Effects of tadalafil on myocardial blood flow in patients with coronary artery disease
OBJECTIVEErectile dysfunction and coronary artery disease share similar risk factors. Although phosphodiesterase-5 inhibitors used to treat erectile dysfunction do not adversely affect hemodynamic parameters in patients with coronary artery disease, their effects on myocardial blood flow are unknown...
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| Veröffentlicht in: | Coronary artery disease 2006-09, Vol.17 (6), p.493-499 |
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| container_title | Coronary artery disease |
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| creator | Weinsaft, Jonathan W Hickey, Kathleen Bokhari, Sabahat Shahzad, Arsalan Bedding, Alun Costigan, Timothy M Warner, Margaret R Emmick, Jeffrey T Bergmann, Steven R |
| description | OBJECTIVEErectile dysfunction and coronary artery disease share similar risk factors. Although phosphodiesterase-5 inhibitors used to treat erectile dysfunction do not adversely affect hemodynamic parameters in patients with coronary artery disease, their effects on myocardial blood flow are unknown.
METHODSIn a randomized, double-blind, crossover study we examined the effects of tadalafil, 20 mg, compared with placebo on myocardial blood flow in patients with stable coronary artery disease (n=7, 52–73 years old). After tadalafil or placebo, myocardial blood flow was measured with positron emission tomography (nine-segment model) at rest, during maximal coronary hyperemia with adenosine, and during increased myocardial work with dobutamine. Abnormal flow was defined as myocardial blood flow |
| doi_str_mv | 10.1097/00019501-200609000-00001 |
| format | Article |
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METHODSIn a randomized, double-blind, crossover study we examined the effects of tadalafil, 20 mg, compared with placebo on myocardial blood flow in patients with stable coronary artery disease (n=7, 52–73 years old). After tadalafil or placebo, myocardial blood flow was measured with positron emission tomography (nine-segment model) at rest, during maximal coronary hyperemia with adenosine, and during increased myocardial work with dobutamine. Abnormal flow was defined as myocardial blood flow <75% of maximum perfusion during adenosine plus placebo (46 normal/17 abnormal segments dentified).
RESULTSCompared with placebo, tadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Similarly, in normal and abnormal segments, tadalafil versus placebo had no significant effect on resting myocardial blood flow or on adenosine-induced increases in myocardial blood flow. In normal segments, myocardial blood flow with dobutamine plus tadalafil was greater than that with dobutamine plus placebo (1.79±0.56 versus 1.56±0.37 ml/g per min, P<0.01), and in abnormal segments, there was a trend for tadalafil compared with placebo to increase myocardial blood flow during dobutamine infusion (1.46±0.44 versus 1.36±0.36 ml/g per min, P=0.7).
CONCLUSIONSTadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Compared with placebo, tadalafil significantly augmented myocardial blood flow during increased workload in normal regions, with a trend toward improving myocardial blood flow in poorly perfused regions.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/00019501-200609000-00001</identifier><identifier>PMID: 16905960</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adenosine - administration & dosage ; Aged ; Carbolines - pharmacology ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - physiopathology ; Coronary Circulation - drug effects ; Coronary Circulation - physiology ; Cross-Over Studies ; Dobutamine - administration & dosage ; Double-Blind Method ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Phosphodiesterase Inhibitors - pharmacology ; Radionuclide Imaging ; Tadalafil</subject><ispartof>Coronary artery disease, 2006-09, Vol.17 (6), p.493-499</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3581-9e7b16c07349c6aa6093d6b6c77cb894f56e04eb5c287d67fd6c509ac86784263</citedby><cites>FETCH-LOGICAL-c3581-9e7b16c07349c6aa6093d6b6c77cb894f56e04eb5c287d67fd6c509ac86784263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16905960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinsaft, Jonathan W</creatorcontrib><creatorcontrib>Hickey, Kathleen</creatorcontrib><creatorcontrib>Bokhari, Sabahat</creatorcontrib><creatorcontrib>Shahzad, Arsalan</creatorcontrib><creatorcontrib>Bedding, Alun</creatorcontrib><creatorcontrib>Costigan, Timothy M</creatorcontrib><creatorcontrib>Warner, Margaret R</creatorcontrib><creatorcontrib>Emmick, Jeffrey T</creatorcontrib><creatorcontrib>Bergmann, Steven R</creatorcontrib><title>Effects of tadalafil on myocardial blood flow in patients with coronary artery disease</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>OBJECTIVEErectile dysfunction and coronary artery disease share similar risk factors. Although phosphodiesterase-5 inhibitors used to treat erectile dysfunction do not adversely affect hemodynamic parameters in patients with coronary artery disease, their effects on myocardial blood flow are unknown.
