Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma
Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To clarify this issue, we studie...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 2006-08, Vol.12 (15), p.4491-4498 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4498 |
|---|---|
| container_issue | 15 |
| container_start_page | 4491 |
| container_title | Clinical cancer research |
| container_volume | 12 |
| creator | FELDMANN, Georg NISCHALKE, Hans Dieter SAUERBRUCH, Tilman CASELMANN, Wolfgang H SPENGLER, Ulrich NATTERMANN, Jacob BANAS, Brigitte BERG, Thomas TESCHENDORF, Christian SCHMIEGEL, Wolff DUHRSEN, Ulrich HALANGK, Juliane IWAN, Agathe |
| description | Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly
because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To
clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis
of HCV-associated MC or B-NHL.
Experimental Design: Peripheral blood mononuclear cells of patients with HCV-associated B-NHL ( n = 12), MC ( n = 14), uncomplicated hepatitis C ( n = 12), and healthy volunteers ( n = 12) were incubated with the recombinant HCV proteins E2, core, and NS3 to study induction of cytokine production, stimulation
of B-cell proliferation, and immunoglobulin secretion. In addition, serum levels of interleukin-6 (IL-6) were measured by
ELISA.
Results: HCV core was the only studied protein, which induced production of IL-6 and IL-8 in CD14 + cells. IL-6 induction was mediated via Toll-like receptor 2 (TLR2) and lead to increased B-cell proliferation in vitro . TLR2 expression on monocytes and IL-6 serum concentrations were increased in all groups of HCV-infected patients compared
with healthy controls and were highest in MC ( P < 0.05).
Conclusions: Increased secretion of IL-6 via stimulation of TLR2 by HCV core protein may play a role in the pathogenesis of hepatitis
C–associated MC and B-NHL. |
| doi_str_mv | 10.1158/1078-0432.CCR-06-0154 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68740162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68740162</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-5a29b21719a6e89c3eed8c9155d2c15107d48b98bf2dee1c7eb126053120aa973</originalsourceid><addsrcrecordid>eNqFkc-O0zAQhyMEYpeFRwD5AohDFo8TO_ZxiYBWKn-EgKvlONPWkNhdOxH0xjvsG_IkuGrRckOyPD58P8_YX1E8BnoJwOVLoI0saV2xy7b9VFJRUuD1neIcOG_Kigl-N5__MmfFg5S-UQo10Pp-cQZCKsVVfV7cLH0_28kFT8KaLP2EccD5u_OlIN2eLHBnJje5RFry1cU51xCRfIxhQudJXv8Qv3_dXKUUrDMT9uSd-5n3Nu7DZgjdPDiPozPE-J68KlscBvI--BxZhH6T-z1PZLUfd9swmofFvbUZEj461Yviy5vXn9tFufrwdtlerUrLgU8lN0x1DBpQRqBUtkLspVX5A3pmgefH97XslOzWrEcE22AHTFBeAaPGqKa6KJ4d793FcD1jmvToks2TGY9hTlrIpqYg2H9BUEo0EmgG-RG0MaQUca130Y0m7jVQfdCmD0r0QYnO2jQV-qAt556cGszdiP1t6uQpA09PgEnWDOtovHXplpO0YqyRmXtx5LZus_3hImqbSYwRE5potxqYBq7rWkH1B2TAsPM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19967810</pqid></control><display><type>article</type><title>Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>American Association for Cancer Research</source><source>Alma/SFX Local Collection</source><creator>FELDMANN, Georg ; NISCHALKE, Hans Dieter ; SAUERBRUCH, Tilman ; CASELMANN, Wolfgang H ; SPENGLER, Ulrich ; NATTERMANN, Jacob ; BANAS, Brigitte ; BERG, Thomas ; TESCHENDORF, Christian ; SCHMIEGEL, Wolff ; DUHRSEN, Ulrich ; HALANGK, Juliane ; IWAN, Agathe</creator><creatorcontrib>FELDMANN, Georg ; NISCHALKE, Hans Dieter ; SAUERBRUCH, Tilman ; CASELMANN, Wolfgang H ; SPENGLER, Ulrich ; NATTERMANN, Jacob ; BANAS, Brigitte ; BERG, Thomas ; TESCHENDORF, Christian ; SCHMIEGEL, Wolff ; DUHRSEN, Ulrich ; HALANGK, Juliane ; IWAN, Agathe</creatorcontrib><description>Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly
because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To
clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis
of HCV-associated MC or B-NHL.
