Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma

Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To clarify this issue, we studie...

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Veröffentlicht in:	Clinical cancer research 2006-08, Vol.12 (15), p.4491-4498
Hauptverfasser:	FELDMANN, Georg, NISCHALKE, Hans Dieter, SAUERBRUCH, Tilman, CASELMANN, Wolfgang H, SPENGLER, Ulrich, NATTERMANN, Jacob, BANAS, Brigitte, BERG, Thomas, TESCHENDORF, Christian, SCHMIEGEL, Wolff, DUHRSEN, Ulrich, HALANGK, Juliane, IWAN, Agathe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over B-cell lymphoma Biological and medical sciences Cell Proliferation Cryoglobulinemia - blood Cryoglobulinemia - etiology Female Hematologic and hematopoietic diseases Hepacivirus - immunology Hepatitis C Hepatitis C - blood Hepatitis C - complications Hepatitis C - immunology Hepatitis C virus Human viral diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Infectious diseases interleukin-6 Interleukin-6 - biosynthesis Interleukin-6 - blood Interleukin-8 - biosynthesis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes, Mononuclear - immunology Lymphoma, B-Cell - blood Lymphoma, B-Cell - etiology Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - etiology Male Medical sciences Middle Aged mixed cryoglobulinemia Recombinant Proteins - blood Recombinant Proteins - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors Up-Regulation Viral Core Proteins - immunology Viral diseases Viral hepatitis
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