Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE3Leiden mice

BACKGROUND: The prevalence of dyslipidemia and obesity resulting from excess energy intake and physical inactivity is increasing. The liver plays a pivotal role in systemic lipid homeostasis. Effective, natural dietary interventions that lower plasma lipids and promote liver health are needed. OBJEC...

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Veröffentlicht in:	The American journal of clinical nutrition 2006-08, Vol.84 (2), p.312-321
Hauptverfasser:	Duivenvoorden, Ilse, Voshol, Peter J, Rensen, Patrick CN, Duyvenvoorde, Wim van, Romijn, Johannes A, Emeis, Jef J, Havekes, Louis M, Nieuwenhuizen, Willem F
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine transaminase amyloid A animal models Animals Apolipoprotein E3 Apolipoproteins E - genetics Biological and medical sciences biomarkers blood lipids Cholesterol Cholesterol - blood Cholesterol, Dietary - pharmacokinetics cholesteryl esters color dietary fat disease prevention Dose-Response Relationship, Drug energy intake Fatty acids Fatty Acids, Nonesterified - pharmacokinetics fatty liver Fatty Liver - prevention & control Feces - chemistry Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gene Expression homeostasis inflammation Intestinal Absorption - drug effects lipid metabolism Lipid Metabolism - drug effects Lipid Metabolism - physiology Lipids lipolysis Lipolysis - drug effects Lipolysis - physiology Lipoproteins, VLDL - chemistry Lipoproteins, VLDL - metabolism Liver Liver - drug effects Liver - enzymology Liver - metabolism low density lipoprotein messenger RNA Mice Mice, Transgenic physical activity Plasma Random Allocation RNA - metabolism Rodents sphingolipids Sphingolipids - administration & dosage Sphingolipids - pharmacology tissue weight triacylglycerols Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems very low density lipoprotein
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