Experimental Design: Peripheral blood mononuclear cells of patients with HCV-associated B-NHL ( n = 12), MC ( n = 14), uncomplicated hepatitis C ( n = 12), and healthy volunteers ( n = 12) were incubated with the recombinant HCV proteins E2, core, and NS3 to study induction of cytokine production, stimulation
of B-cell proliferation, and immunoglobulin secretion. In addition, serum levels of interleukin-6 (IL-6) were measured by
ELISA.
Results: HCV core was the only studied protein, which induced production of IL-6 and IL-8 in CD14 + cells. IL-6 induction was mediated via Toll-like receptor 2 (TLR2) and lead to increased B-cell proliferation in vitro . TLR2 expression on monocytes and IL-6 serum concentrations were increased in all groups of HCV-infected patients compared
with healthy controls and were highest in MC ( P < 0.05).
Conclusions: Increased secretion of IL-6 via stimulation of TLR2 by HCV core protein may play a role in the pathogenesis of hepatitis
C–associated MC and B-NHL.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-06-0154</identifier><identifier>PMID: 16899594</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; B-cell lymphoma ; Biological and medical sciences ; Cell Proliferation ; Cryoglobulinemia - blood ; Cryoglobulinemia - etiology ; Female ; Hematologic and hematopoietic diseases ; Hepacivirus - immunology ; Hepatitis C ; Hepatitis C - blood ; Hepatitis C - complications ; Hepatitis C - immunology ; Hepatitis C virus ; Human viral diseases ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; interleukin-6 ; Interleukin-6 - biosynthesis ; Interleukin-6 - blood ; Interleukin-8 - biosynthesis ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocytes, Mononuclear - immunology ; Lymphoma, B-Cell - blood ; Lymphoma, B-Cell - etiology ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - etiology ; Male ; Medical sciences ; Middle Aged ; mixed cryoglobulinemia ; Recombinant Proteins - blood ; Recombinant Proteins - metabolism ; Toll-Like Receptor 2 - genetics ; Toll-Like Receptor 2 - metabolism ; Toll-like receptors ; Up-Regulation ; Viral Core Proteins - immunology ; Viral diseases ; Viral hepatitis</subject><ispartof>Clinical cancer research, 2006-08, Vol.12 (15), p.4491-4498</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-5a29b21719a6e89c3eed8c9155d2c15107d48b98bf2dee1c7eb126053120aa973</citedby><cites>FETCH-LOGICAL-c515t-5a29b21719a6e89c3eed8c9155d2c15107d48b98bf2dee1c7eb126053120aa973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3357,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18032278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16899594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FELDMANN, Georg</creatorcontrib><creatorcontrib>NISCHALKE, Hans Dieter</creatorcontrib><creatorcontrib>SAUERBRUCH, Tilman</creatorcontrib><creatorcontrib>CASELMANN, Wolfgang H</creatorcontrib><creatorcontrib>SPENGLER, Ulrich</creatorcontrib><creatorcontrib>NATTERMANN, Jacob</creatorcontrib><creatorcontrib>BANAS, Brigitte</creatorcontrib><creatorcontrib>BERG, Thomas</creatorcontrib><creatorcontrib>TESCHENDORF, Christian</creatorcontrib><creatorcontrib>SCHMIEGEL, Wolff</creatorcontrib><creatorcontrib>DUHRSEN, Ulrich</creatorcontrib><creatorcontrib>HALANGK, Juliane</creatorcontrib><creatorcontrib>IWAN, Agathe</creatorcontrib><title>Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly
because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To
clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis
of HCV-associated MC or B-NHL.
Experimental Design: Peripheral blood mononuclear cells of patients with HCV-associated B-NHL ( n = 12), MC ( n = 14), uncomplicated hepatitis C ( n = 12), and healthy volunteers ( n = 12) were incubated with the recombinant HCV proteins E2, core, and NS3 to study induction of cytokine production, stimulation
of B-cell proliferation, and immunoglobulin secretion. In addition, serum levels of interleukin-6 (IL-6) were measured by
ELISA.
Results: HCV core was the only studied protein, which induced production of IL-6 and IL-8 in CD14 + cells. IL-6 induction was mediated via Toll-like receptor 2 (TLR2) and lead to increased B-cell proliferation in vitro . TLR2 expression on monocytes and IL-6 serum concentrations were increased in all groups of HCV-infected patients compared
with healthy controls and were highest in MC ( P < 0.05).
