Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA

The promyelocytic leukemia protein (PML) participates in several cellular functions, including transcriptional regulation, apoptosis and maintenance of genomic stability. A key feature of this protein is its ability to induce the assembly of nuclear compartments termed PML-nuclear bodies (PML-NBs)....

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Veröffentlicht in:	Journal of cell science 2006-08, Vol.119 (16), p.3284-3295
Hauptverfasser:	Bøe, Stig Ove, Haave, Marte, Jul-Larsen, Åsne, Grudic, Amra, Bjerkvig, Rolf, Lønning, Per Eystein
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Caffeine - pharmacology Cell Nucleus Structures - genetics Cell Nucleus Structures - metabolism Cells, Cultured Central Nervous System Stimulants - pharmacology DNA Damage - drug effects DNA Damage - radiation effects DNA Repair DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - radiation effects Humans Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Promyelocytic Leukemia Protein RNA, Small Interfering - pharmacology S Phase - drug effects S Phase - radiation effects Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ultraviolet Rays Umbilical Veins - drug effects Umbilical Veins - metabolism Umbilical Veins - radiation effects Zinc Fingers
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