Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

We designed and synthesized novel androgen receptor antagonists such as 8 or 9 bearing a carborane moiety. Carboranes (dicarba- closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds having remarkable chemical and thermal stability, and hydrophobic character. These...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-12, Vol.13 (23), p.6414-6424
Hauptverfasser:	Goto, Tokuhito, Ohta, Kiminori, Suzuki, Tomoharu, Ohta, Shigeru, Endo, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - chemical synthesis Androgen Antagonists - chemistry Androgen Antagonists - pharmacology Androgen receptor (AR) antagonist Androgen Receptor Antagonists Animals Biological and medical sciences Carboranes Dihydrotestosterone - metabolism Drug Design Hormones. Endocrine system Medical sciences Mice Molecular Structure NIH 3T3 Cells Pharmacology. Drug treatments Receptors, Androgen - metabolism Transcription, Genetic - drug effects
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