Molecular modeling, design, synthesis, and biological evaluation of novel 3′,4′-dicamphanoyl-(+)- cis-khellactone (DCK) analogs as potent anti-HIV agents

Our current studies aimed at developing new potential anti-AIDS drug candidates have focused on the design and synthesis of new DCK analogs with improved molecular water solubility. Based on the structures and biodata of previous DCK analogs, 3D-QSAR studies have been performed which resulted in two...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-12, Vol.13 (23), p.6435-6449
Hauptverfasser:	Xie, Lan, Zhao, Chun-hong, Zhou, Ting, Chen, Hai-feng, Fan, Bo-tao, Chen, Xian-hong, Ma, Jian-zhou, Li, Jing-yun, Bao, Zhuo-yi, Lo, Zhaowen, Yu, Donglei, Lee, Kuo-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line Coumarins - chemical synthesis Coumarins - chemistry Coumarins - pharmacology Drug Design HIV-1 - drug effects HIV-1 - physiology Humans Medical sciences Models, Chemical Models, Molecular Pharmacology. Drug treatments Quantitative Structure-Activity Relationship
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