α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease

The distribution and tempo of neuronal loss in Parkinson's disease correlates poorly with the characteristic and more widely spread intracellular changes associated with the disease process (Lewy bodies and Lewy neurites). To determine early intracellular changes in regions where cell loss is m...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2005-11, Vol.128 (11), p.2654-2664
Hauptverfasser:	Halliday, Glenda M., Ophof, Anita, Broe, Melissa, Jensen, Poul H., Kettle, Emma, Fedorow, Heidi, Cartwright, Michael I., Griffiths, Francine M., Shepherd, Claire E., Double, Kay L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over alpha-Synuclein - metabolism ANOVA = analysis of variance Biological and medical sciences Brain Stem - pathology Cell Death Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression DMNX = dorsal motor nucleus of the vagus nerve Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans LC = locus coeruleus Lewy Bodies - pathology lipid Male Medical sciences Melanins - metabolism Microscopy, Electron Nervous system (semeiology, syndromes) Neurology neuromelanin Neurons - ultrastructure NM = neuromelanin Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease SN = substantia nigra Substantia Nigra - metabolism Substantia Nigra - ultrastructure α-synuclein
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