Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants
Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection. The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible...
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| Veröffentlicht in: | International journal of infectious diseases 2006-09, Vol.10 (5), p.354-357 |
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| container_title | International journal of infectious diseases |
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| creator | Bustos, Dolores Biganzoli, Patricia Carricart, Silvia Ethel Ferreyra, Leonardo Nates, Silvia Viviana Pavan, Jorge Victorio |
| description | Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection.
The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection.
Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence.
The seropositive ratio fell in the 2–4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2–4 months (GMT
=
60) were statistically different (
p
<
0.0001, Student's
t-test) to those from the group of pregnant women (GMT
=
83) and those from the other infant groups (
p
<
0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT
=
179, 79% seropositive) were different from all the groups studied (
p
<
0.0001, LSD test).
This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries. |
| doi_str_mv | 10.1016/j.ijid.2005.07.005 |
| format | Article |
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The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection.
Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence.
The seropositive ratio fell in the 2–4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2–4 months (GMT
=
60) were statistically different (
p
<
0.0001, Student's
t-test) to those from the group of pregnant women (GMT
=
83) and those from the other infant groups (
p
<
0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT
=
179, 79% seropositive) were different from all the groups studied (
p
<
0.0001, LSD test).
This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries.</description><identifier>ISSN: 1201-9712</identifier><identifier>EISSN: 1878-3511</identifier><identifier>DOI: 10.1016/j.ijid.2005.07.005</identifier><identifier>PMID: 16857404</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adult ; Antibodies, Viral - blood ; Antibody ; Argentina - epidemiology ; Argentinian infants ; Biological and medical sciences ; Child, Preschool ; Female ; Fluorescent Antibody Technique, Indirect - methods ; Herpesvirus 7, Human - immunology ; HHV-7 ; Humans ; Immunity, Maternally-Acquired - immunology ; Infant ; Infectious diseases ; Male ; Medical sciences ; Natural infection ; Pregnancy ; Roseolovirus Infections - epidemiology ; Roseolovirus Infections - immunology</subject><ispartof>International journal of infectious diseases, 2006-09, Vol.10 (5), p.354-357</ispartof><rights>2005 International Society for Infectious Diseases</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-93c8716ae9551f66c0df9add56b522d018b2f3b552e156f660897470ca2fc3443</citedby><cites>FETCH-LOGICAL-c428t-93c8716ae9551f66c0df9add56b522d018b2f3b552e156f660897470ca2fc3443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijid.2005.07.005$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18084366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16857404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bustos, Dolores</creatorcontrib><creatorcontrib>Biganzoli, Patricia</creatorcontrib><creatorcontrib>Carricart, Silvia Ethel</creatorcontrib><creatorcontrib>Ferreyra, Leonardo</creatorcontrib><creatorcontrib>Nates, Silvia Viviana</creatorcontrib><creatorcontrib>Pavan, Jorge Victorio</creatorcontrib><title>Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants</title><title>International journal of infectious diseases</title><addtitle>Int J Infect Dis</addtitle><description>Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection.
The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection.
Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence.
The seropositive ratio fell in the 2–4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2–4 months (GMT
=
60) were statistically different (
p
<
0.0001, Student's
t-test) to those from the group of pregnant women (GMT
=
83) and those from the other infant groups (
p
<
0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT
=
179, 79% seropositive) were different from all the groups studied (
p
<
0.0001, LSD test).
