Attenuating Effect of Artemin on Herpes-related Pain Responses in Mice Infected with Herpes Simplex
The influence of artemin (AR) on herpes-related pain responses was examined using mice infected with herpes simplex virus (HSV). BALB/c mice were inoculated with HSV (1Ã10 6 plaque-forming units) on the right hind paw, while the contralateral hind paw was without inoculation. The changes in nocicep...
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| Veröffentlicht in: | In vivo (Athens) 2006-07, Vol.20 (4), p.533-537 |
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| creator | Asano, Kazuhito Asahina, Shigeru Sakai, Misako Matsuda, Takako Ou, Kouei Maeda, Yu Hisamitsu, Tadashi |
| description | The influence of artemin (AR) on herpes-related pain responses was examined using mice infected with herpes simplex virus
(HSV). BALB/c mice were inoculated with HSV (1Ã10 6 plaque-forming units) on the right hind paw, while the contralateral hind paw was without inoculation. The changes in nociceptive
threshold were examined using an electric Von Fray meter. Intraperitoneal administration of AR prevented a decrease in nociceptive
threshold dose-dependently in HSV-inoculated mice, which was first observed at a dose of 1.0 mg/kg and peaked at doses higher
than 1.5 mg/kg. This antinociceptive effect of AR attained peaks at 120 min after administration and declined gradually to
non-treated levels by 270 min. Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected β-endorphin and
noradrenaline levels in the central nervous system of HSV-inoculated mice. However, AR caused a significant decrease of the
dynorphin levels in spinal cord. These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain
through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice. It is also suggested that AR
will be a good candidate as an antinociceptive drug for the treatment of acute herpetic pain in humans. |
| format | Article |
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(HSV). BALB/c mice were inoculated with HSV (1Ã10 6 plaque-forming units) on the right hind paw, while the contralateral hind paw was without inoculation. The changes in nociceptive
threshold were examined using an electric Von Fray meter. Intraperitoneal administration of AR prevented a decrease in nociceptive
threshold dose-dependently in HSV-inoculated mice, which was first observed at a dose of 1.0 mg/kg and peaked at doses higher
than 1.5 mg/kg. This antinociceptive effect of AR attained peaks at 120 min after administration and declined gradually to
non-treated levels by 270 min. Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected β-endorphin and
noradrenaline levels in the central nervous system of HSV-inoculated mice. However, AR caused a significant decrease of the
dynorphin levels in spinal cord. These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain
through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice. It is also suggested that AR
will be a good candidate as an antinociceptive drug for the treatment of acute herpetic pain in humans.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 16900785</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Analgesics - administration & dosage ; Analgesics - pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Herpes Simplex - complications ; Herpesviridae Infections - complications ; Herpesviridae Infections - virology ; Mice ; Mice, Inbred BALB C ; Pain - drug therapy ; Pain - pathology ; Pain - virology ; Pain Threshold - drug effects ; Simplexvirus - pathogenicity ; Specific Pathogen-Free Organisms ; Time Factors</subject><ispartof>In vivo (Athens), 2006-07, Vol.20 (4), p.533-537</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16900785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asano, Kazuhito</creatorcontrib><creatorcontrib>Asahina, Shigeru</creatorcontrib><creatorcontrib>Sakai, Misako</creatorcontrib><creatorcontrib>Matsuda, Takako</creatorcontrib><creatorcontrib>Ou, Kouei</creatorcontrib><creatorcontrib>Maeda, Yu</creatorcontrib><creatorcontrib>Hisamitsu, Tadashi</creatorcontrib><title>Attenuating Effect of Artemin on Herpes-related Pain Responses in Mice Infected with Herpes Simplex</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>The influence of artemin (AR) on herpes-related pain responses was examined using mice infected with herpes simplex virus
(HSV). BALB/c mice were inoculated with HSV (1Ã10 6 plaque-forming units) on the right hind paw, while the contralateral hind paw was without inoculation. The changes in nociceptive
threshold were examined using an electric Von Fray meter. Intraperitoneal administration of AR prevented a decrease in nociceptive
threshold dose-dependently in HSV-inoculated mice, which was first observed at a dose of 1.0 mg/kg and peaked at doses higher
than 1.5 mg/kg. This antinociceptive effect of AR attained peaks at 120 min after administration and declined gradually to
non-treated levels by 270 min. Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected β-endorphin and
noradrenaline levels in the central nervous system of HSV-inoculated mice. However, AR caused a significant decrease of the
dynorphin levels in spinal cord. These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain
through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice. It is also suggested that AR
will be a good candidate as an antinociceptive drug for the treatment of acute herpetic pain in humans.</description><subject>Analgesics - administration & dosage</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Herpes Simplex - complications</subject><subject>Herpesviridae Infections - complications</subject><subject>Herpesviridae Infections - virology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pain - drug therapy</subject><subject>Pain - pathology</subject><subject>Pain - virology</subject><subject>Pain Threshold - drug effects</subject><subject>Simplexvirus - pathogenicity</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Time Factors</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10EtLAzEQB_Agiq3VryA5iLeFPDfJsZRqCxXFB3gL2e1sN7IvN1mr396V1tMwM7__HOYETakyNFFSmFM0JUzqREv6PkEXIXwQkipC2Dma0NQQorSconweIzSDi77Z4WVRQB5xW-B5H6H2DW4bvIK-g5D0ULkIW_zkxvEzhK5tAgQ8Ng8-B7xu_qLjfu9jeczgF193FXxforPCVQGujnWG3u6Wr4tVsnm8Xy_mm6RkXMekICyjTFAiQeSgtWKUgnOCEZlmIAEKWZhcGaKckm6bscwISplLpcidIYbP0O3hbte3nwOEaGsfcqgq10A7BJtqxQXncoTXRzhkNWxt1_va9T_2_y0juDmA0u_Kve_BhtpV1ci59V-MWGEl5_wXAB5sAg</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Asano, Kazuhito</creator><creator>Asahina, Shigeru</creator><creator>Sakai, Misako</creator><creator>Matsuda, Takako</creator><creator>Ou, Kouei</creator><creator>Maeda, Yu</creator><creator>Hisamitsu, Tadashi</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Attenuating Effect of Artemin on Herpes-related Pain Responses in Mice Infected with Herpes Simplex</title><author>Asano, Kazuhito ; Asahina, Shigeru ; Sakai, Misako ; Matsuda, Takako ; Ou, Kouei ; Maeda, Yu ; Hisamitsu, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-f02b124105e4ce887211eaa42056be5eef5f9c7907a75adb2b94112a654ca9093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analgesics - administration & dosage</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Herpes Simplex - complications</topic><topic>Herpesviridae Infections - complications</topic><topic>Herpesviridae Infections - virology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Pain - drug therapy</topic><topic>Pain - pathology</topic><topic>Pain - virology</topic><topic>Pain Threshold - drug effects</topic><topic>Simplexvirus - pathogenicity</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asano, Kazuhito</creatorcontrib><creatorcontrib>Asahina, Shigeru</creatorcontrib><creatorcontrib>Sakai, Misako</creatorcontrib><creatorcontrib>Matsuda, Takako</creatorcontrib><creatorcontrib>Ou, Kouei</creatorcontrib><creatorcontrib>Maeda, Yu</creatorcontrib><creatorcontrib>Hisamitsu, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asano, Kazuhito</au><au>Asahina, Shigeru</au><au>Sakai, Misako</au><au>Matsuda, Takako</au><au>Ou, Kouei</au><au>Maeda, Yu</au><au>Hisamitsu, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuating Effect of Artemin on Herpes-related Pain Responses in Mice Infected with Herpes Simplex</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>20</volume><issue>4</issue><spage>533</spage><epage>537</epage><pages>533-537</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>The influence of artemin (AR) on herpes-related pain responses was examined using mice infected with herpes simplex virus
(HSV). BALB/c mice were inoculated with HSV (1Ã10 6 plaque-forming units) on the right hind paw, while the contralateral hind paw was without inoculation. The changes in nociceptive
threshold were examined using an electric Von Fray meter. Intraperitoneal administration of AR prevented a decrease in nociceptive
threshold dose-dependently in HSV-inoculated mice, which was first observed at a dose of 1.0 mg/kg and peaked at doses higher
than 1.5 mg/kg. This antinociceptive effect of AR attained peaks at 120 min after administration and declined gradually to
non-treated levels by 270 min. Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected β-endorphin and
noradrenaline levels in the central nervous system of HSV-inoculated mice. However, AR caused a significant decrease of the
dynorphin levels in spinal cord. These results strongly suggest that AR exerts antinociceptive effects on herpes-related pain
through changes of the dynorphin levels in the central nervous system of HSV-inoculated mice. It is also suggested that AR
will be a good candidate as an antinociceptive drug for the treatment of acute herpetic pain in humans.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>16900785</pmid><tpages>5</tpages></addata></record> |
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| subjects | Analgesics - administration & dosage Analgesics - pharmacology Animals Dose-Response Relationship, Drug Female Herpes Simplex - complications Herpesviridae Infections - complications Herpesviridae Infections - virology Mice Mice, Inbred BALB C Pain - drug therapy Pain - pathology Pain - virology Pain Threshold - drug effects Simplexvirus - pathogenicity Specific Pathogen-Free Organisms Time Factors |
| title | Attenuating Effect of Artemin on Herpes-related Pain Responses in Mice Infected with Herpes Simplex |
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