METHODSIn a randomized, double-blind, crossover study we examined the effects of tadalafil, 20 mg, compared with placebo on myocardial blood flow in patients with stable coronary artery disease (n=7, 52–73 years old). After tadalafil or placebo, myocardial blood flow was measured with positron emission tomography (nine-segment model) at rest, during maximal coronary hyperemia with adenosine, and during increased myocardial work with dobutamine. Abnormal flow was defined as myocardial blood flow <75% of maximum perfusion during adenosine plus placebo (46 normal/17 abnormal segments dentified).
RESULTSCompared with placebo, tadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Similarly, in normal and abnormal segments, tadalafil versus placebo had no significant effect on resting myocardial blood flow or on adenosine-induced increases in myocardial blood flow. In normal segments, myocardial blood flow with dobutamine plus tadalafil was greater than that with dobutamine plus placebo (1.79±0.56 versus 1.56±0.37 ml/g per min, P<0.01), and in abnormal segments, there was a trend for tadalafil compared with placebo to increase myocardial blood flow during dobutamine infusion (1.46±0.44 versus 1.36±0.36 ml/g per min, P=0.7).
CONCLUSIONSTadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Compared with placebo, tadalafil significantly augmented myocardial blood flow during increased workload in normal regions, with a trend toward improving myocardial blood flow in poorly perfused regions.</description><subject>Adenosine - administration & dosage</subject><subject>Aged</subject><subject>Carbolines - pharmacology</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Circulation - physiology</subject><subject>Cross-Over Studies</subject><subject>Dobutamine - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Radionuclide Imaging</subject><subject>Tadalafil</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1PAyEQhonR2Fr9C4aTt9WhLF9H09SPpIkX9UpYFtJVulTYpvHfS23Vk6fJkOcdhgeEMIFrAkrcAABRDEg1BeCgSlvB7uwIjUktaMUkhWM0BsXqiqupHKGznN8KUDPBTtGIcAVMcRij17n3zg4ZR48H05pgfBdw7PHqM1qT2s4E3IQYW-xD3OKux2szdK4viW03LLGNKfYmfWKTBldK22VnsjtHJ96E7C4OdYJe7ubPs4dq8XT_OLtdVJYySSrlREO4BUFrZbkx5S205Q23QthGqtoz7qB2DbNTKVoufMstA2Ws5ELWU04n6Go_d53ix8blQa-6bF0IpndxkzWXggpFVQHlHrQp5pyc1-vUrcrimoDeOdU_TvWvU_3ttEQvD3dsmpVr_4IHiQWo98A2hiIhv4fN1iW9dCYMS_3fX9EvU36BWg</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Weinsaft, Jonathan W</creator><creator>Hickey, Kathleen</creator><creator>Bokhari, Sabahat</creator><creator>Shahzad, Arsalan</creator><creator>Bedding, Alun</creator><creator>Costigan, Timothy M</creator><creator>Warner, Margaret R</creator><creator>Emmick, Jeffrey T</creator><creator>Bergmann, Steven R</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Effects of tadalafil on myocardial blood flow in patients with coronary artery disease</title><author>Weinsaft, Jonathan W ; Hickey, Kathleen ; Bokhari, Sabahat ; Shahzad, Arsalan ; Bedding, Alun ; Costigan, Timothy M ; Warner, Margaret R ; Emmick, Jeffrey T ; Bergmann, Steven R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3581-9e7b16c07349c6aa6093d6b6c77cb894f56e04eb5c287d67fd6c509ac86784263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenosine - administration & dosage</topic><topic>Aged</topic><topic>Carbolines - pharmacology</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Circulation - physiology</topic><topic>Cross-Over Studies</topic><topic>Dobutamine - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Radionuclide Imaging</topic><topic>Tadalafil</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weinsaft, Jonathan