Conclusions: Increased secretion of IL-6 via stimulation of TLR2 by HCV core protein may play a role in the pathogenesis of hepatitis
C–associated MC and B-NHL.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B-cell lymphoma</subject><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>Cryoglobulinemia - blood</subject><subject>Cryoglobulinemia - etiology</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis C</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>interleukin-6</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Lymphoma, B-Cell - blood</subject><subject>Lymphoma, B-Cell - etiology</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mixed cryoglobulinemia</subject><subject>Recombinant Proteins - blood</subject><subject>Recombinant Proteins - metabolism</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 2 - metabolism</subject><subject>Toll-like receptors</subject><subject>Up-Regulation</subject><subject>Viral Core Proteins - immunology</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-O0zAQhyMEYpeFRwD5AohDFo8TO_ZxiYBWKn-EgKvlONPWkNhdOxH0xjvsG_IkuGrRckOyPD58P8_YX1E8BnoJwOVLoI0saV2xy7b9VFJRUuD1neIcOG_Kigl-N5__MmfFg5S-UQo10Pp-cQZCKsVVfV7cLH0_28kFT8KaLP2EccD5u_OlIN2eLHBnJje5RFry1cU51xCRfIxhQudJXv8Qv3_dXKUUrDMT9uSd-5n3Nu7DZgjdPDiPozPE-J68KlscBvI--BxZhH6T-z1PZLUfd9swmofFvbUZEj461Yviy5vXn9tFufrwdtlerUrLgU8lN0x1DBpQRqBUtkLspVX5A3pmgefH97XslOzWrEcE22AHTFBeAaPGqKa6KJ4d793FcD1jmvToks2TGY9hTlrIpqYg2H9BUEo0EmgG-RG0MaQUca130Y0m7jVQfdCmD0r0QYnO2jQV-qAt556cGszdiP1t6uQpA09PgEnWDOtovHXplpO0YqyRmXtx5LZus_3hImqbSYwRE5potxqYBq7rWkH1B2TAsPM</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>FELDMANN, Georg</creator><creator>NISCHALKE, Hans Dieter</creator><creator>SAUERBRUCH, Tilman</creator><creator>CASELMANN, Wolfgang H</creator><creator>SPENGLER, Ulrich</creator><creator>NATTERMANN, Jacob</creator><creator>BANAS, Brigitte</creator><creator>BERG, Thomas</creator><creator>TESCHENDORF, Christian</creator><creator>SCHMIEGEL, Wolff</creator><creator>DUHRSEN, Ulrich</creator><creator>HALANGK, Juliane</creator><creator>IWAN, Agathe</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma</title><author>FELDMANN, Georg ; NISCHALKE, Hans Dieter ; SAUERBRUCH, Tilman ; CASELMANN, Wolfgang H ; SPENGLER, Ulrich ; NATTERMANN, Jacob ; BANAS, Brigitte ; BERG, Thomas ; TESCHENDORF, Christian ; SCHMIEGEL, Wolff ; DUHRSEN, Ulrich ; HALANGK, Juliane ; IWAN, Agathe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-5a29b21719a6e89c3eed8c9155d2c15107d48b98bf2dee1c7eb126053120aa973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B-cell lymphoma</topic><topic>Biological and medical sciences</topic><topic>Cell Proliferation</topic><topic>Cryoglobulinemia - blood</topic><topic>Cryoglobulinemia - etiology</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hepacivirus - immunology</topic><topic>Hepatitis C</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>interleukin-6</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Lymphoma, B-Cell - blood</topic><topic>Lymphoma, B-Cell - etiology</topic><topic>Lymphoma, Non-Hodgkin - blood</topic><topic>Lymphoma, Non-Hodgkin - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mixed cryoglobulinemia</topic><topic>Recombinant Proteins - blood</topic><topic>Recombinant Proteins - metabolism</topic><topic>Toll-Like Receptor 2 - genetics</topic><topic>Toll-Like Receptor 2 - metabolism</topic><topic>Toll-like receptors</topic><topic>Up-Regulation</topic><topic>Viral Core Proteins - immunology</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELDMANN, Georg</creatorcontrib><creatorcontrib>NISCHALKE, Hans Dieter</creatorcontrib><creatorcontrib>SAUERBRUCH, Tilman</creatorcontrib><creatorcontrib>CASELMANN, Wolfgang H</creatorcontrib><creatorcontrib>SPENGLER, Ulrich</creatorcontrib><creatorcontrib>NATTERMANN, Jacob</creatorcontrib><creatorcontrib>BANAS, Brigitte</creatorcontrib><creatorcontrib>BERG, Thomas</creatorcontrib><creatorcontrib>TESCHENDORF, Christian</creatorcontrib><creatorcontrib>SCHMIEGEL, Wolff</creatorcontrib><creatorcontrib>DUHRSEN, Ulrich</creatorcontrib><creatorcontrib>HALANGK, Juliane</creatorcontrib><creatorcontrib>IWAN, Agathe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FELDMANN, Georg</au><au>NISCHALKE, Hans