLI, M</creator><creator>TORJMAN, L</creator><creator>LADEB, S</creator><creator>BEN OTHMAN, T</creator><creator>LAKHAL, A</creator><creator>GUERMAZI, S</creator><creator>BEN HASSEN, A</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients</title><author>ABDELKEFI, A ; BEN ROMDHANE, N ; LADEB, F ; BEN ABDELADHIM, A ; KRIAA, A ; CHELLI, M ; TORJMAN, L ; LADEB, S ; BEN OTHMAN, T ; LAKHAL, A ; GUERMAZI, S ; BEN HASSEN, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-8f7f3595dfbc13102812ffc76d3b00ee61c749d755593306878849b61422d34b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abnormalities</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antithrombin</topic><topic>Biological and medical sciences</topic><topic>Blood clot</topic><topic>Blood coagulation</topic><topic>Blood Coagulation Factors - genetics</topic><topic>Bone marrow</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Care and treatment</topic><topic>Catheterization - adverse effects</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Catheters</topic><topic>Coagulation factors</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Emergency and intensive care: techniques, logistics</topic><topic>Factor V</topic><topic>Family Health</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Health aspects</topic><topic>Health services</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Markers</topic><topic>Medical instruments</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Organ transplant recipients</topic><topic>Patients</topic><topic>Physicians</topic><topic>Polyurethane</topic><topic>Polyurethane resins</topic><topic>Prevalence</topic><topic>Prevention</topic><topic>Prospective Studies</topic><topic>Protein C</topic><topic>Protein deficiency</topic><topic>Protein S</topic><topic>Proteins</topic><topic>Prothrombin</topic><topic>Prothrombin gene</topic><topic>Risk factors</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Thromboembolism</topic><topic>Thrombophilia - complications</topic><topic>Thrombophilia - diagnosis</topic><topic>Thrombophilia - genetics</topic><topic>Thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Transfusions. Complications. Transfusion reactions. 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We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or <24 h after, catheter removal, and in case of clinical signs of thrombosis. A total of 171 patients were included during the 28-month study period. Five (2.9%) and three (1.7%) patients had evidence of protein C and protein S deficiency, respectively. Only one patient had an antithrombin deficiency (0.6%). In total, 10 patients (5.8%) were heterozygous for the factor V Leiden mutation, and one patient had heterozygous prothrombin G20210A mutation (0.6%). We observed a CVC-related thrombosis in 13 patients (7.6%). Thrombosis was diagnosed in four out of 20 patients (20%) with a inherited prothrombotic abnormality compared to nine of 151 patients (6%) who did not have a thrombophilic marker (relative risk 3.3 CI 95% 1.1-9.9). Our results suggest that inherited prothrombotic abnormalities contribute substantially to CVC-related thrombosis in HSCT recipients. In view of physicians' reluctance to prescribe prophylactic anticoagulant treatment in these patients, a priori determination of inherited prothrombotic abnormalities may form a basis to guide these treatment decisions.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>16151418</pmid><doi>10.1038/sj.bmt.1705156</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2005-11, Vol.36 (10), p.885-889 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68742002 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abnormalities Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antithrombin Biological and medical sciences Blood clot Blood coagulation Blood Coagulation Factors - genetics Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Catheterization - adverse effects Catheterization, Central Venous - adverse effects Catheters Coagulation factors Complications and side effects Diagnosis Emergency and intensive care: techniques, logistics Factor V Family Health Female Genetic Predisposition to Disease Health aspects Health services Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Intensive care medicine Male Markers Medical instruments Medical sciences Middle Aged Mutation Organ transplant recipients Patients Physicians Polyurethane Polyurethane resins Prevalence Prevention Prospective Studies Protein C Protein deficiency Protein S Proteins Prothrombin Prothrombin gene Risk factors Stem cell transplantation Stem cells Thromboembolism Thrombophilia - complications Thrombophilia - diagnosis Thrombophilia - genetics Thrombosis Thrombosis - etiology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplants Transplants & implants |
| title | Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A49%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20of%20inherited%20prothrombotic%20abnormalities%20and%20central%20venous%20catheter-related%20thrombosis%20in%20haematopoietic%20stem%20cell%20transplants%20recipients&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=ABDELKEFI,%20A&rft.date=2005-11-01&rft.volume=36&rft.issue=10&rft.spage=885&rft.epage=889&rft.pages=885-889&rft.issn=0268-3369&rft.eissn=1476-5365&rft.coden=BMTRE9&rft_id=info:doi/10.1038/sj.bmt.1705156&rft_dat=%3Cgale_proqu%3EA182347512%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=216646431&rft_id=info:pmid/16151418&rft_galeid=A182347512&rfr_iscdi=true |