Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents
2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds 3a–g having structural f...
Gespeichert in:
| Veröffentlicht in: | European journal of medicinal chemistry 2006-08, Vol.41 (8), p.991-996 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 996 |
|---|---|
| container_issue | 8 |
| container_start_page | 991 |
| container_title | European journal of medicinal chemistry |
| container_volume | 41 |
| creator | Lee, Ki Yong Nam, Dong Hyuk Moon, Chang Sang Seo, Seon Hee Lee, Jae Yeol Lee, Yong Sup |
| description | 2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of
Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds
3a–g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds
3a–g were synthesized by the condensation of 2-methylchromone derivative
7 with several aromatic aldehydes. Among synthesized, compound
3e showed the significant cytotoxic activity on HCT-15 cell line with IC
50 values of 7.17 μg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application. |
| doi_str_mv | 10.1016/j.ejmech.2006.04.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68739105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0223523406001541</els_id><sourcerecordid>68739105</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-d236df2b0e9470bfe0d6b5a667ba2c2ca1ed6ab543f1dcd644accbac4bfeecb93</originalsourceid><addsrcrecordid>eNp9kMFq3DAQhkVpaTZp36AUX9qbnZEsy7uXQghtUwjk0PQspNG4q8WWU0le2LfJs-TJorALufU0h_n-n5mPsU8cGg5cXe4a2k2E20YAqAZkA7B-w1a8V-u6FZ18y1YgRFt3opVn7DylHQB0CuA9O-OqV0IqWLHx9yHkLSWfKhPc06MJ2aMJSLEymP3e50M1D0-Po9lTcEvKPlRXlaPo96asKVU4h2x88OFvZeJhpNIWDiNu4zzNgaq02BLKC4WcPrB3gxkTfTzNC_bnx_f765v69u7nr-ur2xrbDeTaiVa5QVigjezBDgRO2c4o1VsjUKDh5JSxnWwH7tApKQ2iNSgLSmg37QX7eux9iPO_hVLWk09I42gCzUvSat23Gw5dAeURxDinFGnQD9FP5Q3NQb9Y1jt9tKxfLGuQulgusc-n_sVO5F5DJ60F-HICTEIzDrEY9emVW0OrRMcL9-3IUbGx9xR1Qk_FvvORMGs3-_9f8gxilaOZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68739105</pqid></control><display><type>article</type><title>Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Lee, Ki Yong ; Nam, Dong Hyuk ; Moon, Chang Sang ; Seo, Seon Hee ; Lee, Jae Yeol ; Lee, Yong Sup</creator><creatorcontrib>Lee, Ki Yong ; Nam, Dong Hyuk ; Moon, Chang Sang ; Seo, Seon Hee ; Lee, Jae Yeol ; Lee, Yong Sup</creatorcontrib><description>2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of
Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds
3a–g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds
3a–g were synthesized by the condensation of 2-methylchromone derivative
7 with several aromatic aldehydes. Among synthesized, compound
3e showed the significant cytotoxic activity on HCT-15 cell line with IC
50 values of 7.17 μg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2006.04.008</identifier><identifier>PMID: 16762460</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Oxford: Elsevier Masson SAS</publisher><subject>Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Arylethenylchromone ; Biological and medical sciences ; Cell Line, Tumor ; Chromones - chemical synthesis ; Chromones - chemistry ; Chromones - pharmacology ; Cytotoxicity ; Drug Screening Assays, Antitumor ; General aspects ; HCT-15 ; Humans ; Lavendustin A ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacology. Drug treatments ; Phenols - chemical synthesis ; Phenols - chemistry ; Phenols - pharmacology ; Styrylchromone</subject><ispartof>European journal of medicinal chemistry, 2006-08, Vol.41 (8), p.991-996</ispartof><rights>2006 Elsevier SAS</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d236df2b0e9470bfe0d6b5a667ba2c2ca1ed6ab543f1dcd644accbac4bfeecb93</citedby><cites>FETCH-LOGICAL-c390t-d236df2b0e9470bfe0d6b5a667ba2c2ca1ed6ab543f1dcd644accbac4bfeecb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523406001541$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18036251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16762460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ki Yong</creatorcontrib><creatorcontrib>Nam, Dong Hyuk</creatorcontrib><creatorcontrib>Moon, Chang Sang</creatorcontrib><creatorcontrib>Seo, Seon Hee</creatorcontrib><creatorcontrib>Lee, Jae Yeol</creatorcontrib><creatorcontrib>Lee, Yong Sup</creatorcontrib><title>Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of
Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds
3a–g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds
3a–g were synthesized by the condensation of 2-methylchromone derivative
7 with several aromatic aldehydes. Among synthesized, compound
3e showed the significant cytotoxic activity on HCT-15 cell line with IC