Dieter</au><au>SAUERBRUCH, Tilman</au><au>CASELMANN, Wolfgang H</au><au>SPENGLER, Ulrich</au><au>NATTERMANN, Jacob</au><au>BANAS, Brigitte</au><au>BERG, Thomas</au><au>TESCHENDORF, Christian</au><au>SCHMIEGEL, Wolff</au><au>DUHRSEN, Ulrich</au><au>HALANGK, Juliane</au><au>IWAN, Agathe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>12</volume><issue>15</issue><spage>4491</spage><epage>4498</epage><pages>4491-4498</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Chronic hepatitis C carries the risk to develop mixed cryoglobulinemia (MC) and B-cell non–Hodgkin's lymphoma (B-NHL), possibly
because viral antigens stimulate the host's inflammatory response via extracellular pattern recognition receptors (PRR). To
clarify this issue, we studied whether recognition of hepatitis C virus (HCV) proteins by PRR is involved in the pathogenesis
of HCV-associated MC or B-NHL.
Experimental Design: Peripheral blood mononuclear cells of patients with HCV-associated B-NHL ( n = 12), MC ( n = 14), uncomplicated hepatitis C ( n = 12), and healthy volunteers ( n = 12) were incubated with the recombinant HCV proteins E2, core, and NS3 to study induction of cytokine production, stimulation
of B-cell proliferation, and immunoglobulin secretion. In addition, serum levels of interleukin-6 (IL-6) were measured by
ELISA.
Results: HCV core was the only studied protein, which induced production of IL-6 and IL-8 in CD14 + cells. IL-6 induction was mediated via Toll-like receptor 2 (TLR2) and lead to increased B-cell proliferation in vitro . TLR2 expression on monocytes and IL-6 serum concentrations were increased in all groups of HCV-infected patients compared
with healthy controls and were highest in MC ( P < 0.05).
Conclusions: Increased secretion of IL-6 via stimulation of TLR2 by HCV core protein may play a role in the pathogenesis of hepatitis
C–associated MC and B-NHL.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16899594</pmid><doi>10.1158/1078-0432.CCR-06-0154</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2006-08, Vol.12 (15), p.4491-4498 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68740162 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over B-cell lymphoma Biological and medical sciences Cell Proliferation Cryoglobulinemia - blood Cryoglobulinemia - etiology Female Hematologic and hematopoietic diseases Hepacivirus - immunology Hepatitis C Hepatitis C - blood Hepatitis C - complications Hepatitis C - immunology Hepatitis C virus Human viral diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Infectious diseases interleukin-6 Interleukin-6 - biosynthesis Interleukin-6 - blood Interleukin-8 - biosynthesis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes, Mononuclear - immunology Lymphoma, B-Cell - blood Lymphoma, B-Cell - etiology Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - etiology Male Medical sciences Middle Aged mixed cryoglobulinemia Recombinant Proteins - blood Recombinant Proteins - metabolism Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors Up-Regulation Viral Core Proteins - immunology Viral diseases Viral hepatitis |
| title | Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T03%3A32%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Induction%20of%20Interleukin-6%20by%20Hepatitis%20C%20Virus%20Core%20Protein%20in%20Hepatitis%20C%E2%80%93Associated%20Mixed%20Cryoglobulinemia%20and%20B-Cell%20Non%E2%80%93Hodgkin's%20Lymphoma&rft.jtitle=Clinical%20cancer%20research&rft.au=FELDMANN,%20Georg&rft.date=2006-08-01&rft.volume=12&rft.issue=15&rft.spage=4491&rft.epage=4498&rft.pages=4491-4498&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/10.1158/1078-0432.CCR-06-0154&rft_dat=%3Cproquest_cross%3E68740162%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19967810&rft_id=info:pmid/16899594&rfr_iscdi=true |