W</creatorcontrib><creatorcontrib>Hickey, Kathleen</creatorcontrib><creatorcontrib>Bokhari, Sabahat</creatorcontrib><creatorcontrib>Shahzad, Arsalan</creatorcontrib><creatorcontrib>Bedding, Alun</creatorcontrib><creatorcontrib>Costigan, Timothy M</creatorcontrib><creatorcontrib>Warner, Margaret R</creatorcontrib><creatorcontrib>Emmick, Jeffrey T</creatorcontrib><creatorcontrib>Bergmann, Steven R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weinsaft, Jonathan W</au><au>Hickey, Kathleen</au><au>Bokhari, Sabahat</au><au>Shahzad, Arsalan</au><au>Bedding, Alun</au><au>Costigan, Timothy M</au><au>Warner, Margaret R</au><au>Emmick, Jeffrey T</au><au>Bergmann, Steven R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of tadalafil on myocardial blood flow in patients with coronary artery disease</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2006-09</date><risdate>2006</risdate><volume>17</volume><issue>6</issue><spage>493</spage><epage>499</epage><pages>493-499</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>OBJECTIVEErectile dysfunction and coronary artery disease share similar risk factors. Although phosphodiesterase-5 inhibitors used to treat erectile dysfunction do not adversely affect hemodynamic parameters in patients with coronary artery disease, their effects on myocardial blood flow are unknown.
METHODSIn a randomized, double-blind, crossover study we examined the effects of tadalafil, 20 mg, compared with placebo on myocardial blood flow in patients with stable coronary artery disease (n=7, 52–73 years old). After tadalafil or placebo, myocardial blood flow was measured with positron emission tomography (nine-segment model) at rest, during maximal coronary hyperemia with adenosine, and during increased myocardial work with dobutamine. Abnormal flow was defined as myocardial blood flow <75% of maximum perfusion during adenosine plus placebo (46 normal/17 abnormal segments dentified).
RESULTSCompared with placebo, tadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Similarly, in normal and abnormal segments, tadalafil versus placebo had no significant effect on resting myocardial blood flow or on adenosine-induced increases in myocardial blood flow. In normal segments, myocardial blood flow with dobutamine plus tadalafil was greater than that with dobutamine plus placebo (1.79±0.56 versus 1.56±0.37 ml/g per min, P<0.01), and in abnormal segments, there was a trend for tadalafil compared with placebo to increase myocardial blood flow during dobutamine infusion (1.46±0.44 versus 1.36±0.36 ml/g per min, P=0.7).
CONCLUSIONSTadalafil had no significant effect on global myocardial blood flow at rest, during adenosine infusion, or during dobutamine infusion. Compared with placebo, tadalafil significantly augmented myocardial blood flow during increased workload in normal regions, with a trend toward improving myocardial blood flow in poorly perfused regions.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16905960</pmid><doi>10.1097/00019501-200609000-00001</doi><tpages>7</tpages></addata></record> |
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| ispartof | Coronary artery disease, 2006-09, Vol.17 (6), p.493-499 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenosine - administration & dosage Aged Carbolines - pharmacology Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary Circulation - drug effects Coronary Circulation - physiology Cross-Over Studies Dobutamine - administration & dosage Double-Blind Method Humans Infusions, Intravenous Male Middle Aged Phosphodiesterase Inhibitors - pharmacology Radionuclide Imaging Tadalafil |
| title | Effects of tadalafil on myocardial blood flow in patients with coronary artery disease |
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