Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease

The expansion of a polymorphic CAG repeat in the HD gene encoding huntingtin has been identified as the major cause of Huntington's disease (HD) and determines 42-73% of the variance in the age-at-onset of the disease. Polymorphisms in huntingtin interacting or associated genes are thought to m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human genetics 2006-09, Vol.120 (2), p.285-292
Hauptverfasser:	METZGER, Silke, BAUER, Peter, SEPPI, Klaus, MELEGH, Bela, HAVASI, Viktoria, BALIKO, Laszlo, WIECZOREK, Stefan, ZAREMBA, Jacek, HOFFMAN-ZACHARSKA, Dorota, SULEK, Anna, NAZLI BASAK, A, SOYDAN, Esra, TOMIUK, Jürgen, ZIDOVSKA, Jana, KEBRDLOVA, Vera, PANDOLFO, Massimo, RIBÏ, Pascale, KADASI, Ludovit, KVASNICOVA, Marta, WEBER, Bernhard H. F, KREUZ, Friedmar, DOSE, Matthias, STUHRMANN, Manfred, LACCONE, Franco, RIESS, Olaf, DIDONATO, Stefano, GELLERA, Cinzia, MARIOTTI, Caterina, LANGE, Herwig W, WEIRICH-SCHWAIGER, Helga, WENNING, Gregor K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases Adaptor Proteins, Signal Transducing Adolescent Adult Adult and adolescent clinical studies Age Age of Onset Aged Aged, 80 and over Biological and medical sciences Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Child Child, Preschool Classical genetics, quantitative genetics, hybrids Collaboration Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Genes Genetics Genetics of eukaryotes. Biological and molecular evolution Genomes GluK2 Kainate Receptor Human Humans Huntingtin Protein Huntington Disease - epidemiology Huntington Disease - genetics Huntington Disease - metabolism Huntingtons disease Medical sciences Middle Aged Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Nuclear Proteins - metabolism Organic mental disorders. Neuropsychology Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Kainic Acid - genetics TATA-Box Binding Protein - genetics TATA-Box Binding Protein - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!