Monoclonal anti-double-stranded DNA antibodies cross-react with phosphoglycerate kinase 1 and inhibit the expression and production of IL-2 in activated Jurkat T cell line

Anti-double strand DNA antibodies (anti-dsDNA) involve in lupus nephritis. However, their role in tissue damage mechanism remains unclear. In this study, a 45-kDa cognate antigen of anti-dsDNA monoclonal antibodies 9D7 was identified by two-dimensional gel electrophoresis and determined to be human...

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Veröffentlicht in:	Clinical Immunology 2006-09, Vol.120 (3), p.326-334
Hauptverfasser:	Luan, Hui-Ying, Tang, Shye-Jye, Yang, Winnie, Tsai, Chang-Youh, Sun, Guang-Huan, Sun, Kuang-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Anti-double strand DNA antibodies Antibodies, Antinuclear - immunology Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Biological and medical sciences Cross Reactions Cytokines - genetics DNA - immunology Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IL-2 Immunopathology Interleukin-2 - antagonists & inhibitors Interleukin-2 - biosynthesis Interleukin-2 - genetics Interleukin-2 - immunology Jurkat Cells Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Medical sciences Mice Phosphoglycerate Kinase - genetics Phosphoglycerate Kinase - immunology Phosphoglycerate Kinase - metabolism Phosphoglycerate kinase 1 Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics SLE T-Lymphocytes - drug effects T-Lymphocytes - enzymology T-Lymphocytes - immunology Transcription, Genetic
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