Cardiac neural crest
Neural crest cells (NCCs) contribute to many organs and tissues during embryonic development. Amongst these, the cardiovascular system represents a fascinating example. In this review, recent advances in our understanding of the developmental biology and molecular genetics regulating cardiac NCC mat...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2005-12, Vol.16 (6), p.704-715 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Stoller, Jason Z. Epstein, Jonathan A. |
| description | Neural crest cells (NCCs) contribute to many organs and tissues during embryonic development. Amongst these, the cardiovascular system represents a fascinating example. In this review, recent advances in our understanding of the developmental biology and molecular genetics regulating cardiac NCC maturation will be summarized. While the existence of a significant neural crest (NC) contribution to the developing heart has been appreciated for more than 20 years, only in the last few years have molecular pathways regulating this process been elucidated and the significant contribution of these mechanisms to the etiology of congenital heart disease in man become apparent. Emerging data suggest that ongoing studies will reveal complex inductive interactions between cardiac NC and a series of other cell types contributing to the developing cardiovascular system. |
| doi_str_mv | 10.1016/j.semcdb.2005.06.004 |
| format | Article |
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Emerging data suggest that ongoing studies will reveal complex inductive interactions between cardiac NC and a series of other cell types contributing to the developing cardiovascular system.</description><identifier>ISSN: 1084-9521</identifier><identifier>EISSN: 1096-3634</identifier><identifier>DOI: 10.1016/j.semcdb.2005.06.004</identifier><identifier>PMID: 16054405</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Aorta - cytology ; Aorta - embryology ; Biological Evolution ; Cardiac development ; Chick Embryo ; Congenital heart disease ; DiGeorge syndrome ; Heart - embryology ; Heart Defects, Congenital - genetics ; Humans ; Mice ; Mice, Transgenic ; Micronutrients - physiology ; Neural Crest - cytology ; Neural Crest - embryology ; Neural Crest - metabolism ; Notch ; Recombination, Genetic ; Semaphorin ; Signal Transduction ; Transforming growth factor</subject><ispartof>Seminars in cell & developmental biology, 2005-12, Vol.16 (6), p.704-715</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-9058f2d7aed5ca68f1d7ca4771327376469e7385b19f8d6e636ed75c1dee33a23</citedby><cites>FETCH-LOGICAL-c391t-9058f2d7aed5ca68f1d7ca4771327376469e7385b19f8d6e636ed75c1dee33a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.semcdb.2005.06.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16054405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoller, Jason Z.</creatorcontrib><creatorcontrib>Epstein, Jonathan A.</creatorcontrib><title>Cardiac neural crest</title><title>Seminars in cell & developmental biology</title><addtitle>Semin Cell Dev Biol</addtitle><description>Neural crest cells (NCCs) contribute to many organs and tissues during embryonic development. Amongst these, the cardiovascular system represents a fascinating example. In this review, recent advances in our understanding of the developmental biology and molecular genetics regulating cardiac NCC maturation will be summarized. While the existence of a significant neural crest (NC) contribution to the developing heart has been appreciated for more than 20 years, only in the last few years have molecular pathways regulating this process been elucidated and the significant contribution of these mechanisms to the etiology of congenital heart disease in man become apparent. Emerging data suggest that ongoing studies will reveal complex inductive interactions between cardiac NC and a series of other cell types contributing to the developing cardiovascular system.</description><subject>Animals</subject><subject>Aorta - cytology</subject><subject>Aorta - embryology</subject><subject>Biological Evolution</subject><subject>Cardiac development</subject><subject>Chick Embryo</subject><subject>Congenital heart disease</subject><subject>DiGeorge syndrome</subject><subject>Heart - embryology</subject><subject>Heart Defects, Congenital - genetics</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Micronutrients - physiology</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - embryology</subject><subject>Neural Crest - metabolism</subject><subject>Notch</subject><subject>Recombination, Genetic</subject><subject>Semaphorin</subject><subject>Signal Transduction</subject><subject>Transforming growth factor</subject><issn>1084-9521</issn><issn>1096-3634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LAzEQhYMotlZvHkU8edt1skkm2YsgxV9Q8KLnkCazsKXbrUlX8L83ZQve9DRz-N578DF2xaHkwPFuVSbqfFiWFYAqAUsAecSmHGosBAp5vP-NLGpV8Qk7S2kFmagrPGUTjqCkBDVll3MXQ-v8zYaG6NY3PlLanbOTxq0TXRzujH08Pb7PX4rF2_Pr_GFReFHzXVGDMk0VtKOgvEPT8KC9k1pzUWmhUWJNWhi15HVjAhIKpKCV54FICFeJGbsde7ex_xzysO3a5Gm9dhvqh2TR5BptxL9gBSgEGJ5BOYI-9ilFauw2tp2L35aD3WuzKztqs3ttFtBmKTl2fegflh2F39DBUwbuR4Cyjq-Wok2-pY2n0EbyOxv69u-FH9iGfR4</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Stoller, Jason Z.</creator><creator>Epstein, Jonathan A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20051201</creationdate><title>Cardiac neural crest</title><author>Stoller, Jason Z. ; Epstein, Jonathan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-9058f2d7aed5ca68f1d7ca4771327376469e7385b19f8d6e636ed75c1dee33a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Aorta - cytology</topic><topic>Aorta - embryology</topic><topic>Biological Evolution</topic><topic>Cardiac development</topic><topic>Chick Embryo</topic><topic>Congenital heart disease</topic><topic>DiGeorge syndrome</topic><topic>Heart - embryology</topic><topic>Heart Defects, Congenital - genetics</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Micronutrients - physiology</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - embryology</topic><topic>Neural Crest - metabolism</topic><topic>Notch</topic><topic>Recombination, Genetic</topic><topic>Semaphorin</topic><topic>Signal Transduction</topic><topic>Transforming growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoller, Jason Z.</creatorcontrib><creatorcontrib>Epstein, Jonathan A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in cell & developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoller, Jason Z.</au><au>Epstein, Jonathan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac neural crest</atitle><jtitle>Seminars in cell & developmental biology</jtitle><addtitle>Semin Cell Dev Biol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>16</volume><issue>6</issue><spage>704</spage><epage>715</epage><pages>704-715</pages><issn>1084-9521</issn><eissn>1096-3634</eissn><abstract>Neural crest cells (NCCs) contribute to many organs and tissues during embryonic development. 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| ispartof | Seminars in cell & developmental biology, 2005-12, Vol.16 (6), p.704-715 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Aorta - cytology Aorta - embryology Biological Evolution Cardiac development Chick Embryo Congenital heart disease DiGeorge syndrome Heart - embryology Heart Defects, Congenital - genetics Humans Mice Mice, Transgenic Micronutrients - physiology Neural Crest - cytology Neural Crest - embryology Neural Crest - metabolism Notch Recombination, Genetic Semaphorin Signal Transduction Transforming growth factor |
| title | Cardiac neural crest |
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