50 values of 7.17 μg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application.</description><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Arylethenylchromone</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Chromones - chemical synthesis</subject><subject>Chromones - chemistry</subject><subject>Chromones - pharmacology</subject><subject>Cytotoxicity</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General aspects</subject><subject>HCT-15</subject><subject>Humans</subject><subject>Lavendustin A</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - chemical synthesis</subject><subject>Phenols - chemistry</subject><subject>Phenols - pharmacology</subject><subject>Styrylchromone</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVpaTZp36AUX9qbnZEsy7uXQghtUwjk0PQspNG4q8WWU0le2LfJs-TJorALufU0h_n-n5mPsU8cGg5cXe4a2k2E20YAqAZkA7B-w1a8V-u6FZ18y1YgRFt3opVn7DylHQB0CuA9O-OqV0IqWLHx9yHkLSWfKhPc06MJ2aMJSLEymP3e50M1D0-Po9lTcEvKPlRXlaPo96asKVU4h2x88OFvZeJhpNIWDiNu4zzNgaq02BLKC4WcPrB3gxkTfTzNC_bnx_f765v69u7nr-ur2xrbDeTaiVa5QVigjezBDgRO2c4o1VsjUKDh5JSxnWwH7tApKQ2iNSgLSmg37QX7eux9iPO_hVLWk09I42gCzUvSat23Gw5dAeURxDinFGnQD9FP5Q3NQb9Y1jt9tKxfLGuQulgusc-n_sVO5F5DJ60F-HICTEIzDrEY9emVW0OrRMcL9-3IUbGx9xR1Qk_FvvORMGs3-_9f8gxilaOZ</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Lee, Ki Yong</creator><creator>Nam, Dong Hyuk</creator><creator>Moon, Chang Sang</creator><creator>Seo, Seon Hee</creator><creator>Lee, Jae Yeol</creator><creator>Lee, Yong Sup</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents</title><author>Lee, Ki Yong ; Nam, Dong Hyuk ; Moon, Chang Sang ; Seo, Seon Hee ; Lee, Jae Yeol ; Lee, Yong Sup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-d236df2b0e9470bfe0d6b5a667ba2c2ca1ed6ab543f1dcd644accbac4bfeecb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Arylethenylchromone</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Chromones - chemical synthesis</topic><topic>Chromones - chemistry</topic><topic>Chromones - pharmacology</topic><topic>Cytotoxicity</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General aspects</topic><topic>HCT-15</topic><topic>Humans</topic><topic>Lavendustin A</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenols - chemical synthesis</topic><topic>Phenols - chemistry</topic><topic>Phenols - pharmacology</topic><topic>Styrylchromone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ki Yong</creatorcontrib><creatorcontrib>Nam, Dong Hyuk</creatorcontrib><creatorcontrib>Moon, Chang Sang</creatorcontrib><creatorcontrib>Seo, Seon Hee</creatorcontrib><creatorcontrib>Lee, Jae Yeol</creatorcontrib><creatorcontrib>Lee, Yong Sup</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ki Yong</au><au>Nam, Dong Hyuk</au><au>Moon, Chang Sang</au><au>Seo, Seon Hee</au><au>Lee, Jae Yeol</au><au>Lee, Yong Sup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>41</volume><issue>8</issue><spage>991</spage><epage>996</epage><pages>991-996</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>2-Styrylchromones, which are relatively scarce in nature, have been reported to possess potent cytotoxicities on KB cell line. Lavendustin A, a metabolite of
Streptomyces griseolavendus, has been shown to inhibit a growth of A431 cell line. Accordingly, a series of compounds
3a–g having structural features of styrylchromones and lavendustin A were synthesized and evaluated for cytotoxicity using SRB assay on four tumor cell lines. Compounds
3a–g were synthesized by the condensation of 2-methylchromone derivative
7 with several aromatic aldehydes. Among synthesized, compound
3e showed the significant cytotoxic activity on HCT-15 cell line with IC
50 values of 7.17 μg/ml indicating that lavendustin A derivatives containing 2-arylethenylchromone ring have a potential in anti-tumor application.</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><pmid>16762460</pmid><doi>10.1016/j.ejmech.2006.04.008</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2006-08, Vol.41 (8), p.991-996 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68739105 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Arylethenylchromone Biological and medical sciences Cell Line, Tumor Chromones - chemical synthesis Chromones - chemistry Chromones - pharmacology Cytotoxicity Drug Screening Assays, Antitumor General aspects HCT-15 Humans Lavendustin A Magnetic Resonance Spectroscopy Medical sciences Pharmacology. Drug treatments Phenols - chemical synthesis Phenols - chemistry Phenols - pharmacology Styrylchromone |
| title | Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T21%3A58%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%C2%A0anticancer%20activity%20of%C2%A0lavendustin%20A%20derivatives%20containing%20arylethenylchromone%20substituents&rft.jtitle=European%20journal%20of%20medicinal%20chemistry&rft.au=Lee,%20Ki%20Yong&rft.date=2006-08-01&rft.volume=41&rft.issue=8&rft.spage=991&rft.epage=996&rft.pages=991-996&rft.issn=0223-5234&rft.eissn=1768-3254&rft.coden=EJMCA5&rft_id=info:doi/10.1016/j.ejmech.2006.04.008&rft_dat=%3Cproquest_cross%3E68739105%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68739105&rft_id=info:pmid/16762460&rft_els_id=S0223523406001541&rfr_iscdi=true |