A Validated Quantitative Assay to Detect Occult Micrometastases by Reverse Transcriptase-Polymerase Chain Reaction of Guanylyl Cyclase C in Patients with Colorectal Cancer

Purpose: Guanylyl cyclase C (GCC), a receptor for bacterial diarrheagenic enterotoxins, may be a prognostic and predictive marker to detect occult micrometastases in patients undergoing staging for colorectal cancer. However, quantification of GCC expression in tissues by the quantitative reverse tr...

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Veröffentlicht in:	Clinical cancer research 2006-08, Vol.12 (15), p.4545-4552
Hauptverfasser:	Schulz, Stephanie, Hyslop, Terry, Haaf, Janis, Bonaccorso, Christine, Nielsen, Karl, Witek, Matthew E, Birbe, Ruth, Palazzo, Juan, Weinberg, David, Waldman, Scott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Calibration colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Female Gene Expression Profiling Guanylate Cyclase - genetics guanylyl cyclase C Humans Lymphatic Metastasis - diagnosis Lymphatic Metastasis - genetics Male Middle Aged molecular marker occult micrometastases real-time reverse transcription-PCR Receptors, Enterotoxin Receptors, Guanylate Cyclase-Coupled Receptors, Peptide - genetics Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Complementary - genetics RNA, Messenger - genetics Sensitivity and Specificity
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