This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Antibody</subject><subject>Argentina - epidemiology</subject><subject>Argentinian infants</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect - methods</subject><subject>Herpesvirus 7, Human - immunology</subject><subject>HHV-7</subject><subject>Humans</subject><subject>Immunity, Maternally-Acquired - immunology</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Natural infection</subject><subject>Pregnancy</subject><subject>Roseolovirus Infections - epidemiology</subject><subject>Roseolovirus Infections - immunology</subject><issn>1201-9712</issn><issn>1878-3511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaNKkf6CH4kt7szuS9WXoJYR-wUIvyVlopVGjxZa3kr2w_z5adiG3nt4ZeGaYeQj5SKGjQOXXXRd30XcMQHSguhpvyA3VSre9oPRtrRnQdlCUXZP3pewAgEup35FrKrVQHPgN8Zu5lGYOzWQXzMmO47H1mOMBffO8TjY1z5j3WA4xr6VVTZymNcXl2Njkm2SXNduxiSmgW-KcatXc57-YlpiiPbXBpqXckatgx4IfLnlLnn58f3z41W7-_Pz9cL9pHWd6aYfeaUWlxUEIGqR04MNgvRdyKxjzQPWWhX4rBEMqZAVAD4orcJYF13Pe35Iv5737PP9bsSxmisXhONqE81qM1IpTNkAF2Rl0ub6fMZh9jpPNR0PBnNyanTm5NSe3BpSpUYc-Xbav2wn968hFZgU-XwBbnB1DtsnF8spp0LyXsnLfzhxWF4eI2RQXMTn0MVePxs_xf3e8ABgjmHI</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Bustos, Dolores</creator><creator>Biganzoli, Patricia</creator><creator>Carricart, Silvia Ethel</creator><creator>Ferreyra, Leonardo</creator><creator>Nates, Silvia Viviana</creator><creator>Pavan, Jorge Victorio</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060901</creationdate><title>Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants</title><author>Bustos, Dolores ; Biganzoli, Patricia ; Carricart, Silvia Ethel ; Ferreyra, Leonardo ; Nates, Silvia Viviana ; Pavan, Jorge Victorio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-93c8716ae9551f66c0df9add56b522d018b2f3b552e156f660897470ca2fc3443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>Antibody</topic><topic>Argentina - epidemiology</topic><topic>Argentinian infants</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect - methods</topic><topic>Herpesvirus 7, Human - immunology</topic><topic>HHV-7</topic><topic>Humans</topic><topic>Immunity, Maternally-Acquired - immunology</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Natural infection</topic><topic>Pregnancy</topic><topic>Roseolovirus Infections - epidemiology</topic><topic>Roseolovirus Infections - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bustos, Dolores</creatorcontrib><creatorcontrib>Biganzoli, Patricia</creatorcontrib><creatorcontrib>Carricart, Silvia Ethel</creatorcontrib><creatorcontrib>Ferreyra, Leonardo</creatorcontrib><creatorcontrib>Nates, Silvia Viviana</creatorcontrib><creatorcontrib>Pavan, Jorge Victorio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bustos, Dolores</au><au>Biganzoli, Patricia</au><au>Carricart, Silvia Ethel</au><au>Ferreyra, Leonardo</au><au>Nates, Silvia Viviana</au><au>Pavan, Jorge Victorio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants</atitle><jtitle>International journal of infectious diseases</jtitle><addtitle>Int J Infect Dis</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>10</volume><issue>5</issue><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>1201-9712</issn><eissn>1878-3511</eissn><abstract>Human herpes virus-7 (HHV-7) infection is widespread throughout the world. No data are available in Argentina about loss of maternally-derived HHV-7 immunity and natural infection.
The objective of this study was to characterize the time when children lose maternal antibodies and become susceptible to natural infection.
Sera from 39 pregnant women and 207 infants between 2 and 29 months of age were tested. Determination of IgG antibodies was made by indirect immunofluorescence.
The seropositive ratio fell in the 2–4 month group (15% seropositive) and increased between 5 months (47% seropositive) and 23 months (67%). Geometric mean titers (GMT) of the infants aged 2–4 months (GMT
=
60) were statistically different (
p
<
0.0001, Student's
t-test) to those from the group of pregnant women (GMT
=
83) and those from the other infant groups (
p
<
0.001, least significant difference (LSD) test). The GMT of the groups between 5 and 23 months did not show significant differences whereas those of infants between 24 and 29 months (GMT
=
179, 79% seropositive) were different from all the groups studied (
p
<
0.0001, LSD test).
This study shows a significant association between the loss of passive HHV-7 antibody and age. HHV-7 enters the susceptible population at 5 months, leading to the high prevalence of antibodies between 24 and 29 months of age. This study also shows that natural infection by HHV-7 in children during their first years of life follows the infection pattern found in developing countries.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>16857404</pmid><doi>10.1016/j.ijid.2005.07.005</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of infectious diseases, 2006-09, Vol.10 (5), p.354-357 |
| issn | 1201-9712 1878-3511 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antibodies, Viral - blood Antibody Argentina - epidemiology Argentinian infants Biological and medical sciences Child, Preschool Female Fluorescent Antibody Technique, Indirect - methods Herpesvirus 7, Human - immunology HHV-7 Humans Immunity, Maternally-Acquired - immunology Infant Infectious diseases Male Medical sciences Natural infection Pregnancy Roseolovirus Infections - epidemiology Roseolovirus Infections - immunology |
| title | Loss of maternally-derived human herpesvirus-7 immunity and natural infection in Argentinian infants |
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