Prevalence of inherited prothrombotic abnormalities and central venous catheter-related thrombosis in haematopoietic stem cell transplants recipients

In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients....

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2005-11, Vol.36 (10), p.885-889
Hauptverfasser:	ABDELKEFI, A, BEN ROMDHANE, N, LADEB, F, BEN ABDELADHIM, A, KRIAA, A, CHELLI, M, TORJMAN, L, LADEB, S, BEN OTHMAN, T, LAKHAL, A, GUERMAZI, S, BEN HASSEN, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antithrombin Biological and medical sciences Blood clot Blood coagulation Blood Coagulation Factors - genetics Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Catheterization - adverse effects Catheterization, Central Venous - adverse effects Catheters Coagulation factors Complications and side effects Diagnosis Emergency and intensive care: techniques, logistics Factor V Family Health Female Genetic Predisposition to Disease Health aspects Health services Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Intensive care medicine Male Markers Medical instruments Medical sciences Middle Aged Mutation Organ transplant recipients Patients Physicians Polyurethane Polyurethane resins Prevalence Prevention Prospective Studies Protein C Protein deficiency Protein S Proteins Prothrombin Prothrombin gene Risk factors Stem cell transplantation Stem cells Thromboembolism Thrombophilia - complications Thrombophilia - diagnosis Thrombophilia - genetics Thrombosis Thrombosis - etiology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplants Transplants & implants
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Zusammenfassung:	In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1705156