Inhibitory modulation of ATP-sensitive potassium channels by gallate-ester moiety of (−)-epigallocatechin-3-gallate

(−)-Epigallocatechin-3-gallate (EGCG), a major polyphenolic substance found in green tea, is well recognized to be beneficial for human health. However, it is still controversial as to what dose of this compound is indeed good for human health. Though some recent studies have interestingly reported...

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Veröffentlicht in:	Biochemical pharmacology 2005-11, Vol.70 (11), p.1560-1567
Hauptverfasser:	Baek, Won-Ki, Jang, Byeong-Churl, Lim, Jun Hee, Kwon, Taeg-Kyu, Lee, Hyun-Young, Cho, Chi-Heum, Kim, Dae-Kwang, Shin, Dong-Hoon, Park, Jong-Gu, Lim, Jeong-Geun, Bae, Ji-Hyun, Bae, Jae-Hoon, Yoo, Sun Kyun, Park, Won-Kyun, Song, Dae-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals ATP-sensitive potassium channel Biological and medical sciences Catechin - analogs & derivatives Catechin - chemistry Catechin - pharmacology Cell Membrane - drug effects Cell Membrane - metabolism EGCG Gallate-ester moiety General pharmacology Ion Channel Gating - drug effects Islets of Langerhans - cytology Kir6.2 Medical sciences Membrane Potentials - drug effects Molecular Structure Oocytes - drug effects Oocytes - metabolism Pancreatic β-cell Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Potassium Channel Blockers - chemistry Potassium Channel Blockers - pharmacology Potassium Channels, Inwardly Rectifying - antagonists & inhibitors Potassium Channels, Inwardly Rectifying - metabolism Protein Subunits Structure-Activity Relationship Xenopus laevis Xenopus oocyte
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