Enzymatic activation of voltage-gated potassium channels
Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials 1 . However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated b...
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| Veröffentlicht in: | Nature (London) 2006-08, Vol.442 (7103), p.696-699 |
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| creator | Ramu, Yajamana Xu, Yanping Lu, Zhe |
| description | Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials
1
. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K
+
(Kv) channels by a sphingomyelinase. |
| doi_str_mv | 10.1038/nature04880 |
| format | Article |
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1
. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K
+
(Kv) channels by a sphingomyelinase.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature04880</identifier><identifier>PMID: 16799569</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Cell membranes. Ionic channels. Membrane pores ; Cell structures and functions ; Cellular biology ; Enzymes ; Eukaryotes ; Fundamental and applied biological sciences. Psychology ; Histidine - genetics ; Histidine - metabolism ; Humanities and Social Sciences ; Hydrogen-Ion Concentration ; Ion Channel Gating - physiology ; Ions ; Kinetics ; letter ; Magnesium - pharmacology ; Membrane Potentials ; Molecular and cellular biology ; multidisciplinary ; Mutation - genetics ; Pharmacology ; Phosphoric Diester Hydrolases - metabolism ; Potassium Channels, Voltage-Gated - chemistry ; Potassium Channels, Voltage-Gated - genetics ; Potassium Channels, Voltage-Gated - metabolism ; Science ; Science (multidisciplinary) ; Shab Potassium Channels - genetics ; Shab Potassium Channels - metabolism ; Signal transduction ; Spider Venoms - enzymology</subject><ispartof>Nature (London), 2006-08, Vol.442 (7103), p.696-699</ispartof><rights>Springer Nature Limited 2006</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 10, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c652t-2046ac6d5d048fafc26842a91d98b91ec05145bc76aba8c821cfcdac4a24453</citedby><cites>FETCH-LOGICAL-c652t-2046ac6d5d048fafc26842a91d98b91ec05145bc76aba8c821cfcdac4a24453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nature04880$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nature04880$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18002340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16799569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramu, Yajamana</creatorcontrib><creatorcontrib>Xu, Yanping</creatorcontrib><creatorcontrib>Lu, Zhe</creatorcontrib><title>Enzymatic activation of voltage-gated potassium channels</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials
1
. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K
+
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Psychology</subject><subject>Histidine - genetics</subject><subject>Histidine - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Hydrogen-Ion Concentration</subject><subject>Ion Channel Gating - physiology</subject><subject>Ions</subject><subject>Kinetics</subject><subject>letter</subject><subject>Magnesium - pharmacology</subject><subject>Membrane Potentials</subject><subject>Molecular and cellular biology</subject><subject>multidisciplinary</subject><subject>Mutation - genetics</subject><subject>Pharmacology</subject><subject>Phosphoric Diester Hydrolases - metabolism</subject><subject>Potassium Channels, Voltage-Gated - chemistry</subject><subject>Potassium Channels, Voltage-Gated - genetics</subject><subject>Potassium Channels, Voltage-Gated - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Shab Potassium Channels - genetics</subject><subject>Shab Potassium Channels - metabolism</subject><subject>Signal transduction</subject><subject>Spider Venoms - enzymology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0vFr1DAUB_AgijunP_m7HIKCaGfSpGn643FMHQwFN_DH8O41rRltckvS4fbXL-MObicnkh8a2k-_eS88Ql4zesIoV58dpCkYKpSiT8iMiVoWQqr6KZlRWqqCKi6PyIsYryilFavFc3LEZN00lWxmRJ26u9sRksU5YLI3eefd3HfzGz8k6E3RQzLtfO0TxGincY6_wTkzxJfkWQdDNK-2z2Ny8eX0cvmtOP_x9Wy5OC9QVmUqSiokoGyrNhfYQYelVKKEhrWNWjXMYC5JVCusJaxAoSoZdtgCCiiFqPgxeb9JXQd_PZmY9GgjmmEAZ_wUde6T81rw_0IuWSUELzN8-xe88lNwuQWda614rk5kVGxQD4PR1nU-BcDeOBNg8M50Nr9eMJUjVSXFLnTP49pe68fo5ADKqzWjxYOpH_Z-yCaZP6mHKUZ9dvFz3378t11c_lp-P6gx-BiD6fQ62BHCrWZUPwyVfjRUWb_ZXtm0Gk27s9spyuDdFkBEGLoADm3cOZUHkYuHoE8bF_Mn15uwu_tD594DP0Lf_A</recordid><startdate>20060810</startdate><enddate>20060810</enddate><creator>Ramu, Yajamana</creator><creator>Xu, Yanping</creator><creator>Lu, Zhe</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ATWCN</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>20060810</creationdate><title>Enzymatic activation of voltage-gated potassium channels</title><author>Ramu, Yajamana ; Xu, Yanping ; Lu, Zhe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c652t-2046ac6d5d048fafc26842a91d98b91ec05145bc76aba8c821cfcdac4a24453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell membranes. 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramu, Yajamana</au><au>Xu, Yanping</au><au>Lu, Zhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic activation of voltage-gated potassium channels</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2006-08-10</date><risdate>2006</risdate><volume>442</volume><issue>7103</issue><spage>696</spage><epage>699</epage><pages>696-699</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials
1
. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K
+
(Kv) channels by a sphingomyelinase.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16799569</pmid><doi>10.1038/nature04880</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nature (London), 2006-08, Vol.442 (7103), p.696-699 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature |
| subjects | Animals Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cellular biology Enzymes Eukaryotes Fundamental and applied biological sciences. Psychology Histidine - genetics Histidine - metabolism Humanities and Social Sciences Hydrogen-Ion Concentration Ion Channel Gating - physiology Ions Kinetics letter Magnesium - pharmacology Membrane Potentials Molecular and cellular biology multidisciplinary Mutation - genetics Pharmacology Phosphoric Diester Hydrolases - metabolism Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Science Science (multidisciplinary) Shab Potassium Channels - genetics Shab Potassium Channels - metabolism Signal transduction Spider Venoms - enzymology |
| title | Enzymatic activation of voltage-gated potassium channels |
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