Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control

Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactin-dependent processes is not clearly understood. Here we generate...

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Veröffentlicht in:	Molecular biology of the cell 2005-11, Vol.16 (11), p.5127-5140
Hauptverfasser:	Siller, Karsten H, Serr, Madeline, Steward, Ruth, Hays, Tom S, Doe, Chris Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Brain - cytology Brain - embryology Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Cycle Cell Cycle Proteins - metabolism Centrosome - metabolism Drosophila Drosophila - genetics Drosophila Proteins - metabolism Dynactin Complex Dyneins - physiology Epistasis, Genetic In Vitro Techniques Kinetochores - metabolism Larva Microscopy, Video Microtubule-Associated Proteins - metabolism Microtubule-Associated Proteins - physiology Mitosis Models, Biological Spindle Apparatus - genetics Spindle Apparatus - physiology
Online-Zugang:	